Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Barry Dubinsky"'
Autor:
Daniel I. Rosenthal, Pauline J. Sanfilippo, Cheryl P. Kordik, Anil H. Vaidya, Barry Dubinsky, Alfonzo D. Jordan, Allen B. Reitz, Wu-Nan Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2381-2386
A series of pyrido[1,2- a ]benzimidazoles (PBIs) with substitution on the N 5 -nitrogen has been synthesized and found to possess high affinity for the benzodiazepine (BZD) site on the GABA-A receptor. The compounds evaluated include those bearing a
Publikováno v:
Journal of Medicinal Chemistry. 42:2403-2408
A series of 3-aryl-1-(arylsulfonyl)-1,4,5,6-tetrahydropyridazine allosteric modulators of the GABAA receptor was synthesized, and biological activity was examined in vitro and in vivo. Beginning with 1a, stepwise modification of the substituents and
Autor:
Bruce E. Maryanoff, Allen B. Reitz, James J. McNally, Samuel O. Nortey, Pauline J. Sanfilippo, Richard P. Shank, Barry Dubinsky, David F. McComsey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1547-1552
A variety of pyrido[1,2-a]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-f
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:333-338
We have further explored the structure-activity relationships of pyrido[1,2- a ]benzimidazole (PBI) derivatives (viz. prototype 1 ), a novel series of central GABA-A receptor modulators, with the intent of enhancing oral efficacy. A study involving t
Autor:
David F. McComsey, Pauline J. Sanfilippo, Allen B. Reitz, James J. McNally, Bruce E. Maryanoff, Barry Dubinsky, Richard P. Shank, Samuel O. Nortey
Publikováno v:
ChemInform. 30
Autor:
Daniel I. Rosenthal, Alfonzo D. Jordan, Barry Dubinsky, Allen B. Reitz, Wu-Nan Wu, Pauline J. Sanfilippo, Cheryl P. Kordik, Anil H. Vaidya
Publikováno v:
ChemInform. 33
A series of pyrido[1,2- a ]benzimidazoles (PBIs) with substitution on the N 5 -nitrogen has been synthesized and found to possess high affinity for the benzodiazepine (BZD) site on the GABA-A receptor. The compounds evaluated include those bearing a
Autor:
Alfonso J. Tobia, Marvin E. Rosenthale, David A. Shriver, Barry Dubinsky, Jeffery B. Press, Pauline J. Sanfilippo
Publikováno v:
Drug Development Research. 21:277-289
RWJ 20085 is a potent, long-acting local anesthetic that has been studied in vivo and in vitro relative to several clinically active agents. In mice, RWJ 20085 [ED50 = 0.0078% (0.0053–0.011%)] was more potent by perineural infiltration than bupivac
Autor:
Ann Devine, Daniel I. Rosenthal, Coralie Hochman, Samantha DeLuca, Allen B. Reitz, Jeffrey Crooke, Anil H. Vaidya, Alfonzo D. Jordan, Cathy T. Cheo-Isaacs, Barry Dubinsky, Richard P. Shank, Alexandre R. Carter
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 303(2)
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5] imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide) (RWJ-51204) binds selectively and with high affinity (K(i) = 0.2-2 nM) to the benzodiazepine site on GABA(A) receptors. Considering the
Autor:
David A. Demeter, Malcolm K. Scott, Richard P. Shank, Samuel O. Nortey, Allen B. Reitz, Barry Dubinsky
Publikováno v:
Progress in Medicinal Chemistry ISBN: 9780444500908
Agents to treat anxiety have gained in acceptance and importance in the fast pace of life in the second half of this century. The discovery and refinement of the benzodiazepines represented a quantum leap in therapy from early compounds which were es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38e5ee6ddfd1c313d2796c297172ad2
https://doi.org/10.1016/s0079-6468(08)70047-x
https://doi.org/10.1016/s0079-6468(08)70047-x