Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Barry Crook"'
Autor:
Neil Upton, David Virley, Helen Chapman, Martin P. Vidgeon-Hart, Andrew D. Medhurst, Leann P. Quinn, M E Hows, Barry Crook
Publikováno v:
British Journal of Pharmacology. 154:226-233
Background and purpose: The peroxisome proliferator-activated receptor-g (PPARg) agonist pioglitazone has previously been shown to attenuate dopaminergic cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ade69cd1baf2af10434e18a932ba47
https://doi.org/10.1038/bjp.2008.78
https://doi.org/10.1038/bjp.2008.78
Autor:
David Matthew Wilson, Alison M. Ray, Andrew D. Medhurst, Robert P. Davis, Ciaran M. Regan, Andrew G. Foley, Teresa Heslop, Sandrine Ociepka, Michael A. Briggs, Trevor White, Barry Crook, Barry Sidney Orlek, Stephen J. Medhurst, Andrew R. Calver, Brenda K. Trail, Iain P. Chessell, Becky Sargent, Tania O. Stean, Joanne Schogger, Neil Upton, Warren D. Hirst, Gordon Bruton, John B. Davis
Publikováno v:
Biochemical Pharmacology. 73:1182-1194
GSK207040 (5-[(3-cyclobutyl-2,3,4,5-tetrahydro-1 H -3-benzazepin-7-yl)oxy]- N -methyl-2-pyrazinecarboxamide) and GSK334429 (1-(1-methylethyl)-4-({1-[6-(trifluoromethyl)-3-pyridinyl]-4-piperidinyl}carbonyl)hexahydro-1 H -1,4-diazepine) are novel and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6a376319db83a13187d88a7430b550
https://doi.org/10.1016/j.bcp.2007.01.007
https://doi.org/10.1016/j.bcp.2007.01.007
Autor:
A. J. Hunter, Jane E. Cluderay, J. Latcham, Christian Heidbreder, Pippa L Pugh, Jon T. Brown, Charlie Reavill, Lee A. Dawson, Ceri H. Davies, Evelyn Grau, Susan J. Pickering, G Brown, Claire S. Shilliam, Barry Crook, A Howarth, Panida Hemmati, Zoe A. Hughes, Derek C. Rogers, Guillaume J. Hervieu, Stephen M. Harrison, Peter R. Maycox
Publikováno v:
Molecular and Cellular Neuroscience. 24:1170-1179
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA1 is a Gi-coupled seven transmembrane r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f5ca71824413304196e63bb4298e03
https://doi.org/10.1016/j.mcn.2003.09.001
https://doi.org/10.1016/j.mcn.2003.09.001
Autor:
Mark James Bamford, Andrew R. Calver, David Matthew Wilson, Rebecca K. Davis, Nicholas Bailey, Isabel Jm Beresford, Jason Witherington, Susannah Davis, Jon Graham Anthony Steadman, Phillip Jeffrey, Vicky Holland, Joanne Schogger, Christopher A. Parr, Jeffrey Wald, Teresa Heslop, Michael A. Briggs, Terrance A. Panchal, Leanne Harris, Andrew D. Medhurst, Kim Brackenborough, David Kenneth Dean, Tania O. Stean, Brenda K. Trail, Nigel Quashie, Angela Worby, Stephen J. Brough, Barry Crook, James Apps, Andrew K. Takle, Robert P. Davis, Sanjeet Singh Sehmi
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
This Letter describes the discovery of GSK189254 and GSK239512 that were progressed as clinical candidates to explore the potential of H3 receptor antagonists as novel therapies for the treatment of Alzheimer's disease and other dementias. By careful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e541fa0f8606fd8aa20c773c236c2d64
https://pubmed.ncbi.nlm.nih.gov/24269482
https://pubmed.ncbi.nlm.nih.gov/24269482
Autor:
Angela Worby, Mark James Bamford, David Matthew Wilson, Christopher A. Parr, Susannah Davis, Andrew R. Calver, James Apps, Andrew D. Medhurst, Brenda K. Trail, Andrew K. Takle, David Kenneth Dean, Michael A. Briggs, Tom D. Heightman, Trevor White, Isabel Jm Beresford, Tania O. Stean, Robert P. Davis, Sanjeet Singh Sehmi, Terry Panchal, Leanne Harris, Nigel Quashie, Barry Crook, Jon Graham Anthony Steadman, Jason Witherington, Joanne Schogger, Nicholas Bailey
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
