Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Bart J L, Eggen"'
Autor:
Angélica María Sabogal-Guáqueta, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Asmaa Oun, Jasmijn Hunneman, Tingting Chen, Jari Koistinaho, Sarka Lehtonen, Arjan Kortholt, Justina C. Wolters, Barbara M. Bakker, Bart J. L. Eggen, Erik Boddeke, Amalia Dolga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) to glycolysis or alterations in other metabolic pathways. However
Externí odkaz:
https://doaj.org/article/84b22256347c40f5852d44e2ee2ceacc
Autor:
Wendy Oost, Allard J. Huitema, Kim Kats, Ben N. G. Giepmans, Susanne M. Kooistra, Bart J. L. Eggen, Wia Baron
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which increases axo
Externí odkaz:
https://doaj.org/article/95bce4d9d47941768755f87d87b64b26
Autor:
Kitty Reemst, Laura Kracht, Janssen M. Kotah, Reza Rahimian, Astrid A. S. van Irsen, Gonzalo Congrains Sotomayor, Laura N. Verboon, Nieske Brouwer, Sophie Simard, Gustavo Turecki, Naguib Mechawar, Susanne M. Kooistra, Bart J. L. Eggen, Aniko Korosi
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, th
Externí odkaz:
https://doaj.org/article/db2a1285bcce4eab802b36ede32826ef
Autor:
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative s
Externí odkaz:
https://doaj.org/article/3973528986d64d68a5883cd398983c49
Autor:
Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans-Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point towards
Externí odkaz:
https://doaj.org/article/e6a6235939ee4b9089024f9f8ef305b6
Autor:
Malte Borggrewe, Susanne M. Kooistra, Evelyn M. Wesseling, Fenja L. Gierschek, Maaike L. Brummer, Elizabeth C. Nowak, Tiago Medeiros-Furquim, Tegan A. Otto, Sam W. Lee, Randolph J. Noelle, Bart J. L. Eggen, Jon D. Laman
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is a negative checkpoint regulator (NCR) that is involved in T-cell quiescence, inhibition of T-cell activation, and in myeloid cells regulates cytokine producti
Externí odkaz:
https://doaj.org/article/4bdc13e15de849f6a6de101e17552924
Autor:
Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman, Bart J. L. Eggen
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively. Exposing monocytes to moderate-to-high
Externí odkaz:
https://doaj.org/article/15679170a3e845cf9c8bc18398d65bc6
Autor:
Inge L. Werkman, Marissa L. Dubbelaar, Pieter van der Vlies, Jelkje J. de Boer-Bergsma, Bart J. L. Eggen, Wia Baron
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background Multiple sclerosis (MS) is an inflammation-mediated demyelinating disease of the central nervous system that eventually results in secondary axonal degeneration due to remyelination failure. Successful remyelination is orchestrate
Externí odkaz:
https://doaj.org/article/093370fa1b464b87adfed57d7737a7d8
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Multiple sclerosis (MS) is a complex auto-immune disorder of the central nervous system (CNS) that involves a range of CNS and immune cells. MS is characterized by chronic neuroinflammation, demyelination, and neuronal loss, but the molecular causes
Externí odkaz:
https://doaj.org/article/30cc4a7da8194826ab11b41930df2a3d
Autor:
Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L. Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M. Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P. Biber, Susanne M. Kooistra, Erik W. G. M. Boddeke, Bart J. L. Eggen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation in Alzheimer
Externí odkaz:
https://doaj.org/article/cf41d44a7139428b829cb962c615f345