Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Barry L. Fanburg"'
Autor:
Brianna F. Moon, Iris Y. Zhou, Yingying Ning, Yin‐Ching I. Chen, Mariane Le Fur, Sergey Shuvaev, Eman A. Akam, Hua Ma, Cesar Molinos Solsona, Jonah Weigand‐Whittier, Nicholas Rotile, Lida P. Hariri, Matthew Drummond, Avery T. Boice, Samantha E. Zygmont, Yamini Sharma, Rod R. Warburton, Gregory L. Martin, Robert M. Blanton, Barry L. Fanburg, Nicholas S. Hill, Peter Caravan, Krishna C. Penumatsa
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background Aging‐associated left ventricular dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right ventricular failure. At the time of diagnosis, cardiac function has declined, and cardiopulmonar
Externí odkaz:
https://doaj.org/article/fa3b4d084c534778b2beccd7d0657d41
Autor:
Krishna C. Penumatsa, Yamini Sharma, Rod R. Warburton, Adit Singhal, Deniz Toksoz, Chinmayee D. Bhedi, Guanming Qi, Ioana R. Preston, Christina Anderlind, Nicholas S. Hill, Barry L. Fanburg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pulmonary hypertension (PH) pathogenesis is driven by inflammatory and metabolic derangements as well as glycolytic reprogramming. Induction of both interleukin 6 (IL6) and transglutaminase 2 (TG2) expression participates in human and experimental ca
Externí odkaz:
https://doaj.org/article/381c17b270eb4d1c8a45c65eadd5697c
Autor:
Krishna C. Penumatsa, Ines Falcão-Pires, Sara Leite, Adelino Leite-Moreira, Chinmayee D. Bhedi, Sabina Nasirova, Jing Ma, Roy L. Sutliff, Barry L. Fanburg
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Diastolic dysfunction of the heart and decreased compliance of the vasculature and lungs (i.e., increased organ tissue stiffness) are known features of obesity and the metabolic syndrome. Similarly, cardiac diastolic dysfunction is associated with ag
Externí odkaz:
https://doaj.org/article/c493d84ab73b45c896c1a9b34ef67050
Autor:
Deniz Toksoz, David J. Kwiatkowski, Barry L. Fanburg, Yingling Liu, Amy J. Malhowski, Geraldine A. Finlay
Supplementary Figure 1 from Selective Inhibition of Growth of Tuberous Sclerosis Complex 2–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c118f0df7d182b384654647cf6a0a0
https://doi.org/10.1158/0008-5472.22370594.v1
https://doi.org/10.1158/0008-5472.22370594.v1
Autor:
Deniz Toksoz, David J. Kwiatkowski, Barry L. Fanburg, Yingling Liu, Amy J. Malhowski, Geraldine A. Finlay
Inactivating mutations in the tuberous sclerosis complex 2 (TSC2) gene, which encodes tuberin, result in the development of TSC and lymphangioleiomyomatosis (LAM). The tumor suppressor effect of tuberin lies in its GTPase-activating protein activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8072cec3f1bab399e01490310c3d0d
https://doi.org/10.1158/0008-5472.c.6496451
https://doi.org/10.1158/0008-5472.c.6496451
Autor:
Krishna C. Penumatsa, Adit A. Singhal, Rod R. Warburton, Michael D. Bear, Chinmayee D. Bhedi, Sabina Nasirova, Jamie L. Wilson, Guanming Qi, Ioana R. Preston, Nicholas S. Hill, Barry L. Fanburg, Young-Bum Kim, Deniz Toksoz
Publikováno v:
Biochem Biophys Res Commun
Rho kinase (ROCK) is implicated in the development of pulmonary arterial hypertension (PAH) in which abnormal pulmonary vascular smooth muscle (VSM) contractility and remodeling lead to right heart failure. Pharmacologic ROCK inhibitors block experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bc95e7ea01d24c852bc7b781c67116
https://europepmc.org/articles/PMC9047112/
https://europepmc.org/articles/PMC9047112/
Autor:
Barry L. Fanburg, Navin K. Kapur, Krishna Penumatsa, Deniz Toksoz, Ioana R. Preston, Rod R. Warburton, Chinmayee D. Bhedi, Jonas B. Galper, Sabina Nasirova, Nicholas S. Hill, Kevin J. Morine
Publikováno v:
FASEB J
The pathophysiology of pulmonary hypertension (PH) and heart failure (HF) includes fibrogenic remodeling associated with loss of pulmonary arterial (PA) and cardiac compliance. We and others have previously identified that transglutaminase 2 (TG2) as
Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension
Autor:
Chaitan Khosla, Barry L. Fanburg, Krishna Penumatsa, Deniz Toksoz, Navin K. Kapur, Mousa Kharnaf, Nicholas S. Hill, Ioana R. Preston, Rod R. Warburton
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L752-L762
Tissue matrix remodeling and fibrosis leading to loss of pulmonary arterial and right ventricular compliance are important features of both experimental and clinical pulmonary hypertension (PH). We have previously reported that transglutaminase 2 (TG
Publikováno v:
The Journal of physiology. 597(4)
Autor:
Ioana R. Preston, Michael D. Bear, Shereen Abualkhair, Maher A. Ghamloush, Nicholas S. Hill, Barry L. Fanburg, Usamah S. Kayyali, Deniz Toksoz, Tiegang Liu
Publikováno v:
Journal of Cellular Physiology. 231:934-943
The ubiquitous α-catulin acts as a scaffold for distinct signalosomes including RhoA/ROCK; however, its function is not well understood. While α-catulin has homology to the cytoskeletal linkers α-catenin and vinculin, it appears to be functionally