Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Bart A Westerman"'
Autor:
Georgi K Kanev, Yaran Zhang, Albert J Kooistra, Andreas Bender, Rob Leurs, David Bailey, Thomas Würdinger, Chris de Graaf, Iwan J P de Esch, Bart A Westerman
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011301 (2023)
Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using multi-targeted drugs, we developed a machine learning pipeline to unravel the target landscape of
Externí odkaz:
https://doaj.org/article/3875d0fdcc1341ac8c4a8184e67a02c7
Autor:
Asli Küçükosmanoglu, Carolien L. van derBorden, Lisanne E. A. deBoer, Roel Verhaak, David Noske, Tom Wurdinger, Teodora Radonic, Bart A. Westerman
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2407-2422 (2024)
Genetic heterogeneity in tumors can show a remarkable selectivity when two or more independent genetic events occur in the same gene. This phenomenon, called composite mutation, points toward a selective pressure, which frequently causes therapy resi
Externí odkaz:
https://doaj.org/article/2f535455fe3d438d87cea860c9cbc6cf
Autor:
Bart A Westerman, Marleen Blom, Ellen Tanger, Martin van der Valk, Ji-Ying Song, Marije van Santen, Jules Gadiot, Paulien Cornelissen-Steijger, John Zevenhoven, Haydn M Prosser, Anthony Uren, Eleonora Aronica, Maarten van Lohuizen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35943 (2012)
Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types of cancer, including tumors of astroglial and neural
Externí odkaz:
https://doaj.org/article/6af8facbcc884638a76bf0cd182d6c29
Autor:
Fleur M.G. Cornelissen, Greta Markert, Ghislaine Deutsch, Maria Antonara, Noa Faaij, Imke Bartelink, David Noske, W. Peter Vandertop, Andreas Bender, Bart A. Westerman
Publikováno v:
Cornelissen, F M G, Markert, G, Deutsch, G, Antonara, M, Faaij, N, Bartelink, I, Noske, D, Vandertop, W P, Bender, A & Westerman, B A 2023, ' Explaining Blood-Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms ', Journal of Medicinal Chemistry, vol. 66, no. 11, pp. 7253-7267 . https://doi.org/10.1021/acs.jmedchem.2c01824
Journal of Medicinal Chemistry, 66(11), 7253-7267. American Chemical Society
Journal of Medicinal Chemistry, 66(11), 7253-7267. American Chemical Society
The blood-brain barrier (BBB) represents a major obstacle to delivering drugs to the central nervous system (CNS), resulting in the lack of effective treatment for many CNS diseases including brain cancer. To accelerate CNS drug development, computat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b91f90bfcf0cc32a4d1e0e2eada5cf
https://research.vumc.nl/en/publications/571eee73-d460-4f59-890e-91146974e9b6
https://research.vumc.nl/en/publications/571eee73-d460-4f59-890e-91146974e9b6
Autor:
Peter Sminia, Jan Theys, Bart A. Westerman, Brigitta G. Baumert, Lukas J.A. Stalpers, Daphne A. Haas-Kogan, Tom Würdinger, Ben J. Slotman, Jaap van den Berg, Rogier Dik, Hou Y.Y.E. Veldman, Tonny Lagerweij, Fleur M.G. Cornelissen, Paul L.G. Slangen, Ana Gasol, Ravi S. Narayan
Supplemental Figure 1. Chemical structures of non-FDA approved compounds used in the Study; Supplemental Figure 2. Effect of drugs on growth and target phosphorylation; Supplemental Figure 3. mTOR inhibition does not show dose dependent Radiosensitiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc0c910cffbb13d392e1d82fa7f189d
https://doi.org/10.1158/1535-7163.22504666.v1
https://doi.org/10.1158/1535-7163.22504666.v1
Autor:
