OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Autor: Marchetti C; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Swartzwelter B; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Gamboni F; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Neff CP; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Richter K; Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Centre for Lung Research, Justus-Liebig-University Giessen, 35390 Giessen, Germany., Azam T; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Carta S; Cell Biology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria 'San Martino'-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy., Tengesdal I; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045., Henry C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30307., Jones GS; Chemic Laboratories, Inc., Canton, MA 02021., Goodrich SA; Chemic Laboratories, Inc., Canton, MA 02021., St Laurent JP; Chemic Laboratories, Inc., Canton, MA 02021., Jones TM; J&S Studies, Inc., College Station, TX 77845., Scribner CL; Olatec Therapeutics LLC, New York, NY 10065., Barrow RB; Olatec Therapeutics LLC, New York, NY 10065., Altman RD; Department of Rheumatology, University of California, Los Angeles, CA 90404., Skouras DB; Olatec Therapeutics LLC, New York, NY 10065., Gattorno M; Unita' Operativa Complessa Pediatria 2, G. Gaslini Institute, 16100 Genova, Italy., Grau V; Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Centre for Lung Research, Justus-Liebig-University Giessen, 35390 Giessen, Germany., Janciauskiene S; Department of Respiratory Medicine, German Center for Lung Research, Hannover Medical School, 30625 Hannover, Germany., Rubartelli A; Cell Biology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria 'San Martino'-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy., Joosten LAB; Department of Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Dinarello CA; Department of Medicine, University of Colorado Denver, Aurora, CO 80045; cdinare333@aol.com.; Department of Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Feb 13; Vol. 115 (7), pp. E1530-E1539. Date of Electronic Publication: 2018 Jan 29.