Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Barry J Hoffer"'
Autor:
David Tweedie, Hanuma Kumar Karnati, Roger Mullins, Chaim G Pick, Barry J Hoffer, Edward J Goetzl, Dimitrios Kapogiannis, Nigel H Greig
Publikováno v:
eLife, Vol 9 (2020)
Traumatic brain injury (TBI) is a serious global health problem, many individuals live with TBI-related neurological dysfunction. A lack of biomarkers of TBI has impeded medication development. To identify new potential biomarkers, we time-dependentl
Externí odkaz:
https://doaj.org/article/a33459bcae204b97993da13e520fc0a6
Autor:
Chih-Tung Lin, Daniela Lecca, Ling-Yu Yang, Weiming Luo, Michael T Scerba, David Tweedie, Pen-Sen Huang, Yoo-Jin Jung, Dong Seok Kim, Chih-Hao Yang, Barry J Hoffer, Jia-Yi Wang, Nigel H Greig
Publikováno v:
eLife, Vol 9 (2020)
Traumatic brain injury (TBI) causes mortality and disability worldwide. It can initiate acute cell death followed by secondary injury induced by microglial activation, oxidative stress, inflammation and autophagy in brain tissue, resulting in cogniti
Externí odkaz:
https://doaj.org/article/3c2e1f55fd3a4ffd8982901f2fa50dfe
Autor:
Man-Hau Ho, Yih-Jeng Tsai, Chia-Yen Chen, Anastasia Yang, Thierry Burnouf, Yun Wang, Yung-Hsiao Chiang, Barry J. Hoffer, Szu-Yi Chou
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-22 (2024)
Abstract Background Traumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions and exacerbation of early neurodegeneration; the repair of axonal and synaptic structures is critical for re
Externí odkaz:
https://doaj.org/article/a99233fd0b8446cc9e60cc3921f12614
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106563- (2024)
Externí odkaz:
https://doaj.org/article/4a8fdaad6d87422b91427c0a069d7f0b
Autor:
Renana Baratz-Goldstein, Hanna Deselms, Leore Raphael Heim, Lena Khomski, Barry J Hoffer, Daphne Atlas, Chaim G Pick
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157064 (2016)
Mild traumatic brain injury (mTBI) is recognized as a common injury among children, sportsmen, and elderly population. mTBI lacks visible objective structural brain damage but patients frequently suffer from long-lasting cognitive, behavioral and emo
Externí odkaz:
https://doaj.org/article/7ac519ef0c3741b7aced98dfae0f2126
Autor:
David Tweedie, Koji Fukui, Yazhou Li, Qian-Sheng Yu, Shani Barak, Ian A Tamargo, Vardit Rubovitch, Harold W Holloway, Elin Lehrmann, William H Wood, Yongqing Zhang, Kevin G Becker, Evelyn Perez, Henriette Van Praag, Yu Luo, Barry J Hoffer, Robert E Becker, Chaim G Pick, Nigel H Greig
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156493 (2016)
Traumatic brain injury (TBI), often caused by a concussive impact to the head, affects an estimated 1.7 million Americans annually. With no approved drugs, its pharmacological treatment represents a significant and currently unmet medical need. In ou
Externí odkaz:
https://doaj.org/article/afeb8f2d25b74059bdb714ab09610d3b
Autor:
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial
Externí odkaz:
https://doaj.org/article/42e9f0f96ce54c0abdd8d29f68afa314
Autor:
Katharine Eakin, Renana Baratz-Goldstein, Chiam G Pick, Ofra Zindel, Carey D Balaban, Michael E Hoffer, Megan Lockwood, Jonathan Miller, Barry J Hoffer
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e90617 (2014)
In this study, using two different injury models in two different species, we found that early post-injury treatment with N-Acetyl Cysteine (NAC) reversed the behavioral deficits associated with the TBI. These data suggest generalization of a protoco
Externí odkaz:
https://doaj.org/article/3f04293dc1a44102b53c57a16f436850
Autor:
Katharine Eakin, Yazhou Li, Yung-Hsiao Chiang, Barry J Hoffer, Hilary Rosenheim, Nigel H Greig, Jonathan P Miller
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82016 (2013)
Traumatic brain injury represents a major public health issue that affects 1.7 million Americans each year and is a primary contributing factor (30.5%) of all injury-related deaths in the United States. The occurrence of traumatic brain injury is lik
Externí odkaz:
https://doaj.org/article/db343b0ef27a45b1b65a1b28edbb7ed1
Autor:
Brandon K Harvey, Mikko Airavaara, Jason Hinzman, Emily M Wires, Matthew J Chiocco, Douglas B Howard, Hui Shen, Greg Gerhardt, Barry J Hoffer, Yun Wang
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22135 (2011)
Following the onset of an ischemic brain injury, the excitatory neurotransmitter glutamate is released. The excitotoxic effects of glutamate are a major contributor to the pathogenesis of a stroke. The aim of this study was to examine if overexpressi
Externí odkaz:
https://doaj.org/article/ceadf21b0e594df392dbb9f236231891