Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Barry J. Thompson"'
Autor:
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and infla
Externí odkaz:
https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c67
Autor:
Mario Aguilar-Aragon, Ahmed Elbediwy, Valentina Foglizzo, Georgina C. Fletcher, Vivian S.W. Li, Barry J. Thompson
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1639-1646 (2018)
Summary: Epithelial cells are polarized along their apical-basal axis by the action of the small GTPase Cdc42, which is known to activate the aPKC kinase at the apical domain. However, loss of aPKC kinase activity was reported to have only mild effec
Externí odkaz:
https://doaj.org/article/eaf4599611d44c6c98975889ba8b5dd6
Autor:
Clara Sidor, Nerea Borreguero-Munoz, Georgina C Fletcher, Ahmed Elbediwy, Oriane Guillermin, Barry J Thompson
Publikováno v:
eLife, Vol 8 (2019)
Mask family proteins were discovered in Drosophila to promote the activity of the transcriptional coactivator Yorkie (Yki), the sole fly homolog of mammalian YAP (YAP1) and TAZ (WWTR1). The molecular function of Mask, or its mammalian homologs Mask1
Externí odkaz:
https://doaj.org/article/c164dd5a41d141f28cc8676d26edc45c
Autor:
Teresa T Bonello, Danfeng Cai, Georgina C Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange, Zhe Liu, Jennifer Lippincott‐Schwartz, Jennifer M Kavran, Barry J Thompson
The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed60927d663b1406c463ef1b77686d22
Autor:
Marie-Charlotte Dolmart, John-Paul Kilday, Noreen Eder, Suzanne Claxton, Ambrosius P. Snijders, Junhao Mao, Helen R. Flynn, Torsten Pietsch, Felipe Andreiuolo, Stuart Horswell, Sila K. Ultanir, Federico Roncaroli, Lucy M. Collinson, André T. Lopes, Barry J. Thompson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Eder, N, Roncaroli, F, Dolmart, M-C, Horswell, S, Andreiuolo, F, Flynn, H R, Lopes, A T, Claxton, S, Kilday, J-P, Collinson, L, Mao, J-H, Pietsch, T, Thompson, B, Snijders, A P & Ultanir, S K 2020, ' YAP1/TAZ drives ependymoma-like tumour formation in mice ', Nature Communications, vol. 11, no. 1, pp. 2380 . https://doi.org/10.1038/s41467-020-16167-y
Nature Communications
Eder, N, Roncaroli, F, Dolmart, M-C, Horswell, S, Andreiuolo, F, Flynn, H R, Lopes, A T, Claxton, S, Kilday, J-P, Collinson, L, Mao, J-H, Pietsch, T, Thompson, B, Snijders, A P & Ultanir, S K 2020, ' YAP1/TAZ drives ependymoma-like tumour formation in mice ', Nature Communications, vol. 11, no. 1, pp. 2380 . https://doi.org/10.1038/s41467-020-16167-y
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient
Autor:
Rachel A. Ridgway, Barry J. Thompson, Anna Kucharska, Owen J. Sansom, Julia B. Cordero, Nikolaos Angelis, Clara M. Sidor, Pedro Antas, Vivian S. W. Li, Melissa R Rose, Oriane Guillermin, Anna Baulies
Publikováno v:
The EMBO Journal
Wnt signalling induces a gradient of stem/progenitor cell proliferation along the crypt‐villus axis of the intestine, which becomes expanded during intestinal regeneration or tumour formation. The YAP transcriptional co‐activator is known to be r
Autor:
Barry J. Thompson
Publikováno v:
The FEBS journal. 289(3)
The Par-3/Baz family of polarity determinants is highly conserved across metazoans and includes C. elegans PAR-3, Drosophila Bazooka (Baz), human Par-3 (PARD3), and human Par-3-like (PARD3B). The C. elegans PAR-3 protein localises to the anterior pol