Peter Sminia, Jan Theys, Bart A. Westerman, Brigitta G. Baumert, Lukas J.A. Stalpers, Daphne A. Haas-Kogan, Tom Würdinger, Ben J. Slotman, Jaap van den Berg, Rogier Dik, Hou Y.Y.E. Veldman, Tonny Lagerweij, Fleur M.G. Cornelissen, Paul L.G. Slangen, Ana Gasol, Ravi S. Narayan
Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K and MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not in combination with radiotherapy, which is a key component of the current standard treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99956e3c52b0c80f5b93b220beab0d8d
https://doi.org/10.1158/1535-7163.c.6537823.v1
https://doi.org/10.1158/1535-7163.c.6537823.v1
Publikováno v:
Scoarta, S, Küçükosmanoglu, A, Bindt, F, Pouwer, M & Westerman, B A 2023, ' Review : A Roadmap to Use Nonstructured Data to Discover Multitarget Cancer Therapies ', JCO clinical cancer informatics, vol. 7, pp. e2200096 . https://doi.org/10.1200/CCI.22.00096
Therapy resistance to single agents has led to the realization that combination therapies could become the cornerstone of cancer treatment. To operationalize the selection of effective and safe multitarget therapies, we propose to integrate chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5064327ce145f5121e2f78108098ddd8
http://www.scopus.com/inward/record.url?scp=85159241760&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85159241760&partnerID=8YFLogxK
Autor:
Frederick S. Varn, Kevin C. Johnson, Jan Martinek, Jason T. Huse, MacLean P. Nasrallah, Pieter Wesseling, Lee A.D. Cooper, Tathiane M. Malta, Taylor E. Wade, Thais S. Sabedot, Daniel Brat, Peter V. Gould, Adelheid Wöehrer, Kenneth Aldape, Azzam Ismail, Santhosh K. Sivajothi, Floris P. Barthel, Hoon Kim, Emre Kocakavuk, Nazia Ahmed, Kieron White, Indrani Datta, Hyo-Eun Moon, Steven Pollock, Christine Goldfarb, Ga-Hyun Lee, Luciano Garofano, Kevin J. Anderson, Djamel Nehar-Belaid, Jill S. Barnholtz-Sloan, Spyridon Bakas, Annette T. Byrne, Fulvio D’Angelo, Hui K. Gan, Mustafa Khasraw, Simona Migliozzi, D. Ryan Ormond, Sun Ha Paek, Erwin G. Van Meir, Annemiek M.E. Walenkamp, Colin Watts, Tobias Weiss, Michael Weller, Karolina Palucka, Lucy F. Stead, Laila M. Poisson, Houtan Noushmehr, Antonio Iavarone, Roel G.W. Verhaak, Kristin D. Alfaro, Samirkumar B. Amin, David M. Ashley, Christoph Bock, Andrew Brodbelt, Ketan R. Bulsara, Ana Valeria Castro, Jennifer M. Connelly, Joseph F. Costello, John F. de Groot, Gaetano Finocchiaro, Pim J. French, Anna Golebiewska, Ann C. Hau, Chibo Hong, Craig Horbinski, Kasthuri S. Kannan, Mathilde CM. Kouwenhoven, Anna Lasorella, Peter S. LaViolette, Keith L. Ligon, Allison K. Lowman, Shwetal Mehta, Hrvoje Miletic, Annette M. Molinaro, Ho Keung Ng, Simone P. Niclou, Johanna M. Niers, Joanna J. Phillips, Raul Rabadan, Ganesh Rao, Guido Reifenberger, Nader Sanai, Susan C. Short, Peter Sillevis Smitt, Andrew E. Sloan, Marion Smits, James M. Snyder, Hiromichi Suzuki, Ghazaleh Tabatabai, Georgette Tanner, William H. Tomaszewski, Michael Wells, Bart A. Westerman, Helen Wheeler, Jichun Xie, W.K. Alfred Yung, Gelareh Zadeh, Junfei Zhao, Roel GW. Verhaak
Publikováno v:
Cell, 185(12), 2184-2199.e16. Cell Press
Cell
Cell, vol 185, iss 12
The GLASS Consortium 2022, ' Glioma progression is shaped by genetic evolution and microenvironment interactions ', Cell, vol. 185, no. 12, pp. 2184-2199.e16 . https://doi.org/10.1016/j.cell.2022.04.038
Cell, 185(12), 2184-2199.e16. CELL PRESS
Cell
Cell, vol 185, iss 12
The GLASS Consortium 2022, ' Glioma progression is shaped by genetic evolution and microenvironment interactions ', Cell, vol. 185, no. 12, pp. 2184-2199.e16 . https://doi.org/10.1016/j.cell.2022.04.038
