Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Barry M. Forman"'
Autor:
Guorong Xu, Hai Li, Lu-xing Pan, Quan Shang, Akira Honda, M. Ananthanarayanan, Sandra K. Erickson, Benjamin L. Shneider, Sarah Shefer, Jaya Bollineni, Barry M. Forman, Yasushi Matsuzaki, Frederick J. Suchy, G. Stephen Tint, Gerald Salen
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 10, Pp 1956-1962 (2003)
We investigated how cholesterol feeding regulates cholesterol 7α-hydroxylase (CYP7A1) via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor α (LXRα) in New Zealand white rabbits. After 1 day of 2% cholesterol feeding, when the
Externí odkaz:
https://doaj.org/article/837a8425f81549c1ab7fa240a891686f
Autor:
Guorong Xu, Lu-xing Pan, Sandra K. Erickson, Barry M. Forman, Benjamin L. Shneider, M. Ananthanarayanan, Xiaogui Li, Sarah Shefer, N. Balasubramanian, Lin Ma, Hitoshi Asaoka, Steven R. Lear, Lien B. Nguyen, Isabelle Dussault, Frederick J. Suchy, G. Stephen Tint, Gerald Salen
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 1, Pp 45-50 (2002)
We investigated the role of the orphan nuclear receptor farnesoid X receptor (FXR) in the regulation of cholesterol 7α-hydroxylase (CYP7A1), using an in vivo rabbit model, in which the bile acid pool, which includes high affinity ligands for FXR, wa
Externí odkaz:
https://doaj.org/article/cfdfe43fe9f444c8937c82ae74f94e34
Nonalcoholic fatty liver disease (NAFLD) is a severe liver disease causing serious liver complications, including nonalcoholic steatohepatitis (NASH). Nuclear receptor PPARα (peroxisome proliferator-activated receptor α) has drawn special attention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6133e25c4f6e5ae72365cfc4bed16991
https://resolver.caltech.edu/CaltechAUTHORS:20210507-140316316
https://resolver.caltech.edu/CaltechAUTHORS:20210507-140316316
Autor:
Xiaohui Yuan, Tuong Chi Ta, Min Lin, Jane R Evans, Yinchen Dong, Eugene Bolotin, Mark A Sherman, Barry M Forman, Frances M Sladek
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5609 (2009)
Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches. As a r
Externí odkaz:
https://doaj.org/article/85c48b9141a64c0e9c24ebf18328d32c
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1585-1599
Estrogen-related receptors (ERRs, α, β, and γ) are orphan nuclear receptors most closely related in sequence to estrogen receptors (ERα and ERβ). Much attention has been paid recently to the functions of ERRs for their potential roles as new the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ce1bf58e9ba2bea7e71b1ee70677b6
https://doi.org/10.1016/j.bmc.2017.01.019
https://doi.org/10.1016/j.bmc.2017.01.019
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:4266-4278
FXR (farnesoid X receptor, NRIH4), a nuclear receptor, plays a major role in the control of cholesterol metabolism. FXR ligands have been investigated in preclinical studies for targeted therapy against metabolic diseases, but have shown limitations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb79a0169800c3cf1a681ca1e0a3e1c4
https://doi.org/10.1016/j.bmc.2013.04.069
https://doi.org/10.1016/j.bmc.2013.04.069
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 345:438-445
The MDR1 gene encodes P-glycoprotein, a transmembrane drug efflux transporter that confers multidrug resistance in cancer cells and affects drug pharmacokinetics by virtue of its expression in the liver, kidney, and colon. Nuclear receptors human ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24e47e2e7a0ee9d9f418e77e5641827
https://doi.org/10.1124/jpet.113.203562
https://doi.org/10.1124/jpet.113.203562
Publikováno v:
Bioorganicmedicinal chemistry. 24(18)
Metabolic disorders such as diabetes are known risk factors for developing cholesterol gallstone disease (CGD). Cholesterol gallstone disease is one of the most prevalent digestive diseases, leading to considerable financial and social burden worldwi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b4f8549771726293e5b49ec8185bca
https://pubmed.ncbi.nlm.nih.gov/27372840
https://pubmed.ncbi.nlm.nih.gov/27372840
Publikováno v:
Steroids. 77:1335-1338
The active, potent, and selective Farnesoid X Receptor (FXR) agonist 6α-ethylchenodeoxycholic acid (6ECDCA) has been synthesized in improved yield compared to the published methodologies. The synthesis employed selective oxidation of one of the two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73716d2171ace0a82d8b1923ef37001f
https://doi.org/10.1016/j.steroids.2012.09.002
https://doi.org/10.1016/j.steroids.2012.09.002
Publikováno v:
Molecular Endocrinology. 26:27-36
Acute lung injury and its more severe form, acute respiratory distress syndrome, are characterized by an acute inflammatory response in the airspaces and lung parenchyma. The nuclear receptor farnesoid X receptor (FXR) is expressed in pulmonary arter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6d36e1d3ba6808d8168aee7402577d
https://doi.org/10.1210/me.2011-0042
https://doi.org/10.1210/me.2011-0042