Pneumococcal genetic variability in age-dependent bacterial carriage

Autor: Philip HC Kremer, Bart Ferwerda, Hester J Bootsma, Nienke Y Rots, Alienke J Wijmenga-Monsuur, Elisabeth AM Sanders, Krzysztof Trzciński, Anne L Wyllie, Paul Turner, Arie van der Ende, Matthijs C Brouwer, Stephen D Bentley, Diederik van de Beek, John A Lees

Publikováno v: eLife, Vol 11 (2022)

The characteristics of pneumococcal carriage vary between infants and adults. Host immune factors have been shown to contribute to these age-specific differences, but the role of pathogen sequence variation is currently less well-known. Identificatio

Externí odkaz: https://doaj.org/article/9ec714079bf14fde998e4bff0c1b2d34

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Autor: John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi

Externí odkaz: https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3

Residual Variation Intolerance Score Detects Loci Under Selection in Neuroinvasive Listeria monocytogenes

Autor: Bart Ferwerda, Mylène M. Maury, Mathijs C. Brouwer, Lukas Hafner, Arie van der Ende, Stephen Bentley, Marc Lecuit, Diederik van de Beek

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Listeria monocytogenes is a Gram-positive bacterium that can be found in a broad range of environments, including soil, food, animals, and humans. L. monocytogenes can cause a foodborne disease manifesting as sepsis and meningo-encephalitis. To evalu

Externí odkaz: https://doaj.org/article/3553d8c2557d4eea9d86322923e0e3b0

Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome

Autor: Bart Ferwerda, Mercedes Valls Serón, Aldo Jongejan, Aeilko H. Zwinderman, Madelijn Geldhoff, Arie van der Ende, Frank Baas, Matthijs C. Brouwer, Diederik van de Beek

Publikováno v: EBioMedicine, Vol 10, Iss C, Pp 77-84 (2016)

Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Early recognition of the pathogen and subsequent innate immune response play a vital role in disease susceptibility and outcome. Genetic variations in innate immune g

Externí odkaz: https://doaj.org/article/69ba02c7417646ad8ff80ebf9263ed5e

Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer

Autor: Vivianne C. G. Tjan-Heijnen, Paul Hamberg, Vahram Hovsepjan, Aeilko H. Zwinderman, Mariette Labots, Frits I. Mulder, Laurens V. Beerepoot, Harry R. Büller, Albert J. ten Tije, Thijs F. van Haaps, Roos J van Geffen, Martijn P. Lolkema, Maartje Los, Hanneke W. M. van Laarhoven, Neeltje Steeghs, Bart Ferwerda, Noori A.M. Guman, Filip de Vos, Annelie Vulink, Pieter Willem Kamphuisen, Nick van Es, Geert A. Cirkel

Publikováno v: Journal of thrombosis and haemostasis, 19(12), 2974-2983. Wiley-Blackwell
Guman, N A M, van Geffen, R J, Mulder, F I, van Haaps, T F, Hovsepjan, V, Labots, M, Cirkel, G A, Y. F. L. de Vos, F, ten Tije, A J, Beerepoot, L V, Tjan-Heijnen, V C G, van Laarhoven, H W M, Hamberg, P, Vulink, A J E, Los, M, Zwinderman, A H, Ferwerda, B, Lolkema, M P J K, Steeghs, N, Büller, H R, Kamphuisen, P W & van Es, N 2021, ' Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer ', Journal of Thrombosis and Haemostasis, vol. 19, no. 12, pp. 2974-2983 . https://doi.org/10.1111/jth.15503
Journal of Thrombosis and Haemostasis, 19(12), 2974-2983. Wiley-Blackwell Publishing Ltd
Journal of Thrombosis and Haemostasis, 19(12), 2974-2983. Wiley
Journal of Thrombosis and Haemostasis, 19(12), 2974-2983. Wiley-Blackwell

Background: The Khorana score is a validated tool to identify cancer patients at higher risk of venous thromboembolism (VTE). Objective: We compared its predictive performance to that of the clinical PROTECHT and the polygenic 5-SNP scores in patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023500bbc942d7e6cdeee1e0b95d8151
https://pure.amc.nl/en/publications/evaluation-of-the-khorana-protecht-and-5snp-scores-for-prediction-of-venous-thromboembolism-in-patients-with-cancer(a3d7bd2d-5400-4ed2-b6d5-98bb01c97b86).html