Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Barry J. Hoffer"'
Autor:
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial
Externí odkaz:
https://doaj.org/article/42e9f0f96ce54c0abdd8d29f68afa314
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106563- (2024)
Externí odkaz:
https://doaj.org/article/4a8fdaad6d87422b91427c0a069d7f0b
Autor:
Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)
Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved dr
Externí odkaz:
https://doaj.org/article/7c5613a4803945af9101f28f707d2991
Autor:
Elliot J. Glotfelty, Luis B. Tovar-y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson, Nigel H. Greig
Publikováno v:
Cells, Vol 12, Iss 10, p 1367 (2023)
Neuroinflammation is a unifying factor among all acute central nervous system (CNS) injuries and chronic neurodegenerative disorders. Here, we used immortalized microglial (IMG) cells and primary microglia (PMg) to understand the roles of the GTPase
Externí odkaz:
https://doaj.org/article/92ddbaddb19c409ea44ce0d43af5de5a
Autor:
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Kuan-Yin Tseng
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4687 (2023)
To determine the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors, and neurochemistry in a progressive Parkinson’s disease (PD) MitoPark mouse model. To investigate the effects of PT320 on the manifestation of dyskinesia in L-DOPA-primed mi
Externí odkaz:
https://doaj.org/article/59fb7eaa86e745d292c83b94c18c7430
Autor:
Man-Hau Ho, Chia-Hung Yen, Tsung-Hsun Hsieh, Tzu-Jen Kao, Jing-Yuan Chiu, Yung-Hsiao Chiang, Barry J. Hoffer, Wen-Chang Chang, Szu-Yi Chou
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102067- (2021)
Traumatic brain injury (TBI) is a prevalent head injury worldwide which increases the risk of neurodegenerative diseases. Increased reactive oxygen species (ROS) and inflammatory chemokines after TBI induces secondary effects which damage neurons. Ta
Externí odkaz:
https://doaj.org/article/91593b3bc5904dee8b942b464cbec397
Autor:
Shih Chang Hsueh, Michael T. Scerba, David Tweedie, Daniela Lecca, Dong Seok Kim, Abdul Mannan Baig, Yu Kyung Kim, Inho Hwang, Sun Kim, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2449 (2022)
Traumatic brain injury (TBI) is a major risk factor for several neurodegenerative disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Neuroinflammation is a cause of later secondary cell death following TBI, has the potent
Externí odkaz:
https://doaj.org/article/7363abdad1cd4e2f96aeea1e980c087f
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 439-453 (2019)
Traumatic brain injury (TBI) is a neurodegenerative disorder for which no effective pharmacological treatment is available. Glucagon-like peptide 1 (GLP-1) analogues such as Exenatide have previously demonstrated neurotrophic and neuroprotective effe
Externí odkaz:
https://doaj.org/article/ed22acdb854b481d8687b470984eeda5
Autor:
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 950 (2022)
(1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tole
Externí odkaz:
https://doaj.org/article/abe37d4afed640b4839048006b4ded35
Autor:
Michael K. Ghiam, Shrey D. Patel, Alan Hoffer, Warren R. Selman, Barry J. Hoffer, Michael E. Hoffer
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Traumatic brain injury (TBI) is the most common cause of morbidity among trauma patients; however, an effective pharmacological treatment has not yet been approved. Individuals with TBI are at greater risk of developing neurological illnesses such as
Externí odkaz:
https://doaj.org/article/1b5fb75b58e240389cba482d54dc82c4