Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Barry A. Morgan"'
Autor:
Huiyong Ma, James B. Murray, Huadong Luo, Xuemin Cheng, Qiuxia Chen, Chao Song, Cong Duan, Ping Tan, Lifang Zhang, Jian Liu, Barry A. Morgan, Jin Li, Jinqiao Wan, Lisa M. Baker, William Finnie, Lucie Guetzoyan, Richard Harris, Nicole Hendrickson, Natalia Matassova, Heather Simmonite, Julia Smith, Roderick E. Hubbard, Guansai Liu
Publikováno v:
RSC Medicinal Chemistry. 13:1341-1349
We describe a novel approach for screening fragments against a protein that combines the sensitivity of DNA-encoded library technology with the ability of fragments to explore what will bind. Each of the members of the library consists of a fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769d6828e3d693dc0b393f77ff842ff8
https://doi.org/10.1039/d2md00197g
https://doi.org/10.1039/d2md00197g
Autor:
Dominik K. Kölmel, Jinqiao Wan, Barry A. Morgan, Hongyao Zhu, Mark Edward Flanagan, Sylvie K. Sakata, Anthony R. Harris
Publikováno v:
The Chemical Record. 21:616-630
This Personal Account describes the authors' foray into DNA-encoded libraries. The article addresses several key aspects of this hit generation technology, from the development of new synthetic methodology to the subsequent conception, design, and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10728fc7eb0789d60bc42ea8e82521f4
https://doi.org/10.1002/tcr.202000148
https://doi.org/10.1002/tcr.202000148
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0b93599ae79500f98919ddfa6e48aa
https://doi.org/10.1021/acsmedchemlett.0c00029
https://doi.org/10.1021/acsmedchemlett.0c00029
Autor:
Barry A. Morgan
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783031186288
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848a681f51d7781fa6cb68e55459e172
https://doi.org/10.1007/7355_2022_152
https://doi.org/10.1007/7355_2022_152
Autor:
Paolo A. Centrella, Peng Li, G Joseph Franklin, Svetlana L. Belyanskaya, Joseph P. Marino, Steven R. Skinner, Barry A. Morgan, Matthew A. Clark, Jason W. Dodson, Jeffrey A. Messer, Yun Ding, Jennifer L. DeLorey, David I. Israel
Publikováno v:
Bioorganicmedicinal chemistry. 41
Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ef26aa0ff6dd53c73f4758004748fd
https://pubmed.ncbi.nlm.nih.gov/34023664
https://pubmed.ncbi.nlm.nih.gov/34023664
Autor:
Anthony R. Harris, Barry A. Morgan, Jinqiao Wan, Mark Edward Flanagan, Sylvie K. Sakata, Dominik K. Kölmel, Hongyao Zhu
Publikováno v:
The Chemical Record. 21:615-615
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423db3ee1f1736f105c142060f52c457
https://doi.org/10.1002/tcr.202180401
https://doi.org/10.1002/tcr.202180401
Autor:
John W. Cuozzo, Cynthia H. Chiu, Barry A. Morgan, Steven R. Skinner, Matthew A. Clark, Jeffrey A. Messer, Yun Ding, Monique F. Murray-Thompson, Rosalie Matico, Christopher C. Arico-Muendel, David I. Israel, Fan Li, Jennifer L. DeLorey, Heather O’Keefe
Publikováno v:
ACS Medicinal Chemistry Letters. 6:888-893
The aggrecan degrading metalloprotease ADAMTS-4 has been identified as a novel therapeutic target for osteoarthritis. Here, we use DNA-encoded Library Technology (ELT) to identify novel ADAMTS-4 inhibitors from a DNA-encoded triazine library by affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f245039b243867a2c92f0616dd1d33a
https://doi.org/10.1021/acsmedchemlett.5b00138
https://doi.org/10.1021/acsmedchemlett.5b00138
Autor:
Can Xie, Ching-Hsuan Tsai, Steven R. Skinner, David I. Israel, Koichi Yuki, Kenneth E Lind, John W. Cuozzo, Timothy A. Springer, Ghotas Evindar, Christopher S. Kollmann, Barry A. Morgan, Motomu Shimaoka, Xiaopeng Bai, Hongfang Yang, Zhengrong Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2353-2365
The inhibition of protein-protein interactions remains a challenge for traditional small molecule drug discovery. Here we describe the use of DNA-encoded library technology for the discovery of small molecules that are potent inhibitors of the intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303ea5f8e95be6391a41805ecede6e03
https://doi.org/10.1016/j.bmc.2014.01.050
https://doi.org/10.1016/j.bmc.2014.01.050
Autor:
Hongwei Qi, James F. Callahan, Brian Peck, Catherine Booth-Genthe, Edit Kurali, Wensheng Xie, Sharon Sweitzer, Joseph P. Marino, Stephanie Chen, Chad Quinn, Benjamin Schwartz, David J. Behm, Ruth J. Mayer, Svetlana L. Belyanskaya, Marc Galop, Brian Bolognese, Barry A. Morgan, Patricia L. Podolin, Mary S. Barnette, Yun Ding, Sandra Umbrecht, Xiaojun Zhang, Joseph F. Foley, David I. Israel, Edward Long, Penny Zhu
Publikováno v:
Prostaglandins & Other Lipid Mediators. :25-31
Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol). EETs, endothelium-deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5391100f845f30972b4b633e3a2af2
https://doi.org/10.1016/j.prostaglandins.2013.02.001
https://doi.org/10.1016/j.prostaglandins.2013.02.001
Autor:
Paolo A. Centrella, Christopher C. Arico-Muendel, Gary M. Olson, Jennifer L Svendsen, Matthew T. Labenski, Steven R. Skinner, Charles D. Thompson, Christopher L. Paradise, Dennis Benjamin, Barbara C. Sluboski, Kenneth E Lind, Brooke D. Contonio, Teresa M Caiazzo, Christopher Self, Gerhard Hannig, Barry A. Morgan, William F. Westlin, Elisabeth Doyle, Charles M. Cook, Kerry White, Lily Lee Searle
Publikováno v:
Journal of Medicinal Chemistry. 52:8047-8056
Inhibition of methionine aminopeptidase-2 (MetAP2) represents a novel approach to antiangiogenic therapy. We describe the synthesis and activity of fumagillin analogues that address the pharmacokinetic and safety liabilities of earlier candidates in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e398dafef0541f273d8ed530bd50f76
https://doi.org/10.1021/jm901260k
https://doi.org/10.1021/jm901260k