Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Barry T Rouse"'
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191533 (2018)
Activation of CD4 T cells leads to their metabolic reprogramming which includes enhanced glycolysis, catalyzed through hexokinase enzymes. Studies in some systems indicate that the HK2 isoform is the most up regulated isoform in activated T cells and
Externí odkaz:
https://doaj.org/article/50ffb849f64840cfaf9da62dd48abcc8
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0141925 (2015)
The cornea is a complex tissue that must preserve its transparency to maintain optimal vision. However, in some circumstances, damage to the eye can result in neovascularization that impairs vision. This outcome can occur when herpes simplex virus ty
Externí odkaz:
https://doaj.org/article/18f5b33931494248a5fdbb66b8c56e26
Autor:
Pradeep B J Reddy, Sharvan Sehrawat, Amol Suryawanshi, Naveen K Rajasagi, Madhu Khatri, Barry T Rouse
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98051 (2014)
Long-term treatment with the fungal metabolite drug FTY720 (Fingolimod) was shown to be highly effective in controlling viral immunopathological lesions. However, in this report we show that the anti-inflammatory effect of FTY720 in herpes simplex vi
Externí odkaz:
https://doaj.org/article/45374c5dcc024ed9ad157551a3ff5b1d
Autor:
Chuan-Liang Kao, Ta-Chien Chan, Chu-Han Tsai, Kuan-Ying Chu, Shu-Fang Chuang, Chang-Chun Lee, Zheng-Rong Tiger Li, Ko-Wen Wu, Luan-Yin Chang, Yea-Huei Shen, Li-Min Huang, Ping-Ing Lee, Chinglai Yang, Richard Compans, Barry T Rouse, Chwan-Chuen King
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31162 (2012)
The 2009 influenza pandemic provided an opportunity to observe dynamic changes of the hemagglutinin (HA) and neuraminidase (NA) of pH1N1 strains that spread in two metropolitan areas--Taipei and Kaohsiung. We observed cumulative increases of amino ac
Externí odkaz:
https://doaj.org/article/7a394ad3300a4acdba3f2d06f99b734f
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002427 (2011)
Ocular herpes simplex virus infection can cause a blinding CD4⁺ T cell orchestrated immuno-inflammatory lesion in the cornea called Stromal Keratitis (SK). A key to controlling the severity of SK lesions is to suppress the activity of T cells that
Externí odkaz:
https://doaj.org/article/94b521aca9d34e439780bd5843dfd551
Autor:
Sharvan Sehrawat, Pradeep B J Reddy, Naveen Rajasagi, Amol Suryawanshi, Mitsuomi Hirashima, Barry T Rouse
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000882 (2010)
In this communication, we demonstrate that galectin (Gal)-9 acts to constrain CD8(+) T cell immunity to Herpes Simplex Virus (HSV) infection. In support of this, we show that animals unable to produce Gal-9, because of gene knockout, develop acute an
Externí odkaz:
https://doaj.org/article/f5610f42d8f047f5b196c4614e0ef437
Autor:
Shalini Sharma, Naveen Kumar, Barry T. Rouse, Khushbu Sharma, Kundan Kumar Chaubey, ShoorVir Singh, Praveen Kumar, Pradeep Kumar
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28663- (2024)
Immune exhaustion is a state of immune cell dysfunction that occurs most commonly following chronic exposure to an antigen which persists after the immune response fails to remove it. Exhaustion has been studied most thoroughly with several cancers,
Externí odkaz:
https://doaj.org/article/e3e05b89960a46f686f634a2bbbc2f68
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3935 (2024)
The mission of this review is to identify immune-damaging participants involved in antiviral immunoinflammatory lesions. We argue these could be targeted and their activity changed selectively by maneuvers that, at the same time, may not diminish the
Externí odkaz:
https://doaj.org/article/4974dde0f58f495a90bb3f4877c5f394
Publikováno v:
Pathogens, Vol 12, Iss 3, p 437 (2023)
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory neurons and undergoes lifelong latency in the trigeminal gangli
Externí odkaz:
https://doaj.org/article/e77fef5996cb47278471a3fc69a1c4dc
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
When viruses infect cells, they almost invariably cause metabolic changes in the infected cell as well as in several host cell types that react to the infection. Such metabolic changes provide potential targets for therapeutic approaches that could r
Externí odkaz:
https://doaj.org/article/b0476884a1c6465190f51bef523ca751