This Letter describes the discovery of a novel series of H3 receptor antagonists. The initial medicinal chemistry strategy focused on deconstructing and simplifying an early screening hit which rapidly led to the discovery of a novel series of H3 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f2df3198c9c47dfcdd310f42a1ed70
https://pubmed.ncbi.nlm.nih.gov/24161834
https://pubmed.ncbi.nlm.nih.gov/24161834
Autor:
Ciaran M. Regan, Sandrine Ociepka, Rebecca K. Davis, Kim Brackenborough, Jane E. Cluderay, Alison M. Ray, Jeffrey Wald, Andrew D. Medhurst, M. Isabel Gonzalez, Michael A. Briggs, David Matthew Wilson, Jason Witherington, Isabel J. M. Beresford, Andrew G. Foley, Laurent Lacroix, Tania O. Stean, Joanne Schogger, Robert P. Davis, Andrew R. Calver, Graham Wadsworth, Angela Worby, Eric Southam, John B. Davis, Abbe Martyn, Neil Upton, Declan N.C. Jones, Jennifer C. Roberts, Jane Gartlon, Trevor White, Marie L. Woolley, Lee A. Dawson, Alan R. Atkins, Warren D. Hirst, Carol A. Jennings, Teresa Heslop, Brenda K. Trail, Barry Crook, Jackie Cilia
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 321(3)
6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel histamine H(3) receptor antagonist with high affinity for human (pK(i) = 9.59 -9.90) and rat (pK(i) = 8.51-9.17) H(3) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2455dc58b48aabeec4028425d545f9f
https://pubmed.ncbi.nlm.nih.gov/17327487
https://pubmed.ncbi.nlm.nih.gov/17327487
Autor:
Robert P. Davies, Teresa Heslop, Barry Crook, Rebecca K. Davis, M. Isabel Gonzalez, Andrew D. Medhurst, Tania O. Stean, Martin I. Smith, Jennifer C. Roberts, Sandrine Ociepka, Alison M. Ray, Trevor White, Kim Brackenborough, Michael A. Briggs, Andrew R. Calver, Jeffrey Wald, Ciaran M. Regan, Brenda K. Trail, Jason Witherington, Sharlin Ahmed, Joanne Schogger, David Virley, Andrew G. Foley, David Matthew Wilson, Graham Wadsworth
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe406a31c16360893b5546d83dba722
https://doi.org/10.1016/j.jalz.2006.05.223
https://doi.org/10.1016/j.jalz.2006.05.223
Autor:
Stephen D. Skaper, Shaun McNulty, Frank Maurio, Colin A. Campbell, Paula Tilling, Andrew D. Randall, Elena Fonfria, Cesar Mattei, Christopher D. Benham, Kerstin Hill, Davina E. Owen, Jennifer M Wilson, Jon T. Brown, Barry Crook, Paul R. Murdock
Publikováno v:
Journal of receptor and signal transduction research. 26(3)
We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery occlusion (tM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb71eb04b7c02350c6d56768353854a3
https://pubmed.ncbi.nlm.nih.gov/16777714
https://pubmed.ncbi.nlm.nih.gov/16777714
Autor:
David C. Harrison, Guillaume J. Hervieu, D Smart, Carol A. Jennings, Peter R. Maycox, Barry Crook
Publikováno v:
Neuroscience. 120(2)
Bombesin receptor subtype 3 (BRS-3) is an orphan G-protein coupled receptor that shares between 47 and 51% homology with other known bombesin receptors. The natural ligand for BRS-3 is currently unknown and little is known about the mechanisms regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5946cea2e03f2e3462f96694158a32
https://pubmed.ncbi.nlm.nih.gov/12890504
https://pubmed.ncbi.nlm.nih.gov/12890504
Autor:
J Roberts, M Stammers, C.A Campbell, J Meakin, David C. Harrison, R.P. Davis, J Price, Barry Crook, K Deen, D Michalovich, Peter R. Maycox
Publikováno v:
Neuroscience. 96(1)
Members of the death receptor family may play a prominent role in developmental and pathological neuronal cell death. We report the expression of the TR3 and TR7 death receptors in the adult human and rat central nervous system. Whereas expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05b6218145d33372f1082205e4791ee
https://pubmed.ncbi.nlm.nih.gov/10777386
https://pubmed.ncbi.nlm.nih.gov/10777386