Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Barry H. Rumack"'
Autor:
Oulfa Boussetta-Charfi, Cornélie Fanton D'Andon, HoanVu Nguyen, Barry H. Rumack, Manon Launay
Publikováno v:
Therapeutic Drug Monitoring. 45:273-276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df6b551184d9a51a5b096624ac422f9d
https://doi.org/10.1097/ftd.0000000000000995
https://doi.org/10.1097/ftd.0000000000000995
Publikováno v:
Arch Toxicol
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. The standard oral or intravenous dosing regimen of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1003af8de3b6ed8ecd89a392374de33a
https://doi.org/10.1007/s00204-021-03211-z
https://doi.org/10.1007/s00204-021-03211-z
Autor:
Jephte Y. Akakpo, Steven C. Curry, Anup Ramachandran, Barry H. Rumack, Matthew W Jaeschke, Hartmut Jaeschke
Publikováno v:
Archives of Toxicology. 95:3377-3391
N-acetylcysteine (NAC) is the only clinically approved antidote against acetaminophen (APAP) hepatotoxicity. Despite its efficacy in patients treated early after APAP overdose, NAC has been implicated in impairing liver recovery in mice. More recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5619678a6d99307ca44f858cc10dc8ad
https://doi.org/10.1007/s00204-021-03142-9
https://doi.org/10.1007/s00204-021-03142-9
Autor:
Chris DeWitt, Marco L.A. Sivilotti, Elizabeth Haney, Margaret Thompson, David W. Johnson, Charlemagne Victorino, Sophie Gosselin, Jason A Lord, Barry H. Rumack, Benoit Bailey, Daniel A. Spyker, Roy Purssell, Nancy G. Murphy, Kathryn Dong, Alberto Nettel-Aguirre, Mark Yarema
Publikováno v:
British Journal of Clinical Pharmacology. 87:3332-3343
Aims Early identification of patients likely to die after acetaminophen (APAP) poisoning remains challenging. We sought to compare the sensitivity and time to fulfilment (latency) of established prognostic criteria. Methods Three physician toxicologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c35a196d066af427df7c9d81d4b5a6d
https://doi.org/10.1111/bcp.14755
https://doi.org/10.1111/bcp.14755
Autor:
Oulfa, Boussetta-Charfi, Cornélie Fanton, D'Andon, HoanVu, Nguyen, Barry H, Rumack, Manon, Launay
Publikováno v:
Therapeutic drug monitoring.
The accepted treatment for patients with acetaminophen/paracetamol overdose includes risk assessment based on the Rumack-Matthew (R-M) nomogram. Inaccurate use of the nomogram may result in improper treatment. Clinicians were surveyed to determine th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::479c6828f39a394da1dc7c99a2c0924b
https://pubmed.ncbi.nlm.nih.gov/35580848
https://pubmed.ncbi.nlm.nih.gov/35580848
Autor:
Barry H. Rumack, Steven C. Curry, Jephte Y. Akakpo, Erik S Fisher, A. Min Kang, Angela Padilla-Jones, Hartmut Jaeschke, Richard Gerkin
Publikováno v:
J Med Toxicol
INTRODUCTION: Acetaminophen (APAP) is commonly ingested in both accidental and suicidal overdose. Oxidative metabolism by cytochrome P450 2E1 (CYP2E1) produces the hepatotoxic metabolite, N-acetyl-p-benzoquinone imine. CYP2E1 inhibition using 4-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ead94b2401326d67b2bd7ca19c84b71
https://doi.org/10.1007/s13181-019-00740-z
https://doi.org/10.1007/s13181-019-00740-z
Autor:
Luqi Duan, Barry H. Rumack, Matthew W Jaeschke, Hartmut Jaeschke, Wen-Xing Ding, Jephte Y. Akakpo, Anup Ramachandran, Bret D. Freudenthal, M.A. Schaich
Publikováno v:
Toxicol Sci
Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the United States and many western countries. However, the only clinically approved antidote, N-acetylcysteine, has a limited therapeutic window. 4-Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d52eb0bbc840de679ef9c543a1dfee
https://doi.org/10.1093/toxsci/kfz077
https://doi.org/10.1093/toxsci/kfz077
Autor:
Mark C Yarema, Daniel A. Spyker, David W Johnson, Jason P Green, Adam Mutsaers, Marco L.A. Sivilotti, Dylan Tucker, Barry H. Rumack
Publikováno v:
Clinical Toxicology. 57:380-386
The Rumack-Matthew nomogram stratifies patients into discrete risk zones following acetaminophen (APAP) overdose. Treatment decisions have traditionally been based on the initial risk zone. "Line-crossing" between zones occurs and is poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4920eba5ffd368488a95e1005c0d0
https://doi.org/10.1080/15563650.2018.1529320
https://doi.org/10.1080/15563650.2018.1529320
Autor:
Luc De Haro, R. Bédry, Scott A. Weinstein, Julian White, A. Schaper, Thomas Zilker, Barry H. Rumack
Publikováno v:
Toxicon. 157:53-65
Mushroom poisoning is a significant and increasing form of toxin-induced-disease. Existing classifications of mushroom poisoning do not include more recently described new syndromes of mushroom poisoning and this can impede the diagnostic process. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::932024143acb251c3f1449b58f6b2b23
https://doi.org/10.1016/j.toxicon.2018.11.007
https://doi.org/10.1016/j.toxicon.2018.11.007