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Regulation of muscle growth by multiple ligands signaling through activin type II receptors

Publikováno v: Proceedings of the National Academy of Sciences. 102:18117-18122

Myostatin is a secreted protein that normally functions as a negative regulator of muscle growth. Agents capable of blocking the myostatin signaling pathway could have important applications for treating human muscle degenerative diseases as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e7e2b74b251d8a619cbdb1e362cdd2
https://doi.org/10.1073/pnas.0505996102

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Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation

Autor: Qian Chen, Joost J. Oppenheim, Michele Phulsuksombati, Rong He, Barry Gertz, De Yang, Richard D. Ye

Publikováno v: Journal of Leukocyte Biology. 72:598-607

Immature and mature dendritic cells (iDC and mDC, respectively) migrate to different anatomical sites, e.g., sites of antigen (Ag) deposition and secondary lymphoid organs, respectively, to fulfill their roles in the induction of primary, Ag-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc986919068e0a0dbdd628864e5fd58e
https://doi.org/10.1189/jlb.72.3.598

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Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS

Autor: Lee J. Martin, Barry Gertz, Margaret Wong, Barry A. Chestnut

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 7 (2013)

Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have relative underrepresentation; however, possible tissue and cell differences in mtDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61f561616a6dfd2271cd0d423441065
https://pubmed.ncbi.nlm.nih.gov/24399935

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Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice

Autor: Lee J. Martin, Barry Gertz, Margaret Wong

Publikováno v: Journal of neuropathology and experimental neurology. 71(2)

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease that causes degeneration of motor neurons and paralysis. Approximately 20% of familial ALS cases have been linked to mutations in the copper/zinc superoxide dismutas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f30f80b7973f1bf2984e821edf286a
https://pubmed.ncbi.nlm.nih.gov/22249462

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The Mitochondrial Permeability Transition Pore in Motor Neurons: Involvement in the Pathobiology of ALS Mice

Autor: Ann C. Price, Qing Chang, Barry Gertz, Yan Pan, Jeffery D. Molkentin, Lee J. Martin

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs) that causes paralysis. Some forms of ALS are inherited, caused by mutations in the superoxide dismutase-1 (SOD1) gene. The mechanisms of human mutant SOD1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45622aa2e3bf5958fbdb12a1aaee23f0
https://europepmc.org/articles/PMC2710399/

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Combined administration of antibodies to human interleukin 8 and epidermal growth factor receptor results in increased antimetastatic effects on human breast carcinoma xenografts

Autor: Rosalba, Salcedo, Manuela, Martins-Green, Barry, Gertz, Joost J, Oppenheim, William J, Murphy

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 8(8)

Current antibody-based immunotherapeutic approaches under evaluation for breast carcinoma are limited in target scope. For example, administration of the human epidermal growth factor receptor (EGFR) antibody, alone or in combination with a chemother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3ba653afc16133dc68538d099b98a6a
https://pubmed.ncbi.nlm.nih.gov/12171898

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Acute effect of ephedrine on 24-h energy balance

Autor: John R. Shannon, Keith Gottesdiener, Ming Sun, Kong Y. Chen, David Robertson, Jens Jordan, Stacey Flattery, Mari Rios Candelore, Barry Gertz, Patrick J. Larson

Publikováno v: Clinical Science. 96:483

Ephedrine is used to help achieve weight control. Data on its true efficacy and mechanisms in altering energy balance in human subjects are limited. We aimed to determine the acute effect of ephedrine on 24-h energy expenditure, mechanical work and u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3ef69b07bfc0f6d4105c5ad4aa9cc3
https://doi.org/10.1042/cs19980206

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