Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Bart Ferwerda"'
Autor:
Philip HC Kremer, Bart Ferwerda, Hester J Bootsma, Nienke Y Rots, Alienke J Wijmenga-Monsuur, Elisabeth AM Sanders, Krzysztof Trzciński, Anne L Wyllie, Paul Turner, Arie van der Ende, Matthijs C Brouwer, Stephen D Bentley, Diederik van de Beek, John A Lees
Publikováno v:
eLife, Vol 11 (2022)
The characteristics of pneumococcal carriage vary between infants and adults. Host immune factors have been shown to contribute to these age-specific differences, but the role of pathogen sequence variation is currently less well-known. Identificatio
Externí odkaz:
https://doaj.org/article/9ec714079bf14fde998e4bff0c1b2d34
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genetic differences between individuals underlie susceptibility to many diseases. Genome-wide association studies (GWAS) have discovered many susceptibility genes but were often limited to cohorts of predominantly European ancestry. Genetic diversity
Externí odkaz:
https://doaj.org/article/4fe345b38e72449d9256481a788e6a16
Autor:
John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi
Externí odkaz:
https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3
Autor:
Philip H. C. Kremer, John A. Lees, Bart Ferwerda, Arie van de Ende, Matthijs C. Brouwer, Stephen D. Bentley, Diederik van de Beek
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Neisseria meningitidis causes sepsis and meningitis in humans. It has been suggested that pathogen genetic variation determines variance in disease severity. Here we report results of a genome-wide association study of 486 N. meningitidis genomes fro
Externí odkaz:
https://doaj.org/article/cc2bc4d694084b1b9e3dd1bda447ea9c
Autor:
Bart Ferwerda, Mylène M. Maury, Mathijs C. Brouwer, Lukas Hafner, Arie van der Ende, Stephen Bentley, Marc Lecuit, Diederik van de Beek
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Listeria monocytogenes is a Gram-positive bacterium that can be found in a broad range of environments, including soil, food, animals, and humans. L. monocytogenes can cause a foodborne disease manifesting as sepsis and meningo-encephalitis. To evalu
Externí odkaz:
https://doaj.org/article/3553d8c2557d4eea9d86322923e0e3b0
Autor:
Bart Ferwerda, Mercedes Valls Serón, Aldo Jongejan, Aeilko H. Zwinderman, Madelijn Geldhoff, Arie van der Ende, Frank Baas, Matthijs C. Brouwer, Diederik van de Beek
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 77-84 (2016)
Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Early recognition of the pathogen and subsequent innate immune response play a vital role in disease susceptibility and outcome. Genetic variations in innate immune g
Externí odkaz:
https://doaj.org/article/69ba02c7417646ad8ff80ebf9263ed5e
Autor:
Anne L. Wyllie, Yvonne Pannekoek, Sandra Bovenkerk, Jody van Engelsdorp Gastelaars, Bart Ferwerda, Diederik van de Beek, Elisabeth A. M. Sanders, Krzysztof Trzciński, Arie van der Ende
Publikováno v:
Open Biology, Vol 7, Iss 9 (2017)
The vast majority of streptococci colonizing the human upper respiratory tract are commensals, only sporadically implicated in disease. Of these, the most pathogenic is Mitis group member, Streptococcus pneumoniae. Phenotypic and genetic similarities
Externí odkaz:
https://doaj.org/article/88366f97d27941058845e122bdfd2c1c
Autor:
E. Soemirien Kasanmoentalib, Mercedes Valls Seron, Bart Ferwerda, Michael W. Tanck, Aeilko H. Zwinderman, Frank Baas, Arie van der Ende, William J. Schwaeble, Matthijs C. Brouwer, Diederik van de Beek
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/ce94495d788a44b8a178774fd3f47b23
Autor:
Montserrat Hervella, Theo S Plantinga, Santos Alonso, Bart Ferwerda, Neskuts Izagirre, Lara Fontecha, Rosa Fregel, Jos W M van der Meer, Concepcion de-la-Rúa, Mihai G Netea
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37022 (2012)
Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the "C" allele at CASP12 rs497116 has been associated with an increased risk of sepsis. Instead, the derived "T" allele encodes for an inactive caspase-12. Interestingly, Eurasian
Externí odkaz:
https://doaj.org/article/5a5459e25e64439f9b32a20f76276208
Autor:
Clara C Elbers, Yiran Guo, Vinicius Tragante, Erik P A van Iperen, Matthew B Lanktree, Berta Almoguera Castillo, Fang Chen, Lisa R Yanek, Mary K Wojczynski, Yun R Li, Bart Ferwerda, Christie M Ballantyne, Sarah G Buxbaum, Yii-Der Ida Chen, Wei-Min Chen, L Adrienne Cupples, Mary Cushman, Yanan Duan, David Duggan, Michele K Evans, Jyotika K Fernandes, Myriam Fornage, Melissa Garcia, W Timothy Garvey, Nicole Glazer, Felicia Gomez, Tamara B Harris, Indrani Halder, Virginia J Howard, Margaux F Keller, M Ilyas Kamboh, Charles Kooperberg, Stephen B Kritchevsky, Andrea LaCroix, Kiang Liu, Yongmei Liu, Kiran Musunuru, Anne B Newman, N Charlotte Onland-Moret, Jose Ordovas, Inga Peter, Wendy Post, Susan Redline, Steven E Reis, Richa Saxena, Pamela J Schreiner, Kelly A Volcik, Xingbin Wang, Salim Yusuf, Alan B Zonderland, Sonia S Anand, Diane M Becker, Bruce Psaty, Daniel J Rader, Alex P Reiner, Stephen S Rich, Jerome I Rotter, Michèle M Sale, Michael Y Tsai, Ingrid B Borecki, Robert A Hegele, Sekar Kathiresan, Michael A Nalls, Herman A Taylor, Hakon Hakonarson, Suthesh Sivapalaratnam, Folkert W Asselbergs, Fotios Drenos, James G Wilson, Brendan J Keating
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50198 (2012)
Meta-analyses of European populations has successfully identified genetic variants in over 100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited. To address this, we performed dense genotyping of ∼2,000 candi
Externí odkaz:
https://doaj.org/article/61a34aa47fe44caabf48c32acc494970