A systematic review examining the relationship between cytokines and cachexia in incurable cancer

Autor: D. Robert Paval, Rebekah Patton, James McDonald, Richard J.E. Skipworth, Iain J. Gallagher, Barry J. Laird, the Caledonian Cachexia Collaborative

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 824-838 (2022)

Abstract Cancer cachexia is an unmet clinical need that affects more than 50% of patients with cancer. The systemic inflammatory response, which is mediated by a network of cytokines, has an established role in the genesis and maintenance of cancer a

Externí odkaz: https://doaj.org/article/2ad9fc380ea84ab6ad9657c61d9093e4

The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19

Autor: Josh McGovern, Yassir Al-Azzawi, Olivia Kemp, Peter Moffitt, Conor Richards, Ross D. Dolan, Barry J. Laird, Donald C. McMillan, Donogh Maguire

Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-8 (2022)

Abstract Background Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationship between frailty and

Externí odkaz: https://doaj.org/article/21205e8124fd4ae4a035c93558c48306

The relationship between the BMI‐adjusted weight loss grading system and quality of life in patients with incurable cancer

Autor: Louise Daly, Ross Dolan, Derek Power, Éadaoin Ní Bhuachalla, Wei Sim, Marie Fallon, Samantha Cushen, Claribel Simmons, Donald C. McMillan, Barry J. Laird, Aoife Ryan

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 160-168 (2020)

Abstract Background Weight loss (WL) has long been recognized as an important factor associated with reduced quality of life (QoL) and reduced survival in patients with cancer. The body mass index (BMI)‐adjusted weight loss grading system (WLGS) ha

Externí odkaz: https://doaj.org/article/4201989b101f4619acd1cfe28ebe4c28

Are CT-Derived Muscle Measurements Prognostic, Independent of Systemic Inflammation, in Good Performance Status Patients with Advanced Cancer?

Autor: McMillan, Josh McGovern, Ross D. Dolan, Claribel Simmons, Louise E. Daly, Aoife M. Ryan, Derek G. Power, Marie T. Fallon, Barry J. Laird, Donald C.

Publikováno v: Cancers; Volume 15; Issue 13; Pages: 3497

The present study examined the relationships between CT-derived muscle measurements, systemic inflammation, and survival in advanced cancer patients with good performance status (ECOG-PS 0/1). Data was collected prospectively from patients with advan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::96acf128f6637e12ea3d8bee03466943

The relationship between computed tomography-derived sarcopenia, cardiopulmonary exercise testing performance, systemic inflammation, and survival in good performance status patients with oesophago-gastric cancer undergoing neoadjuvant treatment

Autor: Josh McGovern, Jenna Delaney, Matthew J. Forshaw, Gerard McCabe, Andrew B. Crumley, David McIntosh, Barry J. Laird, Paul G. Horgan, Donald C. McMillan, Stephen T. McSorley, Ross D. Dolan

Publikováno v: McGovern, J, Delaney, J, Forshaw, M, McCabe, G, Crumley, A, McIntosh, D, Laird, B J A, Horgan, P, McMillan, D, McSorley, S & Dolan, R 2022, ' The relationship between computed tomography-derived sarcopenia, cardiopulmonary exercise testing performance, systemic inflammation, and survival in good performance status patients with oesophago-gastric cancer undergoing neoadjuvant treatment ', Journal of Pain and Symptom Management, vol. 8, no. 1, pp. 3-11 . https://doi.org/10.1002/crt2.57

BackgroundThought to capture the nutritional and functional reserve of the cancer patient, whether the computed tomography (CT)-derived sarcopenia score (CT-SS) has complimentary prognostic value to commonly utilized pre-treatment host assessments in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0905ab541c3c24053b71e5be84825b5b
https://www.pure.ed.ac.uk/ws/files/319493390/JCSM_Clinical_Reports_2022_McGovern_The_relationship_between_computed_tomography_derived_sarcopenia_cardiopulmonary.pdf