Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Barry Sleno"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Erythromycin esterases (Eres) cleave the macrolactone ring of macrolides, a class of widely used antibiotics. Structures of EreC, in silico flexible docking studies and previous mutagenesis data lead to the proposal of a detailed catalytic mechanism
Externí odkaz:
https://doaj.org/article/7b2d872b0cc04ef1b3ff7eb82c9ff6ed
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Macrolides are a class of antibiotics widely used in both medicine and agriculture. Unsurprisingly, as a consequence of their exensive usage a plethora of resistance mechanisms have been encountered in pathogenic bacteria. One of these resistance mec
Autor:
Annette Herscovics, P. Lynne Howell, Bomina Yu, Yuri D. Lobsanov, Pedro A. Romero, Patrick Yip, Barry Sleno
Publikováno v:
Journal of Biological Chemistry. 279:17921-17931
Kre2p/Mnt1p is a Golgi alpha1,2-mannosyltransferase involved in the biosynthesis of Saccharomyces cerevisiae cell wall glycoproteins. The protein belongs to glycosyltransferase family 15, a member of which has been implicated in virulence of Candida
Autor:
Annette Herscovics, François Vallée, Patrick Yip, P. Lynne Howell, Barry Sleno, Francesco Lipari
Publikováno v:
The EMBO Journal. 19:581-588
Mannose trimming is not only essential for N-glycan maturation in mammalian cells but also triggers degradation of misfolded glycoproteins. The crystal structure of the class I alpha1, 2-mannosidase that trims Man(9)GlcNAc(2) to Man(8)GlcNAc(2 )isome
Publikováno v:
Glycobiology. 4:135-140
The alpha-1,6-mannosyltransferase (alpha-1,6-ManT) that initiates outer chain synthesis in Saccharomyces cerevisiae was partially purified along with an alpha-1,2-mannosyltransferase (alpha-1,2-ManT) that acts on alpha-methylmannoside. The enzymes we
Autor:
Linda O. Tremblay, Ikuo Wada, Annette Herscovics, Yukiko Kamiya, Kazuhiro Nagata, Koichi Kato, Barry Sleno, Nobuko Hosokawa
Publikováno v:
Glycobiology. 20(5)
Glycoprotein folding and degradation in the endoplasmic reticulum (ER) is mediated by the ER quality control system. Mannose trimming plays an important role by forming specific N-glycans that permit the recognition and sorting of terminally misfolde
Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis
Autor:
Yuri D, Lobsanov, Pedro A, Romero, Barry, Sleno, Bomina, Yu, Patrick, Yip, Annette, Herscovics, P Lynne, Howell
Publikováno v:
The Journal of biological chemistry. 279(17)
Kre2p/Mnt1p is a Golgi alpha1,2-mannosyltransferase involved in the biosynthesis of Saccharomyces cerevisiae cell wall glycoproteins. The protein belongs to glycosyltransferase family 15, a member of which has been implicated in virulence of Candida