Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Barry Ripley"'
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153399 (2016)
Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, progressive, motor neuron degenerative disease. Recent evidence indicates that inflammation is associated with many neurodegenerative diseases including ALS. Previously, abnormal levels of inflam
Externí odkaz:
https://doaj.org/article/00adda7bafee4112aa47aef4a19a8c9d
Autor:
Barry Ripley, David Millrine, Jaya Prakash Chalise, Kazuya Masuda, Kishan K. Nyati, Mohammad Mahabub-Uz Zaman, Wang Kai, Tadamitsu Kishimoto, Praveen K Dubey
Publikováno v:
International Immunology. 29:79-85
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the major causes of death worldwide due to acute inflammation in the lung. AT-rich interactive domain–containing 5a (Arid5a) is an RNA-binding protein involved in infl
Autor:
Tsukasa Mashima, Masato Katahira, Tadamitsu Kishimoto, Hamza Hanieh, Mitsuru Higa, Barry Ripley, Osamu Takeuchi, Kishan K. Nyati, Kazuya Masuda, Toru Okamoto, Praveen K Dubey, Daron M. Standley, Mohammad Mahabub-Uz Zaman, Yoshiharu Matsuura, Kazuo Yamashita
Publikováno v:
The Journal of Experimental Medicine
Masuda et al. show that Arid5a regulates the fate of naive CD4+ T cells to pro- or antiinflammatory T cells through selective stabilization of Stat3 mRNA under Th17-polarizing conditions.
Balance in signal transducer and activator of transcripti
Balance in signal transducer and activator of transcripti
Autor:
Mami Tei, Tadamitsu Kishimoto, Praveen K Dubey, Kishan K. Nyati, Yohannes Gemechu, Haruhiko Miyata, Barry Ripley, Taisuke Nakahama, David Millrine
Publikováno v:
International Immunology. 28:307-315
Thalidomide and its derivatives, collectively referred to as immunomodulatory drugs (IMiDs), are effective inhibitors of inflammation and are known to inhibit TLR-induced TNFα production. The identification of Cereblon as the receptor for these comp
Autor:
Mohammad Mahabub-Uz Zaman, Hamza Hanieh, Tadamitsu Kishimoto, Kazuya Masuda, Praveen K Dubey, Kai Wang, Jaya Prakash Chalise, Kishan K. Nyati, Mitsuru Higa, Barry Ripley
Adenine-thymine (AT)-rich interactive domain containing protein 5a (Arid5a) is an RNA-binding protein that has been shown to play an important immune regulatory function via the stabilization of IL-6 and STAT3 mRNA. However, the role of Arid5a in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc881d10d0d2eb937e35eb29740da080
https://europepmc.org/articles/PMC5068254/
https://europepmc.org/articles/PMC5068254/
The activation and differentiation of B cells are pivotal processes with major implications for host defense and the pathogenesis of immune-mediated diseases. During an immune response, B cells respond to cognate antigen by undergoing massive expansi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ab456a883a7f1acf35ca734d5c6437
https://doi.org/10.1016/b978-0-12-374279-7.09017-2
https://doi.org/10.1016/b978-0-12-374279-7.09017-2
Autor:
Yoshihito Souma, Yoshiki Sawa, Kota Iwahori, Barry Ripley, Kiyokazu Nakajima, Masaki Mori, Tsuyoshi Takahashi, Satoshi Serada, Yasuaki Miyazaki, Minoru Fujimoto, Toshirou Nishida, Yuichiro Doki, Tetsuji Naka
Publikováno v:
International Journal of Cancer. 131:1287-1296
Inflammation is a crucial driving force in the development of gastric cancers (GCs). Accordingly, persistent activation of STAT3, a transcription factor pivotal in regulating both inflammation and oncogenesis, is often detected in GC, although its me
Autor:
Ichino Chinen, Kishan K. Nyati, Akihiro Kimura, Tadamitsu Kishimoto, Hisako Kayama, Hiroshi Takemori, Ayako Kumagai, Soyoung Lee, Yoshiaki Fujii-Kuriyama, Kamal Chowdhury, Kiyoshi Takeda, David Millrine, Praveen K Dubey, Nam Trung Nguyen, Hamza Hanieh, Barry Ripley, Taisuke Nakahama
Publikováno v:
International Immunology
Aryl hydrocarbon receptor (Ahr), a transcription factor, plays a critical role in autoimmune inflammation of the intestine. In addition, microRNAs (miRNAs), small non-coding oligonucleotides, mediate pathogenesis of inflammatory bowel diseases (IBD).
Autor:
Hamza Hanieh, Kamal Chowdhury, Barry Ripley, So-Young Lee, Nam Trung Nguyen, Yukio Kawahara, Ichino Chinen, Kishan K. Nyati, David Millrine, Praveen K Dubey, Tadamitsu Kishimoto, Taisuke Nakahama
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (T H 17) and regulatory T cells. Although various transcription factors and cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fbca5d0e2407e5d4b0ca5fe4fe387e
https://europepmc.org/articles/PMC3718186/
https://europepmc.org/articles/PMC3718186/
Autor:
Tadamitsu Kishimoto, Osamu Takeuchi, Kazuya Masuda, Go Shioi, Barry Ripley, Takashi Mino, Hiroshi Kiyonari, Riko Nishimura
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(23)
Posttranscriptional regulation of IL-6 has been largely uncharacterized, with the exception of the ribonuclease Regnase-1, which prevents autoimmunity by destabilizing IL-6 mRNA. Here, we identified AT-rich interactive domain-containing protein 5A (A