Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Barry R, O'Keefe"'
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Kenya DeBarros, Mahfuz Khan, Morgan Coleman, Vincent C. Bond, Virginia Floyd, Erick Gbodossou, Amad Diop, Lauren R. H. Krumpe, Barry R. O’Keefe, Michael D. Powell
Publikováno v:
Viruses, Vol 16, Iss 9, p 1433 (2024)
MoMo30 is an antiviral protein isolated from aqueous extracts of Momordica balsamina L. (Senegalese bitter melon). Previously, we demonstrated MoMo30’s antiviral activity against HIV-1. Here, we explore whether MoMo30 has antiviral activity against
Externí odkaz:
https://doaj.org/article/6a84d8389db9421eb40115bf1581ae06
Autor:
Saidanxia Amuti, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Publikováno v:
Molecules, Vol 29, Iss 3, p 651 (2024)
Eight vilasinin-class limonoids, including the unusually chlorinated rubescins K–M (1–3), the 2,3-epoxylated rubescin N (4), and rubescins O–R (5–8), were newly isolated from Trichilia rubescens. The structures of the isolated compounds were
Externí odkaz:
https://doaj.org/article/73427dc785014662bb22d080535fb349
Autor:
Julia Krushkal, Simarjeet Negi, Laura M. Yee, Jason R. Evans, Tanja Grkovic, Alida Palmisano, Jianwen Fang, Hari Sankaran, Lisa M. McShane, Yingdong Zhao, Barry R. O'Keefe
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 381-406 (2021)
Natural products remain a significant source of anticancer chemotherapeutics. The search for targeted drugs for cancer treatment includes consideration of natural products, which may provide new opportunities for antitumor cytotoxicity as single agen
Externí odkaz:
https://doaj.org/article/4721b276f0d848a6b0da39b8d59f04a3
Autor:
Natalia Teleshova, Marla J Keller, José A Fernández Romero, Barbara A Friedland, George W Creasy, Marlena G Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N Fichorova, Tamara Kalir, Thomas M Zydowsky
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261775 (2022)
HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT's preclinical safety, lack of systemic absorption after vaginal administra
Externí odkaz:
https://doaj.org/article/71d1f80746cd4044a9318e97651b89ec
Autor:
Brice A. P. Wilson, Ning Li, Juliana A. Martinez Fiesco, Masoumeh Dalilian, Dongdong Wang, Emily A. Smith, Antony Wamiru, Rohan Shah, Ekaterina I. Goncharova, John A. Beutler, Tanja Grkovic, Ping Zhang, Barry R. O’Keefe
Publikováno v:
ACS Pharmacology & Translational Science. 6:633-650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::304996b7e53aa21cbce68dfb3e0ac41b
https://doi.org/10.1021/acsptsci.3c00010
https://doi.org/10.1021/acsptsci.3c00010
Autor:
Jason R. Evans, Rhone K. Akee, Shaurya Chanana, Grant D. McConachie, Christopher C. Thornburg, Tanja Grkovic, Barry R. O’Keefe
Publikováno v:
ACS Omega. 8:9250-9256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb752bdd174dd369b0183be521102d4
https://doi.org/10.1021/acsomega.2c07416
https://doi.org/10.1021/acsomega.2c07416
Autor:
Quan T. Khong, Donghao Li, Brice A. P. Wilson, Kalina Ranguelova, Masoumeh Dalilian, Emily A. Smith, Antony Wamiru, Ekaterina I. Goncharova, Tanja Grkovic, Donna Voeller, Stanley Lipkowitz, Martin J. Schnermann, Barry R. O’Keefe, Lin Du
Publikováno v:
Organic Letters. 24:9468-9472
A new dimeric alkaloid plakoramine A [(±)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478b15513a04cbba195f339a481dd78f
https://doi.org/10.1021/acs.orglett.2c03922
https://doi.org/10.1021/acs.orglett.2c03922
Autor:
Punya Shrivastava-Ranjan, Michael K. Lo, Payel Chatterjee, Mike Flint, Stuart T. Nichol, Joel M. Montgomery, Barry R. O'Keefe, Christina F. Spiropoulou
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics are approved for use against these infections. Griffithsin (GRFT) is a high-mannose oligosac
Externí odkaz:
https://doaj.org/article/7f404e9381c2404eba7fb33c6ff7c192
Autor:
Nina Derby, Manjari Lal, Meropi Aravantinou, Larisa Kizima, Patrick Barnable, Aixa Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R O’Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José A. Fernández-Romero, Thomas M. Zydowsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving
Externí odkaz:
https://doaj.org/article/8d4f42eeb266482fa22316c03e392e44