Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Barrie Martin"'
Autor:
Bryan Roberts, Nicola J. Webb, Catherine Barber, David J. Liptrot, Robert Dods, Tim Luker, Barrie Martin, Michael J. Stocks
Publikováno v:
Tetrahedron Letters. 52:3793-3796
A new, efficient and practical synthesis of quinazolin-4(3H)-ones is reported via molybdenum-mediated cyclocarbonylation using microwave irradiation. These methods allow access to a wide range of quinazolin-4(3H)-ones in reasonable yields without the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a3c7bd70b3c6cfc328c320f9be01a7
https://doi.org/10.1016/j.tetlet.2011.05.052
https://doi.org/10.1016/j.tetlet.2011.05.052
Autor:
Rukhsana Tasneem Mohammed, Barrie Martin, David Donald, Simon Guile, Anthony Ingall, Andrew Wright, Cooper Martin, Richard J. Lewis, Reynolds Rachel Heulwen, John R. Bantick, Stephen A. St-Gallay, Eyssade Christine, Timothy J. Potter
Publikováno v:
Journal of Medicinal Chemistry. 50:254-263
We have previously described a novel series of potent blockers of the monocarboxylate transporter, MCT1, which show potent immunomodulatory activity in an assay measuring inhibition of PMA/ionomycin-induced human PBMC proliferation. However, the pref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a101fa7262ebe7cd56a2fe4fb2bb4a
https://doi.org/10.1021/jm060995h
https://doi.org/10.1021/jm060995h
Autor:
Cooper Martin, Clare Murray, Iain J. Martin, Reynolds Rachel Heulwen, Eyssade Christine, Anthony Ingall, Douglas Ferguson, Andrew M. Davis, Raymond Hutchinson, Evans Richard, David Donald, Phillip Thorne, Perry Matthew, Barrie Martin, John R. Bantick, Rukhsana Tasneem Mohammed, Stephen J. Hill, Simon Guile, Lee P. Kingston, David Cheshire, Jane Withnall, David J. Wilkinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2260-2265
A novel series of potent blockers of the monocarboxylate transporter, MCT1, is disclosed. From very potent but lipophilic lead compounds, systematic changes to all parts of the molecule, targeting reduction in log D, afforded compounds with significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9008095be3d29fc103a2c186b3f3bb6d
https://doi.org/10.1016/j.bmcl.2006.01.024
https://doi.org/10.1016/j.bmcl.2006.01.024
Autor:
Sara Botterell, Linda Stein, Christopher A. Luckhurst, Nicola J. Webb, Mark Furber, Marianne Ratcliffe, Andrew Walding, Wendy Tomlinson, Gary Allenby, Barrie Martin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Small molecule isoindoline and tetrahydroisoquinoline derivatives have been identified as selective agonists of human peroxisome proliferator-activated receptor δ (PPARδ. Compound 18 demonstrated efficacy in a biomarker for increased fatty acid oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c4e2a50c8c0b2e1477651393d8e9af
https://pubmed.ncbi.nlm.nih.gov/21094606
https://pubmed.ncbi.nlm.nih.gov/21094606
Autor:
Anthony Ingall, Brian Springthorpe, Simon Guile, Chapman David, Paul D. Leeson, Timothy Nicholas Birkinshaw, Garry Pairaudeau, Simon F. Hunt, John Dixon, Michael Mortimore, Richard J. Lewis, Barry Teobald, Dermot F. McGinnity, Brown Roger Charles, Stuart W. Paine, Anil Patel, Robert J. Riley, Francis Ince, Wendy Tomlinson, Kirk Ian, Roger Bonnert, Andrew Bailey, Aaron Rigby, Patrick Barton, Paul Willis, Barrie Martin, P. Leff, R.G. Humphries, Peter J. H. Webborn
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described. Modifications of the acidic side chain and the purine core and investigation of hydrophobic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6951535cd7d2c326d389158dd07fcea
https://pubmed.ncbi.nlm.nih.gov/17827008
https://pubmed.ncbi.nlm.nih.gov/17827008
Publikováno v:
ChemInform. 38
The reaction between N-hydroxyphthalimide and optically pure epichlorohydrin followed by addition of methanol represents a straightforward procedure for the synthesis of isoxazolidin-4-ols in high enantiomeric purity. Under the same conditions, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bb77376575e0b2f6771f63b31e0763
https://doi.org/10.1002/chin.200705124
https://doi.org/10.1002/chin.200705124
Autor:
Barrie, Martin D., Nichols, Gregory
Publikováno v:
Toxicological Risk Assessment for Beginners; 2015, p135-159, 25p