Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Barry A. Wolitzky"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1-4
A series of imides and lactams derived from 4-amino-N-benzylpyroglutamyl- l -phenylalanine was prepared and evaluated for activity as VCAM/VLA-4 antagonists. Imides were more potent than the corresponding lactams; several had subnanomolar IC50s in an
Autor:
Dorota Miklowski, Richard V. Trilles, Robert William Guthrie, Karen Rowan, Gerry Kaplan, Nicolas Huby, Barry A. Wolitzky, Jefferson Wright Tilley, Virginia Schwinge, Francis A. Mennona, Tai-Nan Huang, Li Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:729-733
A series of N-(N-benzylpyroglutamyl)-4-substituted-L-phenylalanine derivatives was prepared as VLA-4/VCAM antagonists. Analogues substituted by electron deficient benzoylamino groups bearing bulky ortho substituents had low-nM potency in an ELISA ass
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 273:H1903-H1908
Gene-targeted mice are now routinely employed as tools for defining the contribution of different leukocyte and endothelial cell adhesion molecules to the leukocyte recruitment and tissue injury associated with acute and chronic inflammation. The obj
Autor:
Sarkis Meterissian, Barry A. Wolitzky, Robert S. Bresalier, Christine R. Norton, Pnina Brodt, Lucia Fallavollita
Publikováno v:
International Journal of Cancer. 71:612-619
E-selectin is a cytokine-inducible endothelial cell adhesion receptor which is involved in the process of leukocyte rolling, the first in a cascade of interactions leading to leukocyte transmigration. Several studies have implicated this receptor in
Autor:
Kim W. McIntyre, Unsu Jung, Carroll L. Ramos, Eric J. Kunkel, Barry A. Wolitzky, Klaus Ley, Christine R. Norton, Kathleen M. Gillooly, Roland Bosse, Dietmar Vestweber, Michael B. Lawrence
Publikováno v:
Blood. 89:3009-3018
The selectins are inducible adhesion molecules critically important for the inflammatory response. We investigate here the functional effects of three monoclonal antibodies (MoAbs) raised against murine E-selectin (9A9, 10E6, and 10E9.6) on neutrophi
Publikováno v:
Clinical Immunology and Immunopathology. 83:45-52
The initial contact between leukocytes and the vascular endothelium at sites of inflammation is mediated by selectins. The purpose of this study was to investigate the role of the two selectins expressed on the vascular endothelium, E-selectin and P-
The Association between α4-Integrin, P-Selectin, and E-Selectin in an Allergic Model of Inflammation
Autor:
Paul Kubes, C. Wayne Smith, Daniel C. Bullard, Barry A. Wolitzky, Arthur L. Beaudet, Samina Kanwar, Michael J. Hickey
Publikováno v:
The Journal of Experimental Medicine
In this study, we examined the relationship between the endothelial selectins (P-selectin and E-selectin) and whether they are critical for alpha4-integrin-dependent leukocyte recruitment in inflamed (late phase response), cremasteric postcapillary v
Autor:
K J Kim, Barry A. Wolitzky, Philip C. Familletti, Daniel K. Burns, Christine R. Norton, Michael Anostario, Victoria L. Wilkinson, Shirley Li, J.M. Rumberger, David H. Presky
Publikováno v:
Journal of Biological Chemistry. 269:4431-4437
To study the structural characteristics of E-selectin necessary for mediating cell adhesion, we examined the role of the consensus repeat (CR) domains in E-selectin function. Soluble constructs containing different numbers of CR domains were stably e
Autor:
Pramod Joshi, Angela Hanglow, Karen Rowan, Jefferson Wright Tilley, Charles M. Cook, Gerry Kaplan, Barry A. Wolitzky, Nader Fotouhi, David C. Fry, Virginia Schwinge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1171-1173
The Asp-Pro sequence of the cyclic peptide Ac-HN-Tyr-Cys*-Asp-Pro-Cys*-OH (1) could be replaced with the achiral dipeptide mimetic 1-(2-aminoethyl)cyclpentylcarboxylic acid with retention of potent inhibition of the VCAM-VLA-4 interaction.
Autor:
Barry A. Wolitzky, Virginia Schwinge, Karen Rowan, Pramod Joshi, Jefferson Wright Tilley, Nader Fotouhi
Publikováno v:
ChemInform. 31
Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependant on ring size