Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Barrie, Wilkinson"'
Autor:
Guy Polturak, Rajesh Chandra Misra, Amr El-Demerdash, Charlotte Owen, Andrew Steed, Hannah P. McDonald, JiaoJiao Wang, Gerhard Saalbach, Carlo Martins, Laetitia Chartrain, Barrie Wilkinson, Paul Nicholson, Anne Osbourn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Isoflavones are a group of phenolic compounds mostly restricted to plants of the legume family, where they mediate important interactions with plant-associated microbes, including in defense from pathogens and in nodulation. Their well-studi
Externí odkaz:
https://doaj.org/article/f1ca8ca270b6413bb8708491762184d4
Autor:
Thomas J. Booth, Kenan A. J. Bozhüyük, Jonathon D. Liston, Sibyl F. D. Batey, Ernest Lacey, Barrie Wilkinson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Reprogramming biosynthetic assembly-lines is a topic of interest for antibiotics. Here, the authors explore the evolutionary biosynthesis of anti-tubercular wollamides, show gene duplication and neo-functionalisation results in bifurcation allowing f
Externí odkaz:
https://doaj.org/article/c6485702e3fd45c2999eb468bf343acc
Autor:
Christine E. Robbins, Bhumil Patel, Danielle L. Sawyer, Barrie Wilkinson, Brian K. Kennedy, Mark A. McCormick
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105410- (2022)
Summary: Deletion of genes encoding ribosomal proteins extends lifespan in yeast. This increases translation of the functionally conserved transcription factor Gcn4, and lifespan extension in these mutants is GCN4-dependent. Gcn4 is also translationa
Externí odkaz:
https://doaj.org/article/4ba365963a08418e9b35c325ae632963
Autor:
Sarah F. Worsley, Tabitha M. Innocent, Neil A. Holmes, Mahmoud M. Al-Bassam, Morten Schiøtt, Barrie Wilkinson, J. Colin Murrell, Jacobus J. Boomsma, Douglas W. Yu, Matthew I. Hutchings
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background The cuticular microbiomes of Acromyrmex leaf-cutting ants pose a conundrum in microbiome biology because they are freely colonisable, and yet the prevalence of the vertically transmitted bacteria Pseudonocardia, which contributes
Externí odkaz:
https://doaj.org/article/157ef7457d104f839136671800f790eb
Autor:
Mohammad Nur-e-Alam, Ifat Parveen, Barrie Wilkinson, Sarfaraz Ahmed, Rahman M. Hafizur, Ahmed Bari, Timothy J. Woodman, Michael D. Threadgill, Adnan J. Al-Rehaily
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Teucrium yemense, a medicinal plant commonly grown in Saudi Arabia and Yemen, is traditionally used to treat infections, kidney diseases, rheumatism, and diabetes. Extraction of the dried aerial parts of the plant with methanol, followed by
Externí odkaz:
https://doaj.org/article/82fc41ffecd743cc935b70e07d5596b3
Autor:
Sarah F. Worsley, Michael C. Macey, Samuel M. M. Prudence, Barrie Wilkinson, J. Colin Murrell, Matthew I. Hutchings
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Streptomyces species are saprophytic soil bacteria that produce a diverse array of specialized metabolites, including half of all known antibiotics. They are also rhizobacteria and plant endophytes that can promote plant growth and protect against di
Externí odkaz:
https://doaj.org/article/eea89b6c2cba4b1cbd9a2dd92a5ec0ba
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the
Externí odkaz:
https://doaj.org/article/8cf9bcdb3d87424c8659c18fd8f71d39
Autor:
Daniel Heine, Neil A. Holmes, Sarah F. Worsley, Ana Carolina A. Santos, Tabitha M. Innocent, Kirstin Scherlach, Elaine H. Patrick, Douglas W. Yu, J. Colin Murrell, Paulo C. Vieria, Jacobus J. Boomsma, Christian Hertweck, Matthew I. Hutchings, Barrie Wilkinson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Acromyrmex ants cultivate fungus gardens that can be parasitized by Escovopsis sp., leading to colony collapse. Here, Heine et al. identify two secondary metabolites produced by Escovopsis that accumulate in Acromyrmex tissue, reduce behavioural defe
Externí odkaz:
https://doaj.org/article/2e969411613d435eba4ecc55f43f0883
Autor:
Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.
Externí odkaz:
https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Obafluorin is a β-lactone antibiotic produced byPseudomonas fluorescens. Here the authors present the biosynthetic gene cluster and biosynthetic pathway of obafluorin, which is characterized by a central transaldolase step catalysed by a rare L-thre
Externí odkaz:
https://doaj.org/article/7b242d2ca4034e769a1c3a08715872de