Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Barry C, Finzel"'
Autor:
William M. McCue, Barry C. Finzel
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 207-214 (2021)
Externí odkaz:
https://doaj.org/article/ce2f1ff4543a4520b694b8e38a32f09f
Autor:
Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Carrie M. Wilmot, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Alzheimer’s disease (AD) was first described by Alois Alzheimer over 100 years ago, but there is still no overarching theory that can explain its cause in detail. There are also no effective therapies to treat either the cause or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d23dbfa9d69eedac74f0ee60beb7c20
https://doi.org/10.1021/acsptsci.1c00251
https://doi.org/10.1021/acsptsci.1c00251
Autor:
Merlin Bresinsky, Jessica M. Strasser, Alexander Hubmann, Bernadette Vallaster, William M. McCue, Jessica Fuller, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
Arch Pharm (Weinheim)
Since the discovery of the caspase-2 (Casp2)-mediated Δtau314 cleavage product and its associated impact on tauopathies such as Alzheimer's disease, the design of selective Casp2 inhibitors has become a focus in medicinal chemistry research. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b4fd317071c944f65f1b4f880f97e
https://pubmed.ncbi.nlm.nih.gov/35642311
https://pubmed.ncbi.nlm.nih.gov/35642311
Publikováno v:
Carbohydrate Polymers. 300:120255
Hyaluronan (HA) plays important roles in a wide range of biological events. The principal receptor of HA in the human body is the Cluster of Differentiation 44 (CD44). To enhance the binding between HA and CD44, a new approach was designed to take ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3440ea9b6e288bc83674e3b2e507a7
https://doi.org/10.1016/j.carbpol.2022.120255
https://doi.org/10.1016/j.carbpol.2022.120255
Publikováno v:
Biological Approaches to Rational Drug Design ISBN: 9781003069294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15aeecbf8ba25e825a521b9f6faa4725
https://doi.org/10.1201/9781003069294-2
https://doi.org/10.1201/9781003069294-2
Autor:
Allison A. Bauman, William McCue, Michael D. Howe, Barry C. Finzel, Shannon Lynn Kordus, Elise A. Lamont, Anthony D. Baughn
Antimicrobial agents that target a specific pathogen of interest is the gold standard in drug design. para-Aminosalicylic acid (PAS), remains a cornerstone therapy, in the treatment against Mycobacterium tuberculosis, owing to its high level of selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974ef560219b384ec6c6cd5dbc260d88
https://doi.org/10.1101/2020.09.18.304022
https://doi.org/10.1101/2020.09.18.304022
Autor:
Barry C. Finzel, Rachit Shah, Andrew L Zhou, Sidath C. Kumarapperuma, Carston R. Wagner, Alexander M. Strom, Kimberly M. Maize
Publikováno v:
Molecular Pharmaceutics. 14:3987-3997
Nucleotide analogues that incorporate a metabolically labile nucleoside phosphoramidate (a ProTide) have found utility as prodrugs. In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202cf8d9561b2b3b4a4368c8a2eefa0f
https://doi.org/10.1021/acs.molpharmaceut.7b00664
https://doi.org/10.1021/acs.molpharmaceut.7b00664
Publikováno v:
Journal of the American Chemical Society. 139:7132-7135
Mechanism-based inhibitors (MBIs) are widely employed in chemistry, biology, and medicine because of their exquisite specificity and sustained duration of inhibition. Optimization of MBIs is complicated because of time-dependent inhibition resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c1d22e09b2811fc5fb75e131439f32
https://doi.org/10.1021/jacs.7b00962
https://doi.org/10.1021/jacs.7b00962
Autor:
Alexander M. Strom, Cristina D. Peterson, Carolyn A. Fairbanks, Kelley F. Kitto, Maxwell Dillenburg, Carston R. Wagner, Rachit Shah, George L. Wilcox, Barry C. Finzel
Publikováno v:
ACS chemical neuroscience. 10(10)
The interactions between the mu-opioid (MOR) and N-methyl-d-aspartate receptor (NMDAR) constitute an area of intense investigation because of their contributions to maladaptive neuroplasticity. Recent evidence suggests that their association requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9560d2d424c36968fd42305165527ba8
https://pubmed.ncbi.nlm.nih.gov/31503445
https://pubmed.ncbi.nlm.nih.gov/31503445
Autor:
Rachit Shah, Kimberly M. Maize, Harrison T. West, Carston R. Wagner, Barry C. Finzel, Alexander M. Strom
Publikováno v:
Journal of molecular biology. 430(17)
Inherited peripheral neuropathies are a group of neurodegenerative disorders that clinically affect 1 in 2500 individuals. Recently, genetic mutations in human histidine nucleotide-binding protein 1 (hHint1) have been strongly and most frequently ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2d7446c2330ea9d221d55514ea3afb
https://pubmed.ncbi.nlm.nih.gov/29787766
https://pubmed.ncbi.nlm.nih.gov/29787766