Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Barry D. Gooch"'
Autor:
Jonathan M. Ciencewicki, Barry D. Gooch, Todd M. Gierman, Peter Vandeberg, Katherine Schouest
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Human-plasma-derived immune globulin (IG) is used in augmentation therapy to provide protective levels of antibodies to patients with primary immune deficiency diseases (PIDD) and for prophylaxis against infectious diseases. To maintain the breadth o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690dffb73db1789c3789b4ec3f3599f4
https://doi.org/10.1038/s41598-020-63794-y
https://doi.org/10.1038/s41598-020-63794-y
Autor:
Barry D. Gooch, Bryan R. Cullen
Publikováno v:
Virology. 379(1):118-124
Human APOBEC3 proteins exist in two forms containing either a single cytidine deaminase domain (CDA) or two CDAs. Strikingly, the proteins that are capable of effectively inhibiting the infectivity of Vif-deficient HIV-1 (HIV-1DeltaVif), such as APOB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebccd632bfc8a0360b8d3dfe5e4d1a42
Publikováno v:
ChemBioChem. 6:2247-2254
Helix-threading peptides (HTPs) constitute a new class of small molecules that bind selectively to duplex RNA structures adjacent to helix defects and project peptide functionality into the dissimilar duplex grooves. To further explore and develop th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6004afd63bb7cbc56d958cad082410
https://doi.org/10.1002/cbic.200500285
https://doi.org/10.1002/cbic.200500285
Autor:
Peter A. Beal, Barry D. Gooch
Publikováno v:
Journal of the American Chemical Society. 126:10603-10610
Many important biological processes, from the interferon antiviral response to the generation of microRNA regulators of translation, involve duplex RNA. Small molecules capable of binding duplex RNA structures with high affinity and selectivity will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f62dd761818af07cbd2fb554bf664d
https://doi.org/10.1021/ja047818v
https://doi.org/10.1021/ja047818v
Publikováno v:
Organic Letters. 6:63-66
A synthesis of 4,8-disubstituted 2-phenylquinoline amino acids is reported with the incorporation of one example into a peptide by solid-phase synthesis. The phenylquinoline-containing peptide binds an RNA target with nanomolar affinity (KD = 208 nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b919d5a877898ab77af2861bf058f2b3
https://doi.org/10.1021/ol036094+
https://doi.org/10.1021/ol036094+
Publikováno v:
Chemistry & Biology. 10:663-672
In pursuit of small molecules capable of controlling the function of RNA targets, we have explored the RNA binding properties of peptide-acridine conjugates (PACs). In vitro evolution (SELEX) was used to isolate RNAs capable of binding the PAC Ser-Va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10f3550f37356e2dc61b5ca9a376975
https://doi.org/10.1016/s1074-5521(03)00147-9
https://doi.org/10.1016/s1074-5521(03)00147-9
Publikováno v:
Organicbiomolecular chemistry. 4(4)
Helix-threading peptides (HTPs) bind selectively to sites predisposed to intercalation in folded RNA molecules placing peptide functional groups into the dissimilar grooves of the duplex. Here we report the design and synthesis of new HTPs with quino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23cd891701f55549ff53a69a0d73d47
https://pubmed.ncbi.nlm.nih.gov/16467938
https://pubmed.ncbi.nlm.nih.gov/16467938
Publikováno v:
Organic letters. 6(1)
[reaction: see text] A synthesis of 4,8-disubstituted 2-phenylquinoline amino acids is reported with the incorporation of one example into a peptide by solid-phase synthesis. The phenylquinoline-containing peptide binds an RNA target with nanomolar a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cf24068968042406daefa42f7e27b7d
https://pubmed.ncbi.nlm.nih.gov/14703351
https://pubmed.ncbi.nlm.nih.gov/14703351
Autor:
Peter A. Beal, Barry D. Gooch and
Publikováno v:
Journal of the American Chemical Society. 127:5727-5727
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21777ab09f6ec1f2e7536b60fbc4a2a7
https://doi.org/10.1021/ja0515304
https://doi.org/10.1021/ja0515304
Publikováno v:
ChemBioChem; Dec2005, Vol. 6 Issue 12, p2247-2254, 0p