Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease

Autor: Bart De Taeye, L Harris Smith, Douglas E. Vaughan

Publikováno v: Current Opinion in Pharmacology. 5:149-154

A classical perspective of cardiovascular risk does not adequately account for all of the cardiovascular events associated with obesity and diabetes. The combination of hypertriglyceridemia, glucose intolerance and inflammation is linked with increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dcc821ae095bf40c7a4394b0a61c4f
https://doi.org/10.1016/j.coph.2005.01.007

Transgenic mice overexpressing renin exhibit glucose intolerance and diet-genotype interactions

Autor: Naima Moustaid-Moussa, Jung Han Kim, Nishan S. Kalupahana, Sarah Fletcher, Annie Quignard-Boulangé, Arnold M. Saxton, Brynn H. Voy, Morvarid Soltani-Bejnood, David H. Wasserman, Bart De Taeye

Publikováno v: Frontiers in Endocrinology, Vol 3 (2013)
Frontiers in Endocrinology
Frontiers in Endocrinology, Frontiers, 2013, 3, pp.166. ⟨10.3389/fendo.2012.00166⟩

Numerous animal and clinical investigations have pointed to a potential role of the renin-angiotensin system (RAS) in the development of insulin resistance and diabetes in conditions of expanded fat mass. However, the mechanisms underlying this assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7ea2d86847963139d0a57d71ba6647
http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00166/full

Use of Mouse Models to Study Plasminogen Activator Inhibitor-1

Autor: Bart De Taeye, Paul Declerck, Ann Gils

Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) and therefore plays an important role in the plasminogen/plasmin system. PAI-1 is involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ec1b14c1274860723f02c997e896fba
https://doi.org/10.1016/b978-0-12-386471-0.00005-5

Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue

Autor: Jun Yang, Sheila B. Murphy, Bruce B. Hammock, David B. Friedman, Ayala Luria, Bart De Taeye, Douglas E. Vaughan, Christophe Morisseau, Joseph W. Covington, Julie Coyle

Obesity is an increasingly important public health issue reaching epidemic proportions. Visceral obesity has been defined as an important element of the metabolic syndrome and expansion of the visceral fat mass has been shown to contribute to the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecd8b51c626241a34554dbfebc13986
https://europepmc.org/articles/PMC2864128/

Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity

Autor: Tatiana Novitskaya, Bart De Taeye, Douglas E. Vaughan, Owen P. McGuinness, Mousumi Medda, Joseph W. Covington, Linda A. Gleaves

Publikováno v: American journal of physiology. Endocrinology and metabolism. 293(3)

Obesity is commonly associated with development of insulin resistance and systemic evidence of inflammation. Macrophages contribute to inflammatory amplification in obesity and may contribute directly to insulin resistance and the development of nona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badb5fb8835d2b790dbfda74a48f71a5
https://pubmed.ncbi.nlm.nih.gov/17578885