Exploiting a Rose Bengal-bearing, oxygen-producing nanoparticle for SDT and associated immune-mediated therapeutic effects in the treatment of pancreatic cancer

Autor: John F. Callan, Barry O'Hagan, Nikolitsa Nomikou, Paul J Kelly, Bridgeen Callan, Simon L Porter, Eva McMullin, Dean Nicholas, Declan O'Rourke, Anthony P. McHale, Sian Farrell, Tierna Gillan, Heather Nesbitt, Keith Thomas, Keirin Logan

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 163:49-59

Sonodynamic therapy (SDT) is an emerging stimulus-responsive approach for the targeted treatment of solid tumours. However, its ability to generate stimulus-responsive cytotoxic reactive oxygen species (ROS), is compromised by tumour hypoxia. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec05b0a0b74b3c65d17998bf0ae7a266
https://doi.org/10.1016/j.ejpb.2021.03.005

A rapid antimicrobial photodynamic water treatment strategy utilizing a xanthene dye with subsequent removal by Goethite Nanoparticles

Autor: Elaine Meade, John F. Callan, Barry O'Hagan, Colin Fowley, Mary Garvey, Sean Doyle, Jinhui Gao

Publikováno v: Chemosphere. 280

Although widely accepted as a water sterilisation technique, chlorination results in the production of potentially harmful by-products, mainly Trihalomethanes. Furthermore, the chlorination process requires specialised infrastructure, management and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c326508bdb59bfe75e256e30de76c6
https://pubmed.ncbi.nlm.nih.gov/33971423

Microscopic Investigation of the Combined Use of Antibiotics and Biosurfactants on Methicillin Resistant Staphylococcus aureus

Autor: Barry O'Hagan, Patrick Lemoine, James G Dooley, Patrick Naughton, Alistair B J Simpson, Abulaziz Juma, Jason Murray, Ibrahim M. Banat

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

One current strategy to deal with the serious issue of antibiotic resistance is to use biosurfactants, weak antimicrobials in their own right, with antibiotics in order to extend the efficacy of antibiotics. Although an adjuvant effect has been obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a4016d72055266e696834315575fb5
https://www.frontiersin.org/article/10.3389/fmicb.2020.01477/full

A novel approach for dynamic in-situ surface characterisation of milk protein concentrate hydration and reconstitution using an environmental scanning electron microscope

Autor: Valeria L. Cenini, David J. McSweeney, George McKerr, Lucy Gallagher, Barry O'Hagan, Mark A.E. Auty, Noel A. McCarthy

Publikováno v: Food Hydrocolloids. 108:105881

Composition and relative humidity (RH) can have a profound impact on the physical (flowability, stickiness) and functional (reconstitution) properties of milk powder (MP) and therefore its quality, storage stability and shelf-life. Conventional micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f9ad781ce1b6762e53729df07e9f320
https://doi.org/10.1016/j.foodhyd.2020.105881

Inactivation of the dnaK gene in Clostridium difficile 630 Δerm yields a temperature-sensitive phenotype and increases biofilm-forming ability

Autor: Barry O'Hagan, John T. Heap, Geoff McMullan, Deborah Smyth, Nigel P. Minton, Shailesh Jain, Nigel G. Ternan

Publikováno v: Jain, S, Smyth, D, O'Hagan, B M G, Heap, J T, McMullan, G, Minton, N P & Ternan, N G 2017, ' Inactivation of the dnaK gene in Clostridium difficile 630 Δerm yields a temperature-sensitive phenotype and increases biofilm-forming ability ', Scientific Reports, vol. 7, no. 1, 17522, pp. 1-13 . https://doi.org/10.1038/s41598-017-17583-9, https://doi.org/10.1038/s41598-017-17583-9
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Clostridium difficile infection is a growing problem in healthcare settings worldwide and results in a considerable socioeconomic impact. New hypervirulent strains and acquisition of antibiotic resistance exacerbates pathogenesis; however, the surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b566c6794150b2f007b234b54766a
https://pure.qub.ac.uk/en/publications/inactivation-of-the-dnak-gene-in-clostridium-difficile-630-erm-yields-a-temperaturesensitive-phenotype-and-increases-biofilmforming-ability(b128648f-6459-4870-939c-51a4db429fd2).html