Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Barry Teobald"'
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279
Autor:
Alastair J. H. Brown, Sophie J. Bradley, Giles A. Brown, Kirstie A. Bennett, Jason Brown, Julie E. Cansfield, David M. Cross, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg Osbourne, Jayesh C. Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael Browning, Francesca Perini, Gerard R. Dawson, John F. W. Deakin, Robert T. Smith, Patrick M. Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G. Tehan, Barry Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Robert M. Cooke, Fiona H. Marshall, Prakash Rucktooa, Miles S. Congreve, Malcolm Weir, Andrew Tobin
Publikováno v:
SSRN Electronic Journal.
Current therapies for improving memory in Alzheimer’s disease are focused on correcting for defective cholinergic transmission by increasing acetylcholine levels through inhibition of acetylcholinesterase enzymes. These treatments are however assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9223ad5ca22fdc8ece3f25838d310314
https://doi.org/10.2139/ssrn.3641933
https://doi.org/10.2139/ssrn.3641933
Autor:
Iain Walters, John Steele, Timothy Johnson, Andrew Baxter, Nicholas Kindon, David Cheshire, Antonio Mete, John Unitt, Glen Andrews, Yu-Zhen Liu, Dermot F. McGinnity, Bryan Roberts, Michael J. Stocks, Paul Hemsley, Barry Teobald, Mark McHale, James Reuberson, Deborah Vaughan
Publikováno v:
ACS medicinal chemistry letters. 8(9)
N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS) of a subset of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf60bc07dc526ae8f2f4763a991e6eaa
https://pubmed.ncbi.nlm.nih.gov/28947948
https://pubmed.ncbi.nlm.nih.gov/28947948
Autor:
Barry Teobald
Publikováno v:
Tetrahedron. 58:4133-4170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cab261af082c2158cd1f1c875dfd0d1
https://doi.org/10.1016/s0040-4020(02)00315-0
https://doi.org/10.1016/s0040-4020(02)00315-0
Autor:
Anthony Ingall, Brian Springthorpe, Simon Guile, Chapman David, Paul D. Leeson, Timothy Nicholas Birkinshaw, Garry Pairaudeau, Simon F. Hunt, John Dixon, Michael Mortimore, Richard J. Lewis, Barry Teobald, Dermot F. McGinnity, Brown Roger Charles, Stuart W. Paine, Anil Patel, Robert J. Riley, Francis Ince, Wendy Tomlinson, Kirk Ian, Roger Bonnert, Andrew Bailey, Aaron Rigby, Patrick Barton, Paul Willis, Barrie Martin, P. Leff, R.G. Humphries, Peter J. H. Webborn
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described. Modifications of the acidic side chain and the purine core and investigation of hydrophobic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6951535cd7d2c326d389158dd07fcea
https://pubmed.ncbi.nlm.nih.gov/17827008
https://pubmed.ncbi.nlm.nih.gov/17827008
Autor:
Simon F. Hunt, Jane A. Clegg, Barry Teobald, Paul Willis, David Cox, Andrew Bailey, James A. Smith, John Dixon, Wendy Tomlinson, Mandy E. Coombs, P. Leff, R.G. Humphries, Anthony Ingall, Nicholas Kindon, Judith I. McInally
Publikováno v:
Journal of medicinal chemistry. 42(2)
The platelet P2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as antithrombotic agents. We have explored analogues of adenosine triphosphate (ATP), which is a weak, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60046b6c49c6ee589ed26bd16eb28ec8
https://pubmed.ncbi.nlm.nih.gov/9925726
https://pubmed.ncbi.nlm.nih.gov/9925726