Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Barry P Sleckman"'
Autor:
Faith C Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P Sleckman, Jessica K Tyler
Publikováno v:
eLife, Vol 11 (2022)
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G2 phases of the cell cycle partly due to 53BP1 antagonizing DNA end resection in G1 phase and non-cycling quiescent (G0) cells where DSBs are predominately rep
Externí odkaz:
https://doaj.org/article/20fdda038d0c46f1ba37279b0a8d1e09
Autor:
Bo-Ruei Chen, Yinan Wang, Anthony Tubbs, Dali Zong, Faith C Fowler, Nicholas Zolnerowich, Wei Wu, Amelia Bennett, Chun-Chin Chen, Wendy Feng, Andre Nussenzweig, Jessica K Tyler, Barry P Sleckman
Publikováno v:
eLife, Vol 10 (2021)
DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G2- phases of the cell cycle in part due to 53BP1 antagonizing DNA end resection in G1-phase and non-cycling quiescent (G0) cells. Here, w
Externí odkaz:
https://doaj.org/article/0d399988ea5d4729923352965a4c0d86
Autor:
Abigail J Morales, Javier A Carrero, Putzer J Hung, Anthony T Tubbs, Jared M Andrews, Brian T Edelson, Boris Calderon, Cynthia L Innes, Richard S Paules, Jacqueline E Payton, Barry P Sleckman
Publikováno v:
eLife, Vol 6 (2017)
Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded
Externí odkaz:
https://doaj.org/article/8b32ac03f3394b97a090866be11137aa
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21627 (2011)
Non-productive antigen receptor genes with frame shifts generated during the assembly of these genes are found in many mature lymphocytes. Transcripts from these genes have premature termination codons (PTCs) and could encode truncated proteins if th
Externí odkaz:
https://doaj.org/article/e2ff772871d342bf9ea8f042e8b4cf46
Autor:
Brandon J. Metge, Heba A. Alsheikh, Dongquan Chen, Amr R. Elhamamsy, Dominique C. Hinshaw, Bo-Ruei Chen, Barry P. Sleckman, Rajeev S. Samant, Lalita A. Shevde
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-15 (2023)
Abstract Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by nucleomorphometric alterations and increased nucleolar counts. Ribosome biogenesi
Externí odkaz:
https://doaj.org/article/b2323fac90854d5292281b8d83c481fc
Autor:
Mona N. Fouad, Daniel I. Chu, Barry P. Sleckman, Haller J. Smith, Thomas N. Wang, J. Bart Rose, Jeremie M. Lever, A. Irfan, Sushanth Reddy
Publikováno v:
The American Journal of Surgery. 223:722-728
Introduction As healthcare systems are adapting due to COVID-19, there has been an increased need for telehealth in the outpatient setting. Not all patients have been comfortable with this transition. We sought to determine the relationship between h
Autor:
Eddy S. Yang, Tim M. Townes, Jianmei W. Leavenworth, Narendra Wajapeyee, Ling Zeng, Zechen Chong, Chao Li, Zhuo Zhang, Barry P. Sleckman, Mao Li, Deborah L. Della Manna, Chuan Xing, Peng Xu, Yu Chen, William J. Britt, Sadashib Ghosh, Lin Luo
Publikováno v:
Nature Cancer. 2:1018-1038
Expanding the utility of immune-based cancer treatments is a clinical challenge due to tumor-intrinsic factors that suppress the immune response. Here we report the identification of tumoral ring finger protein 2 (RNF2), the core subunit of polycomb
Autor:
Hongzhi Li, Chen Wang, André Nussenzweig, Raphael Souza Pavani, Nicholas Zolnerowich, Jacob Paiano, Li Zheng, Wei Wu, Barry P. Sleckman, Binghui Shen, Bo-Ruei Chen
Publikováno v:
Genes & Development. 35:1356-1367
Double-strand break (DSB) repair choice is greatly influenced by the initial processing of DNA ends. 53BP1 limits the formation of recombinogenic single-strand DNA (ssDNA) in BRCA1-deficient cells, leading to defects in homologous recombination (HR).
Autor:
Bo-Ruei Chen, Barry P. Sleckman
Publikováno v:
Frontiers in Cell and Developmental Biology. 10
DNA double-strand breaks (DSBs) constantly arise upon exposure to genotoxic agents and during physiological processes. The timely repair of DSBs is important for not only the completion of the cellular functions involving DSBs as intermediates, but a
Autor:
Mona N. Fouad, Thomas N. Wang, J. B. Rose, Barry P. Sleckman, Jeremie M. Lever, D. I. Chu, A. Irfan, Sushanth Reddy
Publikováno v:
Journal of the National Comprehensive Cancer Network. 19:HSR21-059
Background: The COVID-19 pandemic has led to the rapid expansion of telehealth use. Telehealth has the potential to improve access for underserved populations who live far distances from well-equipped medical centers. This healthcare modality will li