Výsledky vyhledávání - "Barry W. Siegel"

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

Autor: Salituro Francesco G, Vicki L. Taylor, Barry W. Siegel, Bruce M. Baron, John H. Kehne, Yaw Senyah, Harrison Boyd L, H.Steven White, Paul L.M. Van Giersbergen, Phillip L. Nyce, Christopher J. Schmidt, Michael Murawsky, Gina M. Fadayel, Timothy C. McCloskey

Publikováno v: European Journal of Pharmacology. 323:181-192

MDL 105,519, ( E )-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H -indole-2-carboxylic acid, is a potent and selective inhibitor of [ 3 H]glycine binding to the NMDA receptor. MDL 105,519 inhibits NMDA ( N -methyl- d -aspartate)-dependent responses i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea8d87937b04bbd1e28a1154c486add
https://doi.org/10.1016/s0014-2999(97)00045-9

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A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

Autor: Timothy W. Lovenberg, Margaret M. Racke, Bruce M. Baron, Amy L. Slone, Patria E. Danielson, Mark G. Erlander, Pamela E. Foye, Michael A. Rea, Joseph D. Miller, Rebecca A. Prosser, Barry W. Siegel, J. Gregor Sutcliffe, Luis de Lecea

Publikováno v: Neuron. 11:449-458

We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT 7 , which is coupled to the stimulation of adenylyl cyclase. 5-HT 7 mRNA is expressed discretely throughout the CNS, predominantly in the thalamus and hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96db837b54cec7fe8359f9b0d4c1157f
https://doi.org/10.1016/0896-6273(93)90149-l

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Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma × glioma cells

Autor: Martin Galvan, Peter H. Boeijinga, Barry W. Siegel, Amy L. Slone, Mark W. Dudley, Bruce M. Baron

Publikováno v: European Journal of Pharmacology. 219:9-13

In radioligand binding experiments, MDL 73147EF and MDL 74156 inhibited the binding of [ 3 H]GR65630 to 5-hydroxytryptamine 3 (5-HT 3 ) binding sites on membranes prepared from NG108-15 neuroblastoma × glioma cells. The calculated dissociation const

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b4fee6f1e8c2104237b0ef2045ce4
https://doi.org/10.1016/0014-2999(92)90573-m

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[3H]MDL 100,907: a novel selective 5-HT2A receptor ligand

Autor: Albert A. Carr, Barry W. Siegel, Michael P. Johnson

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 354

In studies using standard radioligands, unlabeled MDL 100,907 (R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol) has been shown to have a high degree of selectivity for the 5-HT2A receptor. The present study was und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931d37c6d00171317f8dff74482d75be
https://doi.org/10.1007/bf00178722

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Activities of novel aryloxyalkylimidazolines on rat 5-HT2A and 5-HT2C receptors

Autor: Jules Freedman, Barry W. Siegel, Bruce M. Baron, Mark J. Vaal

Publikováno v: European journal of pharmacology. 296(3)

Using transfected NIH 3T3 mouse fibroblast cell lines expressing the rat 5-HT2A and rat 5-HT2C receptor subtypes, and techniques of 2-[125I](+)-iodolysergic acid diethylamide ([125I]LSD) binding and serotonin (5-hydroxytryptamine, 5-HT)-stimulated ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28fa85b0bb92e3d41b974a0d1256515
https://pubmed.ncbi.nlm.nih.gov/8904083

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MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles

Autor: Amy L. Slone, Matthieu Poirot, Barry W. Siegel, Bruce M. Baron, Harrison Boyd L, Salituro Francesco G, Timothy C. McCloskey, John H. Kehne, Michael G. Palfreyman, H.Steven White, Paul L.M. van Giersbergen

Publikováno v: European journal of pharmacology. 284(1-2)

Glycine receptor antagonists have been proposed to have multiple therapeutic applications, including the treatment of stroke, epilepsy, and anxiety. The present study compared the biochemical and behavioral profiles of two strychnine-insensitive glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f36c9360ec400b0c860d624cd07e9cc
https://pubmed.ncbi.nlm.nih.gov/8549613

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[3H]5,7-dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites

Autor: Bruce M. Baron, Harrison Boyd L, Amy L. Slone, Stephen D. Hurt, Barry W. Siegel, Michael G. Palfreyman

Publikováno v: European journal of pharmacology. 206(2)

A strychnine-insensitive glycine binding site is located on the N-methyl- d -aspartate (NMDA)-preferring glutamate receptor complex. Kynurenic acid analogs are antagonists at this binding site. A derivative of kynurenic acid, 5,7-dichlorokynurenic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66b8fc14804604beff9d61e5791afc1
https://pubmed.ncbi.nlm.nih.gov/1829684

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Cilia Regeneration in the Sea Urchin Embryo: Evidence for a Pool of Ciliary Proteins

Autor: Barry W. Siegel, Walter Auclair

Publikováno v: Science. 154:913-915

Late gastrulae of paracentrotus lividus regenerated cilia after being deciliated in hypertonic sea water. Regeneration was not affected by actinomycin D or puromycin. Actinomycin D also did not affect ciliary protein synthesis during regeneration, al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aea469441ed17aa84d4ff4e5649fb9e
https://doi.org/10.1126/science.154.3751.913

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Rapid down regulation of beta-adrenoceptors by co-administration of desipramine and fluoxetine

Autor: Barry W. Siegel, Bruce M. Baron, Mark W. Dudley, Ann-Marie Ogden, Richard C. Ursillo, James Stegeman

Publikováno v: European journal of pharmacology. 154(2)

Co-administration of desipramine and fluoxetine resulted in a 27% decline in cerebral cortical beta-adrenoceptor density after four days - a time point at which neither agent alone was effective. After 14 days, desipramine- and desipramine + fluoxeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970726a1423219cfdd8eb3e51b4e80b4
https://pubmed.ncbi.nlm.nih.gov/2465908

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Alpha 2-adrenergic and muscarinic cholinergic receptors have opposing actions on cyclic AMP levels in SK-N-SH human neuroblastoma cells

Autor: Bruce M. Baron, Barry W. Siegel

Publikováno v: Journal of neurochemistry. 53(2)

Forskolin and vasoactive intestinal polypeptide (VIP) were shown to increase cyclic AMP accumulation in a human neuroblastoma cell line, SK-N-SH cells. The α2-adrenergic agonist UK 14304 decreased forskolin-stimulated cyclic AMP levels by 40 ± 2%,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4728ed7df8e54dc5c942d59c537372bf
https://pubmed.ncbi.nlm.nih.gov/2545824

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