Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Barry D. Liboiron"'
Autor:
Robert K. Stuart, Arthur C. Louie, Timothy Callahan, Lawrence D. Mayer, Kamalika Banerjee, Eric Rubenstein, Barry D. Liboiron, Donna Alvarez, Laura C. Michaelis, Laura F. Newell, Qi Wang, Tara L. Lin, Helen S. Pentikis
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Daunorubicin can induce left ventricular dysfunction and QT interval prolongation. This study assessed the effects of CPX-351, a liposomal encapsulation of cytarabine and daunorubicin, on cardiac repolarization. Methods Twenty-six adults with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aea5a51c13241ca9eca2fae06377f3
https://doi.org/10.1007/s00280-019-03856-9
https://doi.org/10.1007/s00280-019-03856-9
Autor:
Lawrence D. Mayer, Barry D. Liboiron
Publikováno v:
Therapeutic Delivery. 5:149-171
While combination chemotherapy has led to measurable improvements in cancer treatment outcomes, its full potential remains to be realized. Nanoscale particles such as liposomes, nanoparticles and polymer micelles have been shown to increase delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8888389ecf790dd42508885051e23041
https://doi.org/10.4155/tde.13.149
https://doi.org/10.4155/tde.13.149
Autor:
Paul Tardi, Sherwin Xie, Barry D. Liboiron, Troy Harasym, Peng Zou, Lawrence D. Mayer, Stephan T. Stern, Sarah L. Skoczen, Scott E. McNeil
Publikováno v:
Journal of Controlled Release. 172:558-567
Pharmacokinetic modeling and simulation is a powerful tool for the prediction of drug concentrations in the absence of analytical techniques that allow for direct quantification. The present study applied this modeling approach to determine active dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebd7ab611e61d6277bdd81f16417339
https://doi.org/10.1016/j.jconrel.2013.04.025
https://doi.org/10.1016/j.jconrel.2013.04.025
Publikováno v:
Molecular Physics. 111:2967-2979
We describe a 1D and 2D electron spin echo envelope modulation investigation of VO2+ adsorbed on hydroxyapatite (HA) at different concentrations and compare with VO2+–triphosphate (TPH) complexes studied previously in detail, in an effort to provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b97789bfafb001218712f9e91a1cc85
https://doi.org/10.1080/00268976.2013.796412
https://doi.org/10.1080/00268976.2013.796412
Publikováno v:
Drug Delivery in Oncology: From Basic Research to Cancer Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e59bc57a81bc2bdc1316055a52780eb5
https://doi.org/10.1002/9783527634057.ch31
https://doi.org/10.1002/9783527634057.ch31
Autor:
Paul Tardi, Lawrence D. Mayer, Xiaowei Xie, Troy Harasym, David Bermudes, Wahseng Lim, Barry D. Liboiron, Xiaoping Huang, Mannie Fan, Nancy Dos Santos
Publikováno v:
Leukemia Research. 34:1214-1223
The objective of this study was to examine the pharmacodynamic basis for the potent preclinical and clinical anti-leukemic activity of CPX-351, a nano-scale liposome formulation of cytarabine and daunorubicin co-encapsulated at a synergistic 5:1 mola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55171575872dd97a39d20b6bed1f5923
https://doi.org/10.1016/j.leukres.2010.01.015
https://doi.org/10.1016/j.leukres.2010.01.015
Publikováno v:
International Journal of Pharmaceutics. 391:248-259
The biophysical characterization of CPX-351, a liposomal formulation of cytarabine and daunorubicin encapsulated in a synergistic 5:1 molar ratio (respectively), is presented. CPX-351 is a promising drug candidate currently in two concurrent Phase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ab7d0997e71dd5933cb242497e8c57
https://doi.org/10.1016/j.ijpharm.2010.02.014
https://doi.org/10.1016/j.ijpharm.2010.02.014
Autor:
Anne Hinderliter, Thomas C. Weber, Connie Cho, April A. Frazier, Awa Dicko, Xiaowei Xie, Lawrence D. Mayer, David S. Cafiso, Jeff F. Ellena, Paul Tardi, Donna Cabral-Lilly, Barry D. Liboiron
Publikováno v:
Pharmaceutical Research. 25:1702-1713
The inter/intramolecular interactions between drugs (floxuridine, irinotecan) and excipients (copper gluconate, triethanolamine) in the dual-drug liposomal formulation CPX-1 were elucidated in order to identify the physicochemical properties that all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b9a6886910dc68b167958f26eec9b1
https://doi.org/10.1007/s11095-008-9561-z
https://doi.org/10.1007/s11095-008-9561-z
Autor:
Chris Orvig, Barry D. Liboiron, Nicolas Aebischer, Katherine H. Thompson, Edmond Lam, Graeme R. Hanson
Publikováno v:
Journal of the American Chemical Society. 127:5104-5115
Significant new insights into the interactions of the potent insulin-enhancing compound bis(maltolato)oxovanadium(IV) (BMOV) with the serum proteins, apo-transferrin and albumin, are presented. Identical reaction products are observed by electron par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef77da06ec7441dda2ba6c740385084
https://doi.org/10.1021/ja043944n
https://doi.org/10.1021/ja043944n
Autor:
Sergei A. Dikanov, Barry D. Liboiron, Katherine H. Thompson, Violet G. Yuen, E. Vera, John H. McNeill, Chris Orvig
Publikováno v:
Bioinorganic Chemistry and Applications
The biological fate of a chelated vanadium source is investigated by/n vivo spectroscopic methods to elucidate the chemical form in which the metal ion is accumulated. A pulsed electron paramagnetic resonance study of vanadyl ions in kidney tissue, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9a4c800f372af1a51907d7c46650b0
https://doi.org/10.1155/s1565363303000062
https://doi.org/10.1155/s1565363303000062