OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Autor: Marchetti C; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Swartzwelter B; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Gamboni F; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Neff CP; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Richter K; Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Centre for Lung Research, Justus-Liebig-University Giessen, 35390 Giessen, Germany., Azam T; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Carta S; Cell Biology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria 'San Martino'-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy., Tengesdal I; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045., Henry C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30307., Jones GS; Chemic Laboratories, Inc., Canton, MA 02021., Goodrich SA; Chemic Laboratories, Inc., Canton, MA 02021., St Laurent JP; Chemic Laboratories, Inc., Canton, MA 02021., Jones TM; J&S Studies, Inc., College Station, TX 77845., Scribner CL; Olatec Therapeutics LLC, New York, NY 10065., Barrow RB; Olatec Therapeutics LLC, New York, NY 10065., Altman RD; Department of Rheumatology, University of California, Los Angeles, CA 90404., Skouras DB; Olatec Therapeutics LLC, New York, NY 10065., Gattorno M; Unita' Operativa Complessa Pediatria 2, G. Gaslini Institute, 16100 Genova, Italy., Grau V; Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Centre for Lung Research, Justus-Liebig-University Giessen, 35390 Giessen, Germany., Janciauskiene S; Department of Respiratory Medicine, German Center for Lung Research, Hannover Medical School, 30625 Hannover, Germany., Rubartelli A; Cell Biology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria 'San Martino'-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy., Joosten LAB; Department of Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Dinarello CA; Department of Medicine, University of Colorado Denver, Aurora, CO 80045; cdinare333@aol.com.; Department of Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Feb 13; Vol. 115 (7), pp. E1530-E1539. Date of Electronic Publication: 2018 Jan 29.

NLRP3 inflammasome-induced pyroptosis and serum ASC specks are increased in patients with cardiogenic shock.

Autor: Kogel, Alexander, Baumann, Lisa, Maeder, Christina, Büttner, Petra, Thiele, Holger, Kneuer, Jasmin M., Boeckel, Jes-Niels, Laufs, Ulrich, Gaul, Susanne

Publikováno v: American Journal of Physiology: Heart & Circulatory Physiology; Oct2024, Vol. 327 Issue 4, pH869-H879, 11p

Novel therapeutic approaches for the primary hyperoxalurias.

Autor: Belostotsky, Ruth¹, Frishberg, Yaacov^1,2 yaacovf@ekmd.huji.ac.il

Publikováno v: Pediatric Nephrology. Sep2021, Vol. 36 Issue 9, p2593-2606. 14p. 2 Diagrams, 1 Chart.

The NLRP3 inflammasome: role in the pathobiology of chronic pain.

Autor: Chen, Chen, Smith, Maree T.

Publikováno v: Inflammopharmacology; Aug2023, Vol. 31 Issue 4, p1589-1603, 15p

Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases.

Autor: Seok, Jin Kyung, Kang, Han Chang, Cho, Yong-Yeon, Lee, Hye Suk, Lee, Joo Young

Publikováno v: Archives of Pharmacal Research; Jan2021, Vol. 44 Issue 1, p16-35, 20p