Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Barry Patrick Hart"'
Autor:
Huiyong Hu, Barry Patrick Hart, Roopa Rai, Michael J. Green, Ravi Rajagopalan, Yu M. Xia, Joseph D. Ho, John R. Somoza, Isabelle Lehoux, Dange Vijay Kumar, Jennifer Riggs, Ken A. Brameld, James W. Janc, Tony Ton, Wendy B. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:300-304
The discovery and optimization of a novel class of quinolone small-molecules that inhibit NS5B polymerase, a key enzyme of the HCV viral life-cycle, is described. Our research led to the replacement of a hydrolytically labile ester functionality with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3593c853fb618014eb009af3250b00b8
https://doi.org/10.1016/j.bmcl.2011.11.013
https://doi.org/10.1016/j.bmcl.2011.11.013
Autor:
Glenn Mcenroe, Wolfgang Wick, Alison Murphy, Martin Uhl, Ann M. Kapoun, Andrew Lam, Heather K. Webb, Thomas-Toan Tran, Sundeep Dugar, Jonathan Axon, Steffen Aulwurm, Barry Patrick Hart, Linda S. Higgins, Jing Ying Ma, Venkataraman Sriram, Lisa Janssen, Sarvajit Chakravarty, Michael Weller, Darin E. Kizer, Andrew A. Protter, Darren H. Wong, Irene Kerr
Publikováno v:
Neuro-Oncology. 9:259-270
Transforming growth factor-beta (TGF-beta) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling TGF-beta activity in gliomas is to disrupt the signaling cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdd7196e1e669e29fe4b1c79a10fd8a
https://doi.org/10.1215/15228517-2007-010
https://doi.org/10.1215/15228517-2007-010