Výsledky vyhledávání - "Barry D. Luskey"

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

Autor: David A. Williams, Barry D. Luskey, Stuart H. Orkin, Robert E. Donahue, Arthur W. Nienhuis, David I. K. Martin, Tom Moritz, David M. Bodine, Steven W. Kessler

Publikováno v: Blood. 82:1975-1980

Retroviral mediated gene transfer into stem cells has been proposed as therapy for many inherited hematopoietic diseases. Deficiency of the enzyme adenosine deaminase (ADA) results in depletion of T lymphocytes, causing severe combined immunodeficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aeb77933bdc0d4c928c4f1c1f01cce22
https://doi.org/10.1182/blood.v82.7.1975.bloodjournal8271975

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Stem cell factor, interleukin-3, and interleukin-6 promote retroviral- mediated gene transfer into murine hematopoietic stem cells

Autor: Kristina Zsebo, David R. Williams, Margery Rosenblatt, Barry D. Luskey

Publikováno v: Blood. 80:396-402

The efficiency of retroviral-mediated gene transfer into hematopoietic stem cells (HSC) is dependent on the survival and self-renewal of HSC in vitro during retroviral infection. We have examined the effect of prestimulation of bone marrow with vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c83d7eb483b0ac45d35913c446c2efc7
https://doi.org/10.1182/blood.v80.2.396.396

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Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: effect of selectable marker sequences on long-term expression

Autor: Barry D. Luskey, JF Apperley, David A. Williams

Publikováno v: Blood. 78:310-317

Retroviral-mediated gene transfer of human adenosine deaminase (hADA) provides a model system for the development of somatic gene therapy as a therapy for diseases of bone marrow-derived cells. We have previously demonstrated that hADA can be observe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6afba1e18a5cecdea26e1ef546253da6
https://doi.org/10.1182/blood.v78.2.310.310

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Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells

Autor: David A. Williams, Barry D. Luskey, Stuart H. Orkin, JF Apperley, Bing Lim

Publikováno v: Annals of the New York Academy of Sciences. 612

The use of recombinant retroviral vectors to transfer genetic sequences into hematopoietic stem cells (HSC) is one approach to somatic gene therapy. Two limitations of such retroviral vectors are the degree of efficiency of transfer into the reconsti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c261a31056eeac72f68e12029234d313
https://pubmed.ncbi.nlm.nih.gov/2291566

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