Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Barrie Peck"'
Autor:
Shayin V. Gibson, Elena Tomas Bort, Lucía Rodríguez-Fernández, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Ulrich auf dem Keller, Andrea Agnoletto, Cathrin Brisken, Barrie Peck, Angus J. Cameron, John F. Marshall, J. Louise Jones, Edward P. Carter, Richard P. Grose
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus p
Externí odkaz:
https://doaj.org/article/121dd275e1f548edb93a722fbf4391bf
Autor:
Karim Bensaad, Elena Favaro, Caroline A. Lewis, Barrie Peck, Simon Lord, Jennifer M. Collins, Katherine E. Pinnick, Simon Wigfield, Francesca M. Buffa, Ji-Liang Li, Qifeng Zhang, Michael J.O. Wakelam, Fredrik Karpe, Almut Schulze, Adrian L. Harris
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 349-365 (2014)
Summary: An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were indu
Externí odkaz:
https://doaj.org/article/e1e264078b5c49b6b6c2525e5f12d70f
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1353-1363 (2013)
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour pr
Externí odkaz:
https://doaj.org/article/9b23413a00a54915bb2d9da9c958a4f0
Autor:
Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Publikováno v:
Cancer Research. 83:P6-10
Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with oestrogen receptor (ER+) breast cancer (BC) where they are enriched in metastatic disease and are associated
Autor:
Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. FASN and B. DGAT inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296bb68cd5c019936a1ef3f8f3f2c884
https://doi.org/10.1158/1535-7163.22508365
https://doi.org/10.1158/1535-7163.22508365
Autor:
Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60daf610bff0e2bf95b43c86f86c0cb4
https://doi.org/10.1158/1535-7163.22508368.v1
https://doi.org/10.1158/1535-7163.22508368.v1
Autor:
Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. ACC and B. PDHK inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc03940dab83b7d2ca0a563a7288b02
https://doi.org/10.1158/1535-7163.22508362.v1
https://doi.org/10.1158/1535-7163.22508362.v1
Autor:
Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones
GI50 calculation of spheroids treated with inhibitors. (A) MDA-MB-468 on day 8 and (B) PC3 spheroids on day 12 treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Between 5 and 15 sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7333ce6954bf5cbb452d5e1691c771
https://doi.org/10.1158/1535-7163.22508371
https://doi.org/10.1158/1535-7163.22508371
Autor:
Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones
Chemical structure of drugs that inhibit metabolic enzymes FASN (AZ22), ACC (AZ52), DGAT (AZ17), PDHK (AZ30), and cell signalling kinase enzymes PI3K (AZ46), AKT (AZ28) and mTOR (AZ64).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4771a84b6bf121110556ffa4dcb40491
https://doi.org/10.1158/1535-7163.22508377
https://doi.org/10.1158/1535-7163.22508377
Autor:
Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones
Two dimensional CyQuant cell proliferation assay of (A) MDA-MB-468 and (B) PC3 cells following 3 days of treatment under normoxic and hypoxic conditions with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bde0d00b5065de6ca244068f1993d0
https://doi.org/10.1158/1535-7163.22508374
https://doi.org/10.1158/1535-7163.22508374