Mammalian Tolloid-like 1 Binds Procollagen C-proteinase Enhancer Protein 1 and Differs from Bone Morphogenetic Protein 1 in the Functional Roles of Homologous Protein Domains

Autor: Barry M. Steiglitz, Gaoxiang Ge, Daniel S. Greenspan, Yue Zhang

Publikováno v: Journal of Biological Chemistry. 281:10786-10798

Bone morphogenetic protein 1 (BMP1) is the prototype of a subgroup of metalloproteinases with manifold roles in morphogenesis. Four mammalian subgroup members exist, including BMP1 and mammalian Tolloid-like 1 (mTLL1). Subgroup members have a conserv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1515ca361fa34fc8f43bbc806f2b9601
https://doi.org/10.1074/jbc.m511111200

Transforming Growth Factor-β Induces Secretion of Activated ADAMTS-2

Autor: Wei-Man Wang, Mitchell C. Brenner, M. Leah Allen, Barry M. Steiglitz, Ian C. Scott, Kazuhiko Takahara, Seungbok Lee, Carter C. Lebares, Daniel S. Greenspan

Publikováno v: Journal of Biological Chemistry. 278:19549-19557

The metalloproteinase ADAMTS-2 has procollagen I N-proteinase activity capable of cleaving procollagens I and II N-propeptides in vitro, whereas mutations in the ADAMTS-2 gene in dermatosparaxis and Ehlers-Danlos syndrome VIIC show this enzyme to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92033b2db1b34d047790a623aeedfd3e
https://doi.org/10.1074/jbc.m300767200

Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain

Autor: Timothy G. Clark, Daniel S. Greenspan, Barry M. Steiglitz, Ian C. Scott, William N. Pappano

Publikováno v: Developmental Dynamics. 217:449-456

Chordin is an antagonist of TGFβ-like bone morphogenetic proteins (BMPs) that plays roles in dorsoventral axis formation and in induction, maintenance and/or differentiation of neural tissue in early vertebrate embryogenesis. In contrast, little is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::783c433c442498a5b760769d8609ec8d
https://doi.org/10.1002/(sici)1097-0177(200004)217:4<449::aid-dvdy12>3.0.co

Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1

Autor: Melvin Ayala, Daniel S. Greenspan, Karthikeyan Narayanan, Barry M. Steiglitz, Anne George

Publikováno v: The Journal of biological chemistry. 279(2)

Bone morphogenetic protein-1 (BMP-1)/Tolloid-like metalloproteinases play key roles in formation of mammalian extracellular matrix (ECM), through the biosynthetic conversion of precursor proteins into their mature functional forms. These proteinases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc847622bd1c0e16a4d8568fdb3888a
https://pubmed.ncbi.nlm.nih.gov/14578349

Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein

Autor: Christine Ebel, Denise Eichenberger, Gilbert Deléage, Sylvie Ricard-Blum, Maxim V. Petoukhov, Christophe Geourjon, Dmitri I. Svergun, Barry M. Steiglitz, Simonetta Bernocco, Florence Ruggiero, David J.S. Hulmes, Daniel S. Greenspan, Bernard Font

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (9), pp.7199-205. ⟨10.1074/jbc.M210857200⟩
Journal of Biological Chemistry, 2003, 278 (9), pp.7199-205. ⟨10.1074/jbc.M210857200⟩

International audience; Procollagen C-proteinase enhancer (PCPE) is an extracellular matrix glycoprotein that can stimulate the action of tolloid metalloproteinases, such as bone morphogenetic protein-1, on a procollagen substrate, by up to 20-fold.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c5a11fef80792ae98b9380a5fb95a2
https://pubmed.ncbi.nlm.nih.gov/12486138