Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Barry J. Cusack"'
Publikováno v:
Investigational new drugs. 34(6)
Purpose A novel doxorubicin (DOX) analog, 13-deoxy, 5-iminodoxorubicin (DIDOX), was synthesized to prevent quinone redox cycling and alcohol metabolite formation, two prevailing hypotheses of anthracycline cardiotoxicity. The chronic cardiotoxicity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abb5717edfa4d44778d120f4c6ca9c1
https://pubmed.ncbi.nlm.nih.gov/27581956
https://pubmed.ncbi.nlm.nih.gov/27581956
Autor:
Henry A. Charlier, Andrew M. Slupe, Berea Williams, Barry J. Cusack, Jeffrey M. Peloquin, Herve A. Gambliel, Don L. Warner, Amanda J. Bruesch, Chad Bjorklund, Laura M. Lee, Susan E. Shadle, Toby Primbs, Corianton L. Larson, Richard D. Olson
Publikováno v:
Cardiovascular Toxicology. 5:365-376
Carbonyl reductase (CR) catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of several carbonyls. Anthracyclines used to treat cancer are reduced by CR at the C13 carbonyl and the resulting metabolites are implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a78e77198e19222d6a29c99ab8b1a5
https://doi.org/10.1385/ct:5:4:365
https://doi.org/10.1385/ct:5:4:365
Autor:
Richard D. Olson, Susan E. Shadle, Barry J. Cusack, Herve A. Gambliel, Robert E. Vestal, Henry A. Charlier
Publikováno v:
Cardiovascular Toxicology. 5:269-284
Utilizing a model of chronic doxorubicin cardiomyopathy, this study examines the relationship between changes in expression and function of calcium handling proteins and contractile dysfunction. A possible mechanism to account for this relationship i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d2e68826ec0f3ffdad3741fac25cbc
https://doi.org/10.1385/ct:5:3:269
https://doi.org/10.1385/ct:5:3:269
Publikováno v:
Biomedicine & Pharmacotherapy. 56:283-288
Approximately 30% of women afflicted with migraine have menstrually associated attacks. These migraines are often refractory to treatment. Evidence suggests estrogen and progestin fluctuations may influence menstrual migraine. Phytoestrogens have dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2f5df0c5129b4a95d9541411764fcb
https://doi.org/10.1016/s0753-3322(02)00181-6
https://doi.org/10.1016/s0753-3322(02)00181-6
Autor:
Renke Dai, Yongsheng Ma, Michael J Spence, Barry J. Cusack, Robert E. Vestal, Fred K. Friedman, Nicholas Hadjokas
Publikováno v:
British Journal of Pharmacology. 136:347-352
Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f4fe3b0414be268267f7903357d854
https://doi.org/10.1038/sj.bjp.0704711
https://doi.org/10.1038/sj.bjp.0704711
Autor:
Phillip S. Mushlin, Michael Fill, Xuande Li, Barry J. Cusack, Robert J. Boucek, Philip Palade, Herve A. Gambliel, Susan E. Shadle, Richard D. Olson
Publikováno v:
Toxicology and Applied Pharmacology. 169:168-176
Cardiac effects of anthracyclines or their metabolites may include both the stimulation and inhibition of Ca(2+) release from sarcoplasmic reticulum. In this study, the ability of daunorubicin and its primary metabolite, daunorubicinol, to stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa5d43c2075dcbb03f3211c944ec175
https://doi.org/10.1006/taap.2000.9065
https://doi.org/10.1006/taap.2000.9065
Autor:
Rebecca A. Knighton, Barry J. Cusack, Brad P. Bammel, Susan E. Shadle, Richard D. Olson, Stephan Jay Olson, Phillip S. Mushlin
Publikováno v:
Biochemical Pharmacology. 60:1435-1444
Anthracyclines, such as daunorubicin (Daun), and other quinone-containing compounds can stimulate the formation of toxic free radicals. The present study tests the hypothesis that the quinone moiety of Daun, by increasing free-radical production, dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47fe4cdf0a0be638bfbc0b39db7ea86d
https://doi.org/10.1016/s0006-2952(00)00458-5
https://doi.org/10.1016/s0006-2952(00)00458-5
Publikováno v:
British Journal of Pharmacology. 131:1-4
Anthracyclines can cause cumulative dose-related cardiotoxicity characterized by changes in Ca2+ metabolism, including dysfunction of the sacroplasmic reticulum (SR) and decreased expression of Ca2+-handling proteins, such as the ryanodine receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::356ab93bc2a2562dc5c2425e768cedd1
https://doi.org/10.1038/sj.bjp.0703538
https://doi.org/10.1038/sj.bjp.0703538
Publikováno v:
Drugs & Aging. 7:10-18
With increasing age, there are a number of physiological changes that affect the handling of drugs in the human body. Increases in body fat percentage as well as decreases in lean body mass, hepatic metabolism and renal elimination capacity are of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3babe782250b9cb426826e3f78788b0
https://doi.org/10.2165/00002512-199507010-00002
https://doi.org/10.2165/00002512-199507010-00002
Publikováno v:
Experimental Gerontology. 28:421-433
The twofold to threefold higher incidence of adverse drug reactions in elderly as opposed to younger patients is due mainly to more severe disease and the requirement for more complex drug treatment regimens. The incidence of adverse drug reactions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7091d5c1882161173464e812a5e04e5
https://doi.org/10.1016/0531-5565(93)90068-o
https://doi.org/10.1016/0531-5565(93)90068-o