Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Bart, Vandekerckhove"'
Autor:
Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the activity of various transcription factors, such as members of the Hairy/Enhancer of Split (
Externí odkaz:
https://doaj.org/article/2ba793734fde41f4aa47b970e723784c
Autor:
Melissa Pille, John M. Avila, So Hyun Park, Cuong Q. Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J. Shpall, Gang Bao, Bart Vandekerckhove, Brian R. Davis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101208- (2024)
Wiskott-Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency resulting from a diversity of mutations distributed across all 12 exons of the WAS gene. WAS encodes a hematopoietic-specific and developmentally regulated cytoplasmic prote
Externí odkaz:
https://doaj.org/article/c869b7adf0164810aa0dd2b9dccebba3
Autor:
Guillem Sanchez Sanchez, Maria Papadopoulou, Abdulkader Azouz, Yohannes Tafesse, Archita Mishra, Jerry K. Y. Chan, Yiping Fan, Isoline Verdebout, Silvana Porco, Frédérick Libert, Florent Ginhoux, Bart Vandekerckhove, Stanislas Goriely, David Vermijlen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Knowledge about the ontogeny of T cells in the thymus relies heavily on mouse studies because of difficulty to obtain human material. Here the authors perform a single cell analysis of thymocytes from human fetal and paediatric thymic samples to char
Externí odkaz:
https://doaj.org/article/6dfe7ee0d486441f82161526cf2ca7ec
Autor:
Rupert L. Mayer, Rein Verbeke, Caroline Asselman, Ilke Aernout, Adillah Gul, Denzel Eggermont, Katie Boucher, Fabien Thery, Teresa M. Maia, Hans Demol, Ralf Gabriels, Lennart Martens, Christophe Bécavin, Stefaan C. De Smedt, Bart Vandekerckhove, Ine Lentacker, Francis Impens
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Currently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice.
Externí odkaz:
https://doaj.org/article/97f012cb13b5447e97faef124f7e4dca
Autor:
Melissa Pille, John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Joline Ingels, Laurenz De Cock, Eva Pascal, Lucas Deseins, Tessa Kerre, Tom Taghon, Georges Leclercq, David Vermijlen, Brian Davis, Bart Vandekerckhove
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections
Externí odkaz:
https://doaj.org/article/8e328ea3407848819b605b95f452cf7f
Autor:
Eva Persyn, Sigrid Wahlen, Laura Kiekens, Wouter Van Loocke, Hannah Siwe, Els Van Ammel, Zenzi De Vos, Filip Van Nieuwerburgh, Patrick Matthys, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes that play an important role in the first line of defense against malignant or virus-infected cells. A better understanding of the transcriptional regulation of human NK cell d
Externí odkaz:
https://doaj.org/article/74d32dc0a813471ba26a5d908fb198a5
Autor:
Laurens Raes, Melissa Pille, Aranit Harizaj, Glenn Goetgeluk, Jelter Van Hoeck, Stephan Stremersch, Juan C. Fraire, Toon Brans, Olivier Gerrit de Jong, Roel Maas-Bakker, Enrico Mastrobattista, Pieter Vader, Stefaan C. De Smedt, Bart Vandekerckhove, Koen Raemdonck, Kevin Braeckmans
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 696-707 (2021)
The CRISPR-Cas9 technology represents a powerful tool for genome engineering in eukaryotic cells, advancing both fundamental research and therapeutic strategies. Despite the enormous potential of the technology, efficient and direct intracellular del
Externí odkaz:
https://doaj.org/article/d83a80530b204562bf8701e1aa7bfddd
Autor:
Laura Kiekens, Sigrid Wahlen, Eva Persyn, Zenzi De Vos, Tom Taghon, Bart Vandekerckhove, Georges Leclercq
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Type 3 innate lymphoid cells (ILC3s) are characterized by RORγt expression and they produce IL-22 upon activation. ILC3s play a role in maintenance of barrier integrity in the intestine. Under inflammatory conditions, the ILC composition of the muco
Externí odkaz:
https://doaj.org/article/316457670910498e83a1cf40ab015611
Autor:
Juliette Roels, Jolien Van Hulle, Marieke Lavaert, Anna Kuchmiy, Steven Strubbe, Tom Putteman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Lena Boehme, Tom Taghon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T cells are generated from hematopoietic stem cells through a highly organized developmental process, in which stage-specific molecular events drive maturation towards αβ and γδ T cells. Although many of the mechanisms that control αβ- and γδ
Externí odkaz:
https://doaj.org/article/6524a9a239ef461a8c7a071eff7c8676
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
Autor:
Sigrid Wahlen, Filip Matthijssens, Wouter Van Loocke, Sylvie Taveirne, Laura Kiekens, Eva Persyn, Els Van Ammel, Zenzi De Vos, Stijn De Munter, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Publikováno v:
eLife, Vol 11 (2022)
Natural killer (NK) cells are innate lymphocytes that eliminate virus-infected and cancer cells by cytotoxicity and cytokine secretion. In addition to circulating NK cells, distinct tissue-resident NK subsets have been identified in various organs. A
Externí odkaz:
https://doaj.org/article/11397126237f4caebcb161863a688e20