Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals

Autor: Lingling Ding, Tom Houben, Yvonne Oligschlaeger, Albert V. Bitorina, Bart J. Verwer, Maarten E. Tushuizen, Ronit Shiri-Sverdlov

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

ObjectiveType 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance. Previous studies in patients demonstrated that plasma levels of cathepsin D (CTSD), which is optimally active in the acidic environment of lysosomes, corre

Externí odkaz: https://doaj.org/article/76ee5e60d2944982927fd70735b568d1

Drug withdrawal in patients with autoimmune hepatitis in long-term histological remission: A prospective observational study

Autor: Romée J. A. L. M. Snijders, Elisabeth Bloemena, Gerd Bouma, Floris F. van den Brand, Ynto S. de Boer, Carin M.J. van Nieuwkerk, Sjoerd D. Kuiken, Bart J. Verwer, Joost P.H. Drenth

Publikováno v: van den Brand, F F, Snijders, R J A L M, de Boer, Y S, Verwer, B J, van Nieuwkerk, C M J, Bloemena, E, Kuiken, S D, Drenth, J P H & Bouma, G 2021, ' Drug withdrawal in patients with autoimmune hepatitis in long-term histological remission: A prospective observational study ', European Journal of Internal Medicine, vol. 90, pp. 30-36 . https://doi.org/10.1016/j.ejim.2021.03.024
European Journal of Internal Medicine, 90, 30-36
European Journal of Internal Medicine, 90, 30-36. Elsevier
van den Brand, F F, Snijders, R J A L M, de Boer, Y S, Verwer, B J, van Nieuwkerk, C M J, Bloemena, E, Kuiken, S D, Drenth, J P H & Bouma, G 2021, ' Drug withdrawal in patients with autoimmune hepatitis in long-term histological remission : A prospective observational study ', European Journal of Internal Medicine, vol. 90, pp. 30-36 . https://doi.org/10.1016/j.ejim.2021.03.024
European journal of internal medicine, 90, 30-36. Elsevier
European Journal of Internal Medicine, 90, pp. 30-36

Background Recommendations for drug withdrawal in patients with autoimmune hepatitis (AIH) in longstanding remission are conflicting and rely on retrospective data. We prospectively investigated the predictive value of histological normalisation for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61db903bcfd94aaa25fbecc6920ea001
https://research.vumc.nl/en/publications/2894391b-d095-4877-ace1-5a7c97585858

Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands

Autor: Frank ter Borg, Floris F. van den Brand, Adriaan C.I.T.L. Tan, Bart J. Verwer, Gerd Bouma, Nanne K. H. de Boer, Akin Inderson, Elisabeth Bloemena, J.M. Vrolijk, Ynto S. de Boer, Christine M. Bakker, Sven Van Den Hazel, Martijn J. ter Borg, Chris J. J. Mulder, Joost P.H. Drenth, Maarten E. Tushuizen, Carin M.J. van Nieuwkerk

Publikováno v: Alimentary Pharmacology & Therapeutics
Alimentary pharmacology & therapeutics, 48(7), 761-767
Alimentary Pharmacology & Therapeutics, 48, 761-767
van den Brand, F F, van Nieuwkerk, C M J, Verwer, B J, de Boer, Y S, de Boer, N K H, Mulder, C J J, Bloemena, E, Bakker, C M, Vrolijk, J M, Drenth, J P H, Tan, A C I T L, Ter Borg, F, Ter Borg, M J, van den Hazel, S J, Inderson, A, Tushuizen, M E & Bouma, G 2018, ' Biochemical efficacy of tioguanine in autoimmune hepatitis : a retrospective review of practice in the Netherlands ', Alimentary pharmacology & therapeutics, vol. 48, no. 7, pp. 761-767 . https://doi.org/10.1111/apt.14939
Alimentary Pharmacology and Therapeutics, 48(7), 761-767
Alimentary Pharmacology & Therapeutics, 48, 7, pp. 761-767

Contains fulltext : 195713.pdf (Publisher’s version ) (Open Access) BACKGROUND: Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid-sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e0a5ea9102d6d2aacd1e57490e9679
https://hdl.handle.net/1887/75673

Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission

Autor: Nicole M F, van Gerven, Bart J, Verwer, Birgit I, Witte, Bart, van Hoek, Minneke J, Coenraad, Karel J, van Erpecum, Ulrich, Beuers, Henk R, van Buuren, Rob A, de Man, Joost P H, Drenth, Jannie W, den Ouden, Robert C, Verdonk, Ger H, Koek, Johannes T, Brouwer, Maureen M J, Guichelaar, Chris J J, Mulder, Karin M J, van Nieuwkerk, Gerd, Bouma, M A M T, Verhagen

Publikováno v: van Gerven, N M F, Verwer, B J, Witte, B I, van Hoek, B, Coenraad, M J, van Erpecum, K J, Beuers, U, van Buuren, H R, de Man, R A, Drenth, J P H, den Ouden, J W, Verdonk, R C, Koek, G H, Brouwer, J T, Guichelaar, M M J, Mulder, C J J, van Nieuwkerk, C M J & Bouma, G 2013, ' Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission ', Journal of Hepatology, vol. 58, no. 1, pp. 141-147 . https://doi.org/10.1016/j.jhep.2012.09.009
Journal of Hepatology, 58, 141-7
Journal of Hepatology, 58(1), 141-147. Elsevier Science
Journal of Hepatology, 58(1), 141-147
Journal of Hepatology, 58(1), 141-147. Elsevier
Journal of Hepatology, 58(1), 141-147. ELSEVIER SCIENCE BV
Journal of hepatology, 58(1), 141-147. Elsevier
Journal of Hepatology, 58, 1, pp. 141-7

Background & Aims: Current treatment strategies in autoimmune hepatitis (AIH) include long-term treatment with corticosteroids and/or azathioprine. Here we determined the risk of relapse after drug withdrawal in patients in long-term remission and fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c908ca065c308833e67dd137bd1504
https://hdl.handle.net/1887/96970

Risk assessment of posthepatectomy liver failure using hepatobiliary scintigraphy and CT volumetry

Autor: Roelof J. Bennink, Bart J Verwer, Krijn P. van Lienden, Dirk J. Gouma, Sander Dinant, Arlène K. van Vliet, Thomas M. van Gulik, Wilmar de Graaf

Publikováno v: Journal of nuclear medicine, 48(5), 685-692. Society of Nuclear Medicine Inc.

A major part of morbidity and mortality after liver resections is caused by inadequate remnant liver function leading to liver failure. It is therefore important to develop accurate diagnostic tools that can predict the risk of liver resection-relate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cf2a072a2f1b957dc3e75907607296
https://pubmed.ncbi.nlm.nih.gov/17475954