Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Barry S Cooperman"'
Publikováno v:
eLife, Vol 5 (2016)
The intergenic IRES of Cricket Paralysis Virus (CrPV-IRES) forms a tight complex with 80S ribosomes capable of initiating the cell-free synthesis of complete proteins in the absence of initiation factors. Such synthesis raises the question of what ef
Externí odkaz:
https://doaj.org/article/1dc196db97d14487906e155dfe99b076
Autor:
Marisa D Ruehle, Haibo Zhang, Ryan M Sheridan, Somdeb Mitra, Yuanwei Chen, Ruben L Gonzalez Jr, Barry S Cooperman, Jeffrey S Kieft
Publikováno v:
eLife, Vol 4 (2015)
Internal ribosome entry sites (IRESs) are powerful model systems to understand how the translation machinery can be manipulated by structured RNAs and for exploring inherent features of ribosome function. The intergenic region (IGR) IRESs from the Di
Externí odkaz:
https://doaj.org/article/427c93c8058e4b5fb4ed901849befe4e
Autor:
Benjamin Stevens, Chunlai Chen, Ian Farrell, Haibo Zhang, Jaskiran Kaur, Steven L Broitman, Zeev Smilansky, Barry S Cooperman, Yale E Goldman
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38344 (2012)
We present proof-of-concept in vitro results demonstrating the feasibility of using single molecule fluorescence resonance energy transfer (smFRET) measurements to distinguish, in real time, between individual ribosomes programmed with several differ
Externí odkaz:
https://doaj.org/article/f49773a75a654027816c8f47173d3619
Autor:
Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev, Yong Liu, Henrik Spåhr, Rolf Wibom, Ilian Atanassov, Minh Duc Nguyen, Barry S. Cooperman, Joanna Rorbach
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The mammalian mitochondrial genome contains two noncanonical stop codons, AGA and AGG. Here, the authors show that mtRF1, a mitochondrial protein of unknown function, triggers translation termination at AGA or AGG, placing mtRF1 among mitochondrial t
Externí odkaz:
https://doaj.org/article/30f7dc04bd874984a09d20e088a52037
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 242 (2023)
Premature termination codons (PTCs) account for ~12% of all human disease mutations. Translation readthrough-inducing drugs (TRIDs) are prominent among the several therapeutic approaches being used to overcome PTCs. Ataluren is the only TRID that has
Externí odkaz:
https://doaj.org/article/d59e387027ee41c0b0e2be0187997711
Autor:
Barry S. Cooperman
Publikováno v:
Molecules, Vol 26, Iss 5, p 1341 (2021)
The introduction of fluorophores into RNA for both in vitro and in cellulo studies of RNA function and cellular distribution is a subject of great current interest. Here I briefly review methods, some well-established and others newly developed, whic
Externí odkaz:
https://doaj.org/article/84a6eb24ddd94da7a7184570ea582c0f
Autor:
Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev, Yong Liu, Henrik Spåhr, Rolf Wibom, Ilian Atanassov, Minh Duc Nguyen, Barry S. Cooperman, Joanna Rorbach
Publikováno v:
Nature communications. 14(1)
The mitochondrial translation machinery highly diverged from its bacterial counterpart. This includes deviation from the universal genetic code, with AGA and AGG codons lacking cognate tRNAs in human mitochondria. The locations of these codons at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd04f0b03de56a4db4f453f458b9b8e9
https://pubmed.ncbi.nlm.nih.gov/36596788
https://pubmed.ncbi.nlm.nih.gov/36596788
Autor:
Shijie Huang, Arpan Bhattacharya, Mikel D. Ghelfi, Hong Li, Clark Fritsch, David M. Chenoweth, Yale E. Goldman, Barry S. Cooperman
Publikováno v:
Nature Communications. 13
Genetic diseases are often caused by nonsense mutations, but only one TRID (translation readthrough inducing drug), ataluren, has been approved for clinical use. Ataluren inhibits release factor complex (RFC) termination activity, while not affecting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b29c0f5e86698f2868294c8af85ac5
https://doi.org/10.1038/s41467-022-30080-6
https://doi.org/10.1038/s41467-022-30080-6
Autor:
Arpan Bhattacharya, Mikel D. Ghelfi, Xiaonan Cui, Clark Fritsch, Hong Li, Barry S. Cooperman, Yale E. Goldman
Publikováno v:
Biophysical Journal. 122:490a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c59422155ff3d69cedbfea8022541b9
https://doi.org/10.1016/j.bpj.2022.11.2618
https://doi.org/10.1016/j.bpj.2022.11.2618
Autor:
Saleem Y. Bhat, Mikel D. Ghelfi, Arpan Bhattacharya, Hong Li, Yale E. Goldman, Barry S. Cooperman
Publikováno v:
Biophysical Journal. 122:490a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9055f7d806fcc3865843ade227816e6a
https://doi.org/10.1016/j.bpj.2022.11.2619
https://doi.org/10.1016/j.bpj.2022.11.2619