Cell, 185(12), 2184-2199.e16. CELL PRESS
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aa8231290284197e37208bfab4dbba
https://research.vumc.nl/en/publications/312bbb0a-1328-4405-bfbe-cce4f07b8a67
https://research.vumc.nl/en/publications/312bbb0a-1328-4405-bfbe-cce4f07b8a67
Autor:
Gerard C. Krijger, Sarah M. Jacobs, Tom J. Snijders, Bart de Keizer, Pieter Wesseling, Pierre A. Robe, Bart A. Westerman, Anja G. van der Kolk, Nelleke Tolboom, F. F. Tessa Ververs
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 49, 2, pp. 481-491
European Journal of Nuclear Medicine and Molecular Imaging, 49, 481-491
European Journal of Nuclear Medicine and Molecular Imaging. Springer Verlag
Jacobs, S M, Wesseling, P, de Keizer, B, Tolboom, N, Ververs, F F T, Krijger, G C, Westerman, B A, Snijders, T J, Robe, P A & van der Kolk, A G 2021, ' CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [68Ga]Ga-Pentixafor /[177Lu]Lu-Pentixather ', European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-021-05196-4, https://doi.org/10.1007/s00259-021-05196-4
European Journal of Nuclear Medicine and Molecular Imaging, 49, 2, pp. 481-491
European Journal of Nuclear Medicine and Molecular Imaging, 49, 481-491
European Journal of Nuclear Medicine and Molecular Imaging. Springer Verlag
Jacobs, S M, Wesseling, P, de Keizer, B, Tolboom, N, Ververs, F F T, Krijger, G C, Westerman, B A, Snijders, T J, Robe, P A & van der Kolk, A G 2021, ' CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [68Ga]Ga-Pentixafor /[177Lu]Lu-Pentixather ', European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-021-05196-4, https://doi.org/10.1007/s00259-021-05196-4
Purpose CXCR4 (over)expression is found in multiple human cancer types, while expression is low or absent in healthy tissue. In glioblastoma it is associated with a poor prognosis and more extensive infiltrative phenotype. CXCR4 can be targeted by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e0fa5839a081f199068562f7a3e623
https://doi.org/10.1007/s00259-021-05196-4
https://doi.org/10.1007/s00259-021-05196-4
Publikováno v:
Kanev, G K, de Graaf, C, Westerman, B A, de Esch, I J P & Kooistra, A J 2021, ' KLIFS : an overhaul after the first 5 years of supporting kinase research ', Nucleic acids research, vol. 49, no. D1, pp. D562-D569 . https://doi.org/10.1093/nar/gkaa895
Nucleic Acids Research
Kanev, G K, de Graaf, C, Westerman, B A, de Esch, I J P & Kooistra, A J 2021, ' KLIFS : an overhaul after the first 5 years of supporting kinase research ', Nucleic Acids Research, vol. 49, no. D1, pp. D562-D569 . https://doi.org/10.1093/nar/gkaa895
Nucleic Acids Research, 49(D1), D562-D569. Oxford University Press
Nucleic acids research, 49(D1), D562-D569. Oxford University Press
Nucleic Acids Research
Kanev, G K, de Graaf, C, Westerman, B A, de Esch, I J P & Kooistra, A J 2021, ' KLIFS : an overhaul after the first 5 years of supporting kinase research ', Nucleic Acids Research, vol. 49, no. D1, pp. D562-D569 . https://doi.org/10.1093/nar/gkaa895
Nucleic Acids Research, 49(D1), D562-D569. Oxford University Press
Nucleic acids research, 49(D1), D562-D569. Oxford University Press
Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family, a wealth of data has been accumulated that keeps on growing. KLIFS—Kinase–Ligand Interaction Fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2f7dd0777f5c73b8e9a26f6c1033b
http://www.scopus.com/inward/record.url?scp=85099428687&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85099428687&partnerID=8YFLogxK