Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Barry J Thompson"'
Autor:
Nerea Borreguero-Muñoz, Georgina C Fletcher, Mario Aguilar-Aragon, Ahmed Elbediwy, Zoé I Vincent-Mistiaen, Barry J Thompson
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000509 (2019)
The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-associated protein (YAP or YAP1) and Transcriptional Activator with a PDZ domain (TAZ or WW-domain-containing transcriptional activator [WWTR1]), coactivato
Externí odkaz:
https://doaj.org/article/49700236fbce48088ee3945b33c7f241
Autor:
Clara Sidor, Nerea Borreguero-Munoz, Georgina C Fletcher, Ahmed Elbediwy, Oriane Guillermin, Barry J Thompson
Publikováno v:
eLife, Vol 8 (2019)
Mask family proteins were discovered in Drosophila to promote the activity of the transcriptional coactivator Yorkie (Yki), the sole fly homolog of mammalian YAP (YAP1) and TAZ (WWTR1). The molecular function of Mask, or its mammalian homologs Mask1
Externí odkaz:
https://doaj.org/article/c164dd5a41d141f28cc8676d26edc45c
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002429 (2011)
The insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue growth and metabolism in multicellular animals. Although core components of the pathway are well defined, less is known about mechanisms that adjust the sensiti
Externí odkaz:
https://doaj.org/article/251727717e4940c09cb22f17c7e38512
Autor:
Barry J Thompson
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10077 (2010)
The Mal/SRF transcription factor is regulated by the level of G-actin in cells and has important roles in cell migration and other actin-dependent processes in Drosophila. A recent report suggests that Mal/SRF and an upstream regulator, Pico, are req
Externí odkaz:
https://doaj.org/article/9d1fa081337140eb9b6b2fc0267dfe98
Autor:
Teresa T Bonello, Danfeng Cai, Georgina C Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange, Zhe Liu, Jennifer Lippincott‐Schwartz, Jennifer M Kavran, Barry J Thompson
The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed60927d663b1406c463ef1b77686d22
Autor:
Marie-Charlotte Dolmart, John-Paul Kilday, Noreen Eder, Suzanne Claxton, Ambrosius P. Snijders, Junhao Mao, Helen R. Flynn, Torsten Pietsch, Felipe Andreiuolo, Stuart Horswell, Sila K. Ultanir, Federico Roncaroli, Lucy M. Collinson, André T. Lopes, Barry J. Thompson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Eder, N, Roncaroli, F, Dolmart, M-C, Horswell, S, Andreiuolo, F, Flynn, H R, Lopes, A T, Claxton, S, Kilday, J-P, Collinson, L, Mao, J-H, Pietsch, T, Thompson, B, Snijders, A P & Ultanir, S K 2020, ' YAP1/TAZ drives ependymoma-like tumour formation in mice ', Nature Communications, vol. 11, no. 1, pp. 2380 . https://doi.org/10.1038/s41467-020-16167-y
Nature Communications
Eder, N, Roncaroli, F, Dolmart, M-C, Horswell, S, Andreiuolo, F, Flynn, H R, Lopes, A T, Claxton, S, Kilday, J-P, Collinson, L, Mao, J-H, Pietsch, T, Thompson, B, Snijders, A P & Ultanir, S K 2020, ' YAP1/TAZ drives ependymoma-like tumour formation in mice ', Nature Communications, vol. 11, no. 1, pp. 2380 . https://doi.org/10.1038/s41467-020-16167-y
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26c7a0a824fe2ef09f34161b30ba697
https://doaj.org/article/e28a2ae9a5014ff08a75f121065097ec
https://doaj.org/article/e28a2ae9a5014ff08a75f121065097ec
Autor:
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, 12(1):3464. Nature Publishing Group
Nature Communications
S-CORT Consortium 2021, ' Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis ', Nature Communications, vol. 12, 3464 . https://doi.org/10.1038/s41467-021-23717-5
Nature communications, 12(1):3464. Nature Publishing Group
Nature Communications
S-CORT Consortium 2021, ' Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis ', Nature Communications, vol. 12, 3464 . https://doi.org/10.1038/s41467-021-23717-5
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we describe a mouse model of right-sided c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0a5ec9305d4966a39971a5afa4cf77
https://doi.org/10.1038/s41467-021-23717-5
https://doi.org/10.1038/s41467-021-23717-5
Autor:
Rachel A. Ridgway, Barry J. Thompson, Anna Kucharska, Owen J. Sansom, Julia B. Cordero, Nikolaos Angelis, Clara M. Sidor, Pedro Antas, Vivian S. W. Li, Melissa R Rose, Oriane Guillermin, Anna Baulies
Publikováno v:
The EMBO Journal
Wnt signalling induces a gradient of stem/progenitor cell proliferation along the crypt‐villus axis of the intestine, which becomes expanded during intestinal regeneration or tumour formation. The YAP transcriptional co‐activator is known to be r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502f432e7255af12a0ebabb988b99be3
https://doi.org/10.15252/embj.2020105770
https://doi.org/10.15252/embj.2020105770
Autor:
Barry J. Thompson
Publikováno v:
The FEBS journal. 289(3)
The Par-3/Baz family of polarity determinants is highly conserved across metazoans and includes C. elegans PAR-3, Drosophila Bazooka (Baz), human Par-3 (PARD3), and human Par-3-like (PARD3B). The C. elegans PAR-3 protein localises to the anterior pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d6df665264b49cbf99148edf2eda44
https://pubmed.ncbi.nlm.nih.gov/33565714
https://pubmed.ncbi.nlm.nih.gov/33565714