Výsledky vyhledávání - "Barry C. Peterson"

The Disposition and Metabolism of Naveglitazar, a Peroxisome Proliferator-Activated Receptor α-γ Dual, γ-Dominant Agonist in Mice, Rats, and Monkeys

Autor: Jason T. Johnson, Ping Yi, Barry C. Peterson, David A. Jackson, Todd A. Gillespie, Chad E. Hadden, William F. Annes

Publikováno v: Drug Metabolism and Disposition. 35:51-61

Naveglitazar [LY519818; benzenepropanoic acid, alpha-methoxy-4-[3-(4-phenoxyphenoxy)propoxy], (alpha-S)-] is a nonthiozolidinedione peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist that has shown glucose-lowering po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb194141f5422312d383039626f2956c
https://doi.org/10.1124/dmd.106.012328

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An Enantioselective Synthesis of Cis Perhydroisoquinoline LY235959

Autor: Harkness Allen Robert, Barry C. Peterson, Vien V. Khau, Jerry W. Misner, Marvin M. Hansen, Carl Franklin Indianapolis Bertsch, Michael E. LeTourneau, John Allan Rieck, D. R. Hutchison, Kevin A. Sullivan, Ian G. Wright, Michael J. Martinelli, Huff Bret Eugene

Publikováno v: The Journal of Organic Chemistry. 63:775-785

A novel synthesis of NMDA receptor antagonist LY235959 (1) has been achieved in 13% overall yield and 17 steps from (R)-pantolactone (7). Highlights of the synthesis include (a) use of a chiral auxiliary controlled asymmetric Diels-Alder reaction to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee14790b74cfd25ce5698b7dcb5a24fa
https://doi.org/10.1021/jo9717649

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Synthetic Studies toward the Partial Ergot Alkaloid LY228729, a Potent 5HT1A Receptor Agonist

Autor: J. D. Marshall, M. A. Carr, Marvin Robert Leanna, Michael J. Martinelli, P. E. Creviston, Varie David Lee, Kress Thomas Joseph, James P. Wepsiec, Joseph H. Kennedy, Vien V. Khau, D. R. Hutchison, Barry C. Peterson

Publikováno v: The Journal of Organic Chemistry. 62:8640-8653

Synthetic studies on LY228729 (3) afforded two innovative approaches for the construction of this class of partial ergoline 5HT1a receptor agonists. The first synthesis is based upon a diastereoselective epoxidation of racemic olefin 5, followed by r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d54d41025e6c8b5c0ea77d30e16aa164
https://doi.org/10.1021/jo971256z

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Diastereoselectivity in the heterogeneous hydrogenation reactions of phosphorous substituted olefins

Autor: Barry C. Peterson, Naresh K. Nayyar, Huff Bret Eugene, Vien V. Khau, Michael J. Martinelli, Michael E. LeTourneau

Publikováno v: Tetrahedron Letters. 38:8627-8630

Phosphorous substituted methylenecyclohexane olefins show enhanced diasteroselectivity in heterogeneous hydrogenation reactions using Pd/C. A model system, derived from 4-t-butylcyclohexanone was used to explore the effects of solvent polarity and ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a32b7d16b379f48c76e1367d284cce81
https://doi.org/10.1016/s0040-4039(97)10371-9

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Diastereoselective synthesis of the cis-octahydronaphthalene nucleus of superstolides A and B

Autor: William R. Roush, Barry C. Peterson, Jennifer A. Champoux

Publikováno v: Tetrahedron Letters. 37:8989-8992

A highly diastereoselective synthesis of 4 via the intramolecular Diels-Alder reaction of trienal 3 is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7021be9cac0bc7e27f035210e5161fc3
https://doi.org/10.1016/s0040-4039(96)02110-7

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Stereoselective Epoxidations and Electrophilic Additions to Partial Ergot Alkaloids and Conformationally-Fixed Styrenes. Experimental and Theoretical Modeling Evidence for the Importance of Torsional Steering as a Stereocontrol Element

Autor: Yun-Dong Wu, Michael J. Martinelli, James E. Audia, D. R. Hutchison, J. J. Droste, Barry C. Peterson, M. R. Leanna, Vien Van Khau, K. N. Houk

Publikováno v: The Journal of Organic Chemistry. 59:2204-2210

Partial ergot alkaloid substrates and related conformationally-fixed styrenes undergo epoxidation, osmium tetraoxide dihydroxylation, and hydrobromination with a level of stereoselectivity which cannot be explained by steric control but is consistent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a4461b940d8399484cfa64bf1868d7f
https://doi.org/10.1021/jo00087a042

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A novel, stereoselective synthesis of cis,4a (S), 8a(R)-decahydro-6(2H)-isoquinolones from meroquinene esters

Autor: Michael J. Martinelli, Kevin A. Sullivan, Barry C. Peterson, Darrell R. Hutchicon, Vien V. Khau

Publikováno v: Tetrahedron Letters. 34:5413-5416

Intramolecular cyclization of N-acylated meroquinene t-butyl esters in cold H2SO4 cleanly afforded cis-4a(S), 8a(R)-decahydro-6(2H)-isoquinolones with cmnplete stereocontrol in ⪢95% yield. Formation of the meroquinene esters from cinchona alkaloid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::676ac777dcaf0c33975333153ebeb6ad
https://doi.org/10.1016/s0040-4039(00)73922-0

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ChemInform Abstract: A Concise, Stereoselective Synthesis of Picenadol

Autor: Michael J. Martinelli, Barry C. Peterson

Publikováno v: ChemInform. 22

A four-step stereoselective synthesis of picenadol ( 1 ) is reported, 1,3-Dimethyl-4-piperidone ( 3 ) underwent Horner-Wadsworth-Emmons reaction under conditions that did not yield double-bond isomerization, followed by a directed 1,4-addition with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36b32da4a9a7b7d5b486d616d8d71067
https://doi.org/10.1002/chin.199141164

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