Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Barry E, Kennedy"'
1
Akademický článek
NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma
Autor: Barry E. Kennedy, Michael Giacomantonio, J. Patrick Murphy, Samuel Cutler, Maryanne Sadek, Prathyusha Konda, Joao A. Paulo, Gopal P. Pathak, Saskia H.J. Renkens, Stacy Grieve, Jonathan Pol, Steven P. Gygi, Christopher Richardson, Daniel Gaston, Anthony Reiman, Guido Kroemer, Manal O. Elnenaei, Shashi A. Gujar
Publikováno v: Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 695-706 (2022)
Cancer cell energy metabolism plays an important role in dictating the efficacy of oncolysis by oncolytic viruses. To understand the role of multiple myeloma metabolism in reovirus oncolysis, we performed semi-targeted mass spectrometry-based metabol
Externí odkaz: https://doaj.org/article/bb8aca67d04a4d08ab5cbfd23667f48e
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2
Akademický článek
After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism
Autor: Namit Holay, Barry E. Kennedy, J. Patrick Murphy, Prathyusha Konda, Michael Giacomantonio, Tatjana Brauer-Chapin, Joao A. Paulo, Vishnupriyan Kumar, Youra Kim, Mariam Elaghil, Gary Sisson, Derek Clements, Christopher Richardson, Steven P. Gygi, Shashi Gujar
Publikováno v: Frontiers in Immunology, Vol 13 (2023)
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander act
Externí odkaz: https://doaj.org/article/43247c5da956443a994817e22e2a9b5e
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3
Akademický článek
Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis
Autor: Jordan R. Warford, Anna-Claire Lamport, Derek R. Clements, Alicia Malone, Barry E. Kennedy, Youra Kim, Shashi A. Gujar, David W. Hoskin, Alexander S. Easton
Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-21 (2018)
Abstract Proteoglycans are promising therapeutic targets in Multiple Sclerosis (MS), because they regulate many aspects of the immune response. This was studied using surfen, an agent that binds both heparan sulphate proteoglycans (HSPGs) and chondro
Externí odkaz: https://doaj.org/article/798f961447a743bb8b54f75ac1c7b25a
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4
Data from Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus
Autor: Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Oncolytic viruses (OV) such as reovirus preferentially infect and kill cancer cells. Thus, the mechanisms that dictate the susceptibility of cancer cells to OV-induced cytotoxicity hold the key to their success in clinics. Here, we investigated wheth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f851798f8be89f8b7de8621f0d9e167
https://doi.org/10.1158/0008-5472.c.6510912.v1
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6
Supplementary Data from Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus
Autor: Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Raw values for all in vitro and in vivo metabolomic experiments are presented in supplemental tables 1, 7, and 8. Supplemental tables 2, 3, 4, and 5 contain the correlation values and enrichment analysis for all experiments. Supplemental table 6 cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be45bb251be0090da201afb85f9dde3
https://doi.org/10.1158/0008-5472.22421382
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9
Akademický článek
Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1[S]
Autor: Barry E. Kennedy, Mark Charman, Barbara Karten
Publikováno v: Journal of Lipid Research, Vol 53, Iss 12, Pp 2632-2642 (2012)
Mitochondrial cholesterol is maintained within a narrow range to regulate steroid and oxysterol synthesis and to ensure mitochondrial function. Mitochondria acquire cholesterol through several pathways from different cellular pools. Here we have char
Externí odkaz: https://doaj.org/article/8c9c6754469d4c7e95499369aaa926c5
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10
Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy
Autor: Barry E. Kennedy, Shashi Gujar, Maryanne Sadek
Publikováno v: Mol Ther
Oncolytic viruses (OVs) represent a promising new class of cancer therapeutics and cause antitumor effects by two major mechanisms: (1) directly killing cancer cells in a process known as oncolysis, or (2) initiating a powerful antitumor immune respo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa79a9ed13525a8ab2a3ba86d02772e
https://doi.org/10.1016/j.ymthe.2020.03.014
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