Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Barry Sidney Orlek"'
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Synthesis of α-silylalkylbenzoxazoles and oxazoles from stable silylketenes
Autor: Barry Sidney Orlek, James T. Steer, Stephen P. Marsden
Publikováno v: Tetrahedron. 65:5503-5512
Stable silylketenes, prepared by rhodium-catalysed decomposition of silyldiazoketones, undergo addition/cyclocondensation sequences with aminophenols and aminomalonate to give α-silylalkylbenzoxazoles and oxazoles, respectively. The silicon can be r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75b76569c8b18a985ac32b06092dd308
https://doi.org/10.1016/j.tet.2009.03.105
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5
A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition
Autor: John David Harling, Barry Sidney Orlek
Publikováno v: Tetrahedron. 54:14905-14912
3-Substituted hexahydroindeno[2,1-b]pyrroles were prepared in a stereoselective manner in high yield via an intramolecular azomethine ylide cycloaddition. Olefin geometry in the ylide precursor controlled the stereochemistry at the 3-position.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf740f23bce07ab9d020dfd18d3882d
https://doi.org/10.1016/s0040-4020(98)00932-6
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6
Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere
Autor: Frederick Cassidy, Julie Hawkins, Barry Sidney Orlek, Steven Mark Bromidge, Christopher B. Naylor, Frank Brown, Michael S. G. Clark, Loudon Julia Mary, Michael S. Hadley, Graham J. Riley, Steven Dabbs
Publikováno v: Journal of Medicinal Chemistry. 40:4265-4280
Loss of cholinergic function is believed to be implicated in the cognitive decline associated with senile dementia of the Alzheimer type (SDAT). The disease is characterized by progressive loss of muscarinic receptors located on nerve terminals while
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff9388fbee61638fba8b02c20f5bc46
https://doi.org/10.1021/jm9702903
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7
Stereoselective construction of vicinal diamines. Part 3.1 Routes to the benz[ f ]indeno[1,7-bc] azepine and benz[e]indeno[2,1-b][1,4]diazepine ring systems
Autor: Barry Sidney Orlek, Eleanor A. Crowe
Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2775-2778
The trans-1-anilino-2-aminoindane derivative 2a derived from the adduct 1 of indene and N,N-dichlorourethane is suitably functionalised for further elaboration to give novel fused ring systems. This report describes the use of 2a to provide access to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ca983544cb1a517168748b725daafd1
https://doi.org/10.1039/a701762f
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8
Design and synthesis of novel muscarinic agonists containing the 1,2,4-triazine ring as an ester bioisostere
Autor: Julie Hawkins, Barry Sidney Orlek, Graham J. Riley, Emma J. Collings, Richard E. Faulkner, Frederick Cassidy, Michael S. G. Clark
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1411-1414
Replacement of the ester group in methyl quinuclidine-3-car☐ylate1 with a 1,2,4-triazine ring afforded the high affinity muscarinic partial agonist6a. Analogues7a,7b and7d which incorporate the 1-azabicyclo[2.2.1]heptane ring also display high affi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ea1c5a5b13daed15d24c4e60cfcbcab
https://doi.org/10.1016/s0960-894x(01)80503-5
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9
Bridged 1,2,5,6-tetrahydropyridine esters and oxime ethers related to arecoline are novel and potent muscarinic agonists
Autor: Frederick Cassidy, Richard E. Faulkner, Steven Mark Bromidge, Barry Sidney Orlek, Graham J. Riley, Michael S. G. Clark, Michael S. Hadley, Geoffrey Stemp
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1185-1190
Constraining the 1,2,5,6-tetrahydropyridine ring of arecoline 1a and the related muscarinic agonists 1b–e by replacing the N-methyl group by an ethano bridge between the nitrogen and the C5-position afforded compounds 2a–e . These compounds have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::216aad058f0c90c35f39eccebc1afa80
https://doi.org/10.1016/s0960-894x(01)80326-7
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10
1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists
Autor: Barry Sidney Orlek, Graham J. Riley, Richard E. Faulkner, Steven Mark Bromidge, Frank Brown, Michael S. G. Clark, Frederick Cassidy, Loudon Julia Mary, Steven Dabbs, Emma J. Collings
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:557-562
The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c , show favour
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d45b16026111b228491b57c2df1f13e
https://doi.org/10.1016/s0960-894x(01)80154-2
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