Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Barry E, Kennedy"'
1
Akademický článek
Recent Advances in Phytochemical-Based Topical Applications for the Management of Eczema: A Review
Autor: Janani Radhakrishnan, Barry E. Kennedy, Erin B. Noftall, Carman A. Giacomantonio, H. P. Vasantha Rupasinghe
Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 10, p 5375 (2024)
Eczema (atopic dermatitis, AD) is a skin disease characterized by skin barrier dysfunction due to various factors, including genetics, immune system abnormalities, and environmental triggers. Application of emollients and topical drugs such as cortic
Externí odkaz: https://doaj.org/article/1ed50afe712a4e0a831ee6e36aceb596
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2
Akademický článek
NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma
Autor: Barry E. Kennedy, Michael Giacomantonio, J. Patrick Murphy, Samuel Cutler, Maryanne Sadek, Prathyusha Konda, Joao A. Paulo, Gopal P. Pathak, Saskia H.J. Renkens, Stacy Grieve, Jonathan Pol, Steven P. Gygi, Christopher Richardson, Daniel Gaston, Anthony Reiman, Guido Kroemer, Manal O. Elnenaei, Shashi A. Gujar
Publikováno v: Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 695-706 (2022)
Cancer cell energy metabolism plays an important role in dictating the efficacy of oncolysis by oncolytic viruses. To understand the role of multiple myeloma metabolism in reovirus oncolysis, we performed semi-targeted mass spectrometry-based metabol
Externí odkaz: https://doaj.org/article/bb8aca67d04a4d08ab5cbfd23667f48e
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3
Akademický článek
After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism
Autor: Namit Holay, Barry E. Kennedy, J. Patrick Murphy, Prathyusha Konda, Michael Giacomantonio, Tatjana Brauer-Chapin, Joao A. Paulo, Vishnupriyan Kumar, Youra Kim, Mariam Elaghil, Gary Sisson, Derek Clements, Christopher Richardson, Steven P. Gygi, Shashi Gujar
Publikováno v: Frontiers in Immunology, Vol 13 (2023)
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander act
Externí odkaz: https://doaj.org/article/43247c5da956443a994817e22e2a9b5e
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4
Akademický článek
Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis
Autor: Jordan R. Warford, Anna-Claire Lamport, Derek R. Clements, Alicia Malone, Barry E. Kennedy, Youra Kim, Shashi A. Gujar, David W. Hoskin, Alexander S. Easton
Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-21 (2018)
Abstract Proteoglycans are promising therapeutic targets in Multiple Sclerosis (MS), because they regulate many aspects of the immune response. This was studied using surfen, an agent that binds both heparan sulphate proteoglycans (HSPGs) and chondro
Externí odkaz: https://doaj.org/article/798f961447a743bb8b54f75ac1c7b25a
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5
Data from Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus
Autor: Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Oncolytic viruses (OV) such as reovirus preferentially infect and kill cancer cells. Thus, the mechanisms that dictate the susceptibility of cancer cells to OV-induced cytotoxicity hold the key to their success in clinics. Here, we investigated wheth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f851798f8be89f8b7de8621f0d9e167
https://doi.org/10.1158/0008-5472.c.6510912.v1
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7
Supplementary Data from Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus
Autor: Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Raw values for all in vitro and in vivo metabolomic experiments are presented in supplemental tables 1, 7, and 8. Supplemental tables 2, 3, 4, and 5 contain the correlation values and enrichment analysis for all experiments. Supplemental table 6 cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be45bb251be0090da201afb85f9dde3
https://doi.org/10.1158/0008-5472.22421382
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10
DMG26
Autor: Philipp Knopf, Manal O. Elnenaei, Mohamed Abou El Hassan, Julie Wagner, Shashi Gujar, Daniel Gaston, Barry E. Kennedy, Jeanette E. Boudreau, Clinton J. V. Campbell, Samuel D. Cutler, Andrea J. Thoni, Nicholas A. Forward, Darrell White, Marissa Goudie
Publikováno v: The Journal of Molecular Diagnostics. 23:1699-1714
Multiple myeloma presents with numerous primary genomic lesions that broadly dichotomize cases into hyperdiploidy or IgH translocated. Clinically, these large alterations are assessed by fluorescence in situ hybridization (FISH) for risk stratificati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc19ac31a32958294e3941b96a691736
https://doi.org/10.1016/j.jmoldx.2021.08.011
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