Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Bart Geverts"'
Autor:
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Externí odkaz:
https://doaj.org/article/8ae0ddc4ec8841d3a8a8b7435095a252
Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP.
Autor:
Femke L Groeneweg, Martin E van Royen, Susanne Fenz, Veer I P Keizer, Bart Geverts, Jurrien Prins, E Ron de Kloet, Adriaan B Houtsmuller, Thomas S Schmidt, Marcel J M Schaaf
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90532 (2014)
Recent advances in live cell imaging have provided a wealth of data on the dynamics of transcription factors. However, a consistent quantitative description of these dynamics, explaining how transcription factors find their target sequences in the va
Externí odkaz:
https://doaj.org/article/d47c3fc061a64d269c690076030ab728
Autor:
W Martijn ter Haar, Magda A Meester-Smoor, Karel H M van Wely, Claudia C M M Schot, Marjolein J F W Janssen, Bart Geverts, Jacqueline Bonten, Gerard C Grosveld, Adriaan B Houtsmuller, Ellen C Zwarthoff
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46085 (2012)
The leukemia-associated fusion protein MN1-TEL combines the transcription-activating domains of MN1 with the DNA-binding domain of the transcriptional repressor TEL. Quantitative photobleaching experiments revealed that ∼20% of GFP-tagged MN1 and T
Externí odkaz:
https://doaj.org/article/d0f348eb9bb8484dbff8f98ebdb66193
Autor:
Isabel Mayayo-Peralta, Sebastian Gregoricchio, Karianne Schuurman, Selçuk Yavuz, Anniek Zaalberg, Aleksandar Kojic, Nina Abbott, Bart Geverts, Suzanne Beerthuijzen, Joseph Siefert, Tesa M Severson, Martijn van Baalen, Liesbeth Hoekman, Cor Lieftink, Maarten Altelaar, Roderick L Beijersbergen, Adriaan B Houtsmuller, Stefan Prekovic, Wilbert Zwart
Publikováno v:
Nucleic Acids Research.
How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains only partly understood. Upon activation, SHRs bind the genome and recruit their co-regulators, crucial to induce gene expression. However, it remains unknown which comp
Autor:
Christine Helsen, Frank Claessens, Steven Joniau, Adriaan B. Houtsmuller, Lien Spans, Elien Smeets, Thomas Van den Broeck, Kam Y.J. Zhang, Diana Melchers, Rene Houtman, Bart Geverts, Arnout R.D. Voet, Martin E. van Royen, Stefan Prekovic
Table S1: Docking scores for the ligands and the AR mutants. Table S2: FRAP simulation data. Figure S1: Luciferase reporter assay for AR negative prostate cancer cell line (PC3 cells). We used 100 ng of reporter construct; and 10 ng of androgen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f20dddd2da4f62fbaf9e0b378c4a78b
https://doi.org/10.1158/1535-7163.22508553.v1
https://doi.org/10.1158/1535-7163.22508553.v1
Autor:
Christine Helsen, Frank Claessens, Steven Joniau, Adriaan B. Houtsmuller, Lien Spans, Elien Smeets, Thomas Van den Broeck, Kam Y.J. Zhang, Diana Melchers, Rene Houtman, Bart Geverts, Arnout R.D. Voet, Martin E. van Royen, Stefan Prekovic
Protocol of the cell viability assay performed on LAPC4 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dc3a0318a1da46cd5955f837a773da
https://doi.org/10.1158/1535-7163.22508550
https://doi.org/10.1158/1535-7163.22508550
Autor:
Joachim Boers, Frank Sleutels, Enrique Vidal, Rainer Renkawitz, Frank Grosveld, Ruben Boers, Niels Galjart, Mirjam C G N van den Hout, Silvia C Hernandez, Wiggert A. van Cappellen, Sarra Merzouk, Adriaan B Houtsmuller, Gregoire Stik, Marek Bartkuhn, Michael van der Reijden, Joost Gribnau, Thomas Graf, Zeliha Ozgur, Sreya Basu, Ralph Stadhouders, Widia Soochit, Bart Geverts, Wilfred F. J. van IJcken
Publikováno v:
Dev Cell
Nature Cell Biology, 23(8), 881-893. Nature Publishing Group
Nature Cell Biology, 23(8), 881-893. Nature Publishing Group
The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic sites. Here, we replaced endogenous CTCF in mouse embryonic stem cells with green-fluorescen
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Autor:
Fatma Özgün, Martin E. van Royen, Adriaan B Houtsmuller, Tsion E Abraham, Nathan A. Lack, Bart Geverts, Zeynep Kaya, Tunç Morova
Publikováno v:
Journal of Cell Science, 134(14):jcs258332. Company of Biologists Ltd
Androgen receptor (AR) splice variants are proposed to be a potential driver of lethal castration-resistant prostate cancer. AR splice variant 7 (ARv7) is the most commonly observed isoform and strongly correlates with resistance to second-generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d538a977b3d5a4df03aec74f1922b9
https://pure.eur.nl/en/publications/69dc424f-d8cf-4a7c-a2c6-396aa466a620
https://pure.eur.nl/en/publications/69dc424f-d8cf-4a7c-a2c6-396aa466a620
Autor:
René Bernards, Anja Raams, Jurgen A. Marteijn, Jesper Q. Svejstrup, Di Zhou, Arnab Ray Chaudhuri, Chirantani Mukherjee, Marvin van Toorn, Melanie van der Woude, Barbara Steurer, Arjan F. Theil, Wim Vermeulen, Joyce H.G. Lebbink, Kathiresan Selvam, Simona Cugusi, Adriaan B. Houtsmuller, Bart Geverts, Shisheng Li, Marit E. Geijer, Karel Bezstarosti, Bastiaan Evers, Hannes Lans, Jeroen Demmers, Roel C. Janssens, John J. Wyrick, Wenzhi Gong, Richard Mitter, Dalton A Plummer
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA Polymerase II (Pol II), causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counterac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cae2bdda9091fcb8bbddab66b9eb692
https://doi.org/10.1101/2021.05.11.443558
https://doi.org/10.1101/2021.05.11.443558