SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis

Autor: Bianca Hemmeryckx, Elizabeth A. V. Jones, Wouter Verhesen, Rick van Leeuwen, Jurgen W. G. E. van Teeffelen, Anna-Pia Papageorgiou, Marieke Rienks, Daniel M. Johnson, Stephane Heymans, Bart Eskens, Paolo Carai

Publikováno v: Matrix Biology, 74, 21-34. Elsevier Science
Rienks, M, Carai, P, van Teeffelen, J, Eskens, B, Verhesen, W, Hemmeryckx, B, Johnson, D M, van Leeuwen, R, Jones, E A, Heymans, S & Papageorgiou, A-P 2018, ' SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis ', Matrix Biology . https://doi.org/10.1016/j.matbio.2018.04.015

Myocardial damage as a consequence of cardiotropic viruses leads to a broad variety of clinical presentations and is still a complicated condition to diagnose and treat. Whereas the extracellular matrix protein Secreted Protein Acidic and Rich in Cys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fef81b912213b9938fbab5cc5ad381b
https://lirias.kuleuven.be/handle/123456789/631698

Association of Kidney Function with Changes in the Endothelial Surface Layer

Autor: Marlies E.J. Reinders, Dae Hyun Lee, Johan van der Vlag, Martijn J. C. Dane, Margien G.S. Boels, Bernard M. van den Berg, Ton J. Rabelink, Angelique L.W.M.M. Rops, Jurgen W. G. E. van Teeffelen, Anton Jan van Zonneveld, Meriem Khairoun, Hans Vink, Bart Eskens

Publikováno v: Clinical Journal of the American Society of Nephrology
Clinical journal of the American Society of Nephrology, 9(4), 698-704. American Society of Nephrology
Clinical Journal of the American Society of Nephrology, 9, 698-704
Clinical Journal of the American Society of Nephrology, 9, 4, pp. 698-704
Clinical Journal of the American Society of Nephrology, 9(4), 698-704

Item does not contain fulltext BACKGROUND AND OBJECTIVES: ESRD is accompanied by endothelial dysfunction. Because the endothelial glycocalyx (endothelial surface layer) governs interactions between flowing blood and the vessel wall, perturbation coul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63050add97aaa862bf4cd2d1e2b7d8c0
https://doi.org/10.2215/cjn.08160813

Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice

Autor: Hans Vink, Bart Eskens, Coert J. Zuurbier, Jurgen W. G. E. van Teeffelen, Judith van Haare

Publikováno v: Cardiovascular diabetology, 12(1). BioMed Central
Cardiovascular Diabetology

Background The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has been indicated to have importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74afa46c313673dac44291c9246a8eec
https://doi.org/10.1186/1475-2840-12-175

Systemic adenosine‐induced impairment of endothelial glycocalyx barrier properties is associated with a reduction in functional capillary density in hindlimb skeletal muscle of rats

Autor: Hans Vink, Hanneke Cobelens, Judith van Haare, Bart Eskens, Jurgen W. G. E. van Teeffelen, Jack P.M. Cleutjens

Publikováno v: The FASEB Journal. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c8dd94017823351447dc17b9d8ab38
https://doi.org/10.1096/fasebj.26.1_supplement.855.3

Insulin selectively increases accessibility of small dextrans in capillaries of rat skeletal muscle: role for glycocalyx

Autor: Bart Eskens, Hans Vink, Judith van Haare, Jurgen W. G. E. van Teeffelen, Jack P.M. Cleutjens, Sjef Roos

Publikováno v: The FASEB Journal. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd1af5302b637ed07d75d37a9120b86b
https://doi.org/10.1096/fasebj.25.1_supplement.lb470