Výsledky vyhledávání - "Barry Grubbs"

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo

Autor: Seint T. Lwin, Javier Esparza, Babatunde O. Oyajobi, Barry Grubbs, James R. Edwards, Gregory R. Mundy, S A Munoz, Claire M. Edwards, Brandon McCluskey

Publikováno v: Blood. 111:2833-2842

There is increasing evidence to suggest that the Wnt signaling pathway plays a critical role in the pathogenesis of myeloma bone disease. In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d44f3d023a56ba69109bb5b16da1af
https://doi.org/10.1182/blood-2007-03-077685

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Caspase-2 deficiency enhances aging-related traits in mice

Autor: Arlan Richardson, Barry Grubbs, Asish R. Chaudhuri, Susan S. Padalecki, Eric de Waal, Yuji Ikeno, Brian Herman, Gregory R. Mundy, Beth Goins, Yingpei Zhang

Publikováno v: Mechanisms of Ageing and Development. 128:213-221

Alteration of apoptotic activity has been observed in a number of tissues in aging mammals, but it remains unclear whether and/or how apoptosis may affect aging. Caspase-2 is a member of the cysteine protease family that plays a critical role in apop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f719655a45ca73362b3dd29ec0099dc
https://doi.org/10.1016/j.mad.2006.11.030

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Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

Autor: Barbara Sherry, Anjana Gupta, Paul J. Williams, Di Chen, Barry Grubbs, Donna Pulkrabek, Babatunde O. Oyajobi, Ming Zhao, Gregory R. Mundy, Giovanni Franchin, Steve Munoz

Publikováno v: Blood. 102:311-319

Recent data have implicated macrophage inflammatory protein-1α (MIP-1α) in multiple myeloma (MM)-associated osteolysis. However, it is unclear whether the chemokine's effects are direct, to enhance osteolysis, or indirect and mediated through a red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137200e57a7c449c791aa2ca61a5e1ac
https://doi.org/10.1182/blood-2002-12-3905

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Transforming Growth Factor-β Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways

Autor: Juan Juan Yin, Barry Grubbs, Sanna M. Kakonen, Theresa A. Guise, Mark Dallas, Suzanne Burns, John M. Chirgwin, Wayne Rankin, Katri Selander, Yong Cui

Publikováno v: Journal of Biological Chemistry. 277:24571-24578

Transforming growth factor (TGF)-beta promotes breast cancer metastasis to bone. To determine whether the osteolytic factor parathyroid hormone-related protein (PTHrP) is the primary mediator of the tumor response to TGF-beta, mice were inoculated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb74f8a634d4d2df615caf7f5351cb4
https://doi.org/10.1074/jbc.m202561200

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Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX

Autor: Charles T. Leach, Ellen Kraig, Nikhil V. Dhurandhar, Barry Grubbs, John Blangero, Harald H H Göring, Robert H. Yolken, Rohina Rubicz

Publikováno v: BMC Research Notes
BMC Research Notes, Vol 4, Iss 1, p 433 (2011)

Background Infection risks vary among individuals and between populations. Here we present information on the seroprevalence of 13 common infectious agents in a San Antonio-based sample of Mexican Americans. Mexican Americans represent the largest an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0cb113269f45d0f6fbcc5f4f76e2c
https://pubmed.ncbi.nlm.nih.gov/22018212

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TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling

Autor: Barry Grubbs, Rachelle W. Johnson, Susan S. Padalecki, Alyssa R. Merkel, Mai P. Nguyen, Lynn M. Matrisian, Julie A. Sterling, Gregory R. Mundy, Babatunde O. Oyajobi

Publikováno v: Cancer research. 71(3)

Breast cancer frequently metastasizes to bone, in which tumor cells receive signals from the bone marrow microenvironment. One relevant factor is TGF-β, which upregulates expression of the Hedgehog (Hh) signaling molecule, Gli2, which in turn increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959ed6ce5006ec9812565d34c4481f73
https://pubmed.ncbi.nlm.nih.gov/21189326

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Detection of myeloma in skeleton of mice by whole-body optical fluorescence imaging

Autor: Steve Munoz, Christi L. Wideman, Babatunde O. Oyajobi, Barry Grubbs, Paul J. Williams, Gregory R. Mundy, Anjana Gupta, Rami Käkönen, I. Ross Garrett, William C. Dougall, Beryl Story, Allison P. Armstrong

Development of new therapies for myeloma has been hindered by the lack of suitable preclinical animal models of the disease in which widespread tumor foci in the skeleton can be detected reliably. Traditional means of detecting skeletal tumor infiltr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9753f4abb5e39078dddc279db20a94
https://europepmc.org/articles/PMC4482358/

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Maspin reduces prostate cancer metastasis to bone

Autor: Susan S. Padalecki, Barry Grubbs, Robin J. Leach, Teresa L. Johnson-Pais, Rosie Bernal, Devon C. Hall

Publikováno v: Urologic oncology. 26(6)

Maspin is a serine protease inhibitor with anti-tumor activity, including inhibition of tumor growth, angiogenesis, invasion, motility, and metastasis. Normal mammary and prostate cells express maspin at high levels. In contrast, breast and prostate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbe481cdfe574b2661ef0dfdbca9833
https://pubmed.ncbi.nlm.nih.gov/18367129

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The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells

Autor: Anjana Gupta, Ming Zhao, Steve Munoz, Julie A. Sterling, Beryl Story, Barry Grubbs, Susan S. Padalecki, Babatunde O. Oyajobi, Gregory R. Mundy

Publikováno v: Cancer research. 66(15)

Parathyroid hormone-related peptide (PTHrP) is a major factor involved in tumor-induced osteolysis caused by breast cancers that have metastasized to bone. However, the molecular mechanisms that mediate PTHrP production by breast cancer cells are not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e7f6128b88a1a4455a467ec57fccd8
https://pubmed.ncbi.nlm.nih.gov/16885353

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Chromosome 18 suppresses prostate cancer metastases

Autor: B. T. Hummer, B. E. Weissman, Juan Juan Yin, Theresa A. Guise, Susan M Padalecki, Korri S. Weldon, Mark Dallas, Barry Grubbs, Devon C. Hall, Xavier T. Reveles, Robin J. Leach, Teresa L. Johnson-Pais, Y. Cui, C. L. Buller

Publikováno v: Urologic oncology. 21(5)

Loss of heterozygosity and allelic imbalance data has shown that there are two distinct regions of loss on chromosome 18q associated with the progression of prostate cancer (CaP). To investigate the functional significance of chromosome 18q loci in C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b9d0660da701a9939f0ffc62972f1b
https://pubmed.ncbi.nlm.nih.gov/14670546

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