Zobrazeno 1 - 10
of 597
pro vyhledávání: '"Barry V. L. Potter"'
Autor:
María Ángeles Márquez-Moñino, Raquel Ortega-García, Hayley Whitfield, Andrew M. Riley, Lourdes Infantes, Shane W. Garrett, Megan L. Shipton, Charles A. Brearley, Barry V. L. Potter, Beatriz González
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract d-myo-inositol 1,4,5-trisphosphate (InsP3) is a fundamental second messenger in cellular Ca2+ mobilization. InsP3 3-kinase, a highly specific enzyme binding InsP3 in just one mode, phosphorylates InsP3 specifically at its secondary 3-hydroxy
Externí odkaz:
https://doaj.org/article/2e9f8695a0ad4929bc5af1359e3b8bdc
Autor:
Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter, Henning J. Jessen, Stephen B. Shears
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive m
Externí odkaz:
https://doaj.org/article/80727188fe0e4b42b9d3d714ec578029
Autor:
Ylana Adami Franco, Manoel Oliveira de Moraes, Larissa A. C. Carvalho, Wolfgang Dohle, Renaira Oliveira da Silva, Isabella Harumi Yonehara Noma, Keli Lima, Barry V. L. Potter, João A. Machado-Neto, Silvya Stuchi Maria-Engler
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11314 (2023)
The endogenous estradiol derivative 2-Methoxyestradiol (2-ME) has shown good and wide anticancer activity but suffers from poor oral bioavailability and extensive metabolic conjugation. However, its sulfamoylated derivative, 2-methoxyestradiol-3,17-O
Externí odkaz:
https://doaj.org/article/b68f60ce70a9417ab3d6190a93e3a97e
Autor:
Ruqaiyyah Siddiqui, Mutasem Rawas-Qalaji, Mohammed I. El-Gamal, Sreedevi Sajeev, Jayalakshmi Jagal, Seyed-Omar Zaraei, Rawan M. Sbenati, Hanan S. Anbar, Wolfgang Dohle, Barry V. L. Potter, Naveed Ahmed Khan
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 561 (2023)
Pathogenic Acanthamoeba produce keratitis and fatal granulomatous amoebic encephalitis. Treatment remains problematic and often ineffective, suggesting the need for the discovery of novel compounds. For the first time, here we evaluated the effects o
Externí odkaz:
https://doaj.org/article/0da6281f7cec4bbeb9db39af0ce89405
Publikováno v:
Molecules, Vol 28, Iss 1, p 5 (2022)
A series of benzyl, phenyl guanidine, and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were determined. Several compounds s
Externí odkaz:
https://doaj.org/article/ab14a0c87a6a4915b904d7b8d43562f3
Autor:
Xiangdong Su, Wolfgang Dohle, Stephen J. Mills, Joanna M. Watt, Ana M. Rossi, Colin W. Taylor, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 5, Iss 44, Pp 28793-28811 (2020)
Externí odkaz:
https://doaj.org/article/d94ccb6b6c4f468785da8db2c6a81162
Autor:
Yu-chi Shen, Caroline Arellano-Garcia, Rosa E. Menjivar, Ethan M. Jewett, Wolfgang Dohle, Sofiia Karchugina, Jonathan Chernoff, Barry V. L. Potter, Kate F. Barald
Publikováno v:
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. Ne
Externí odkaz:
https://doaj.org/article/b9dd4fca873e4e1ead8dd4443ae8ad79
Autor:
Scott D. Hargrave, Anna M. Joubert, Barry V. L. Potter, Wolfgang Dohle, Sumari Marais, Anne E. Mercier
Publikováno v:
Molecules, Vol 27, Iss 12, p 3819 (2022)
A tetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule dynamic instability paramete
Externí odkaz:
https://doaj.org/article/2684b04f1f7c4b30b6276ffafcb5e169
Autor:
Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 755-764 (2019)
Externí odkaz:
https://doaj.org/article/25fe86c26b2f41b2afb5b7ee20b13b6c
Autor:
Dharshini Ganeshapillai, L. W. Lawrence Woo, Mark P. Thomas, Atul Purohit, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 10748-10772 (2018)
Externí odkaz:
https://doaj.org/article/2e29194f912d47a5a2b1bbe6f389e480