Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Barrett R. Cooper"'
Autor:
Philip W. Scates, Morton Harfenist, Jane Croft Harrelson, John E. Hughes, Ron M. Norton, Helen L. White, Barrett R. Cooper, Greg C. Rigdon, Thomas E. Johnson, Stacey A. Jones
Publikováno v:
Drug Development Research. 45:1-9
2614W94 [3-(1-trifluoromethyl)ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a Ki value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a25e0b5600923f48269e88d37572b4
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<1::aid-ddr1>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<1::aid-ddr1>3.0.co
Autor:
Ann O. Davis, G. Evan Boswell, Barrett R. Cooper, F. E. Soroko, David Lee Musso, James L. Kelley
Publikováno v:
Journal of Heterocyclic Chemistry. 34:1813-1820
A series of bicyclo analogues of several 2-phenylmorpholines were synthesized and tested for anti-tetrabenazine activity in mice. Most of the target compounds were prepared by reaction of 2-bromopropio-phenone (22) with the appropriate amino alcohol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e46bd9b852e874560d649fbcd635b9
https://doi.org/10.1002/jhet.5570340629
https://doi.org/10.1002/jhet.5570340629
Autor:
James L. Kelley, Barrett R. Cooper, Ed W. McLean, Durcan Mj, James A. Linn, Mark P. Krochmal, Bullock Rm
Publikováno v:
Journal of Medicinal Chemistry. 40:3207-3216
A series of 6-(alkylamino)-9-alkylpurines was synthesized and evaluated for the property of antagonizing the behavioral effects in animals of the dopamine agonist apomorphine. This model for identifying potential antipsychotic agents is based on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea703f9d03508e51e2a08b92a28727c
https://doi.org/10.1021/jm960662s
https://doi.org/10.1021/jm960662s
Autor:
Virginia M. Boncek, James L. Howard, Greg C. Rigdon, Gerald T. Pollard, Barrett R. Cooper, Mark H. Norman, Walter L Faison, Kevin P. Nanry
Publikováno v:
Neuropsychopharmacology. 15:231-242
1192U90 was developed on the assumption that antagonism of 5-HT2 receptors efficacy yields more potently than D2 receptors against positive and negative symptoms of schizophrenia with minimal liability for extrapyramidal side effects (EPSs), and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2b4402d620dd5a9ecb394731b2f749
https://doi.org/10.1016/0893-133x(95)00239-a
https://doi.org/10.1016/0893-133x(95)00239-a
Publikováno v:
Life Sciences. 58:1315-1321
Extracts of Ginkgo biloba leaves produce reversible inhibition of rat brain monoamine (MAO). Both MAO-A and -B types were inhibited to a similar extent. The MAO inhibitory compound(s) were present in dried or fresh Ginkgo biloba leaves as well as in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cd48bf412edbefba0d31baed16efb4
https://doi.org/10.1016/0024-3205(96)00097-5
https://doi.org/10.1016/0024-3205(96)00097-5
Publikováno v:
Journal of Heterocyclic Chemistry. 33:33-39
A series of analogues of 2-phenylmorpholines with alkyl substituents at the C-3 position were synthesized for anti-tetrabenazine (anti-TBZ) testing in mice. The target compounds were prepared by reaction of (2-bromoalkyl) phenyl ketones 21a-h with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7022b12ac437e54955935638cb567577
https://doi.org/10.1002/jhet.5570330106
https://doi.org/10.1002/jhet.5570330106
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1417-1421
The imidazo[4,5-d]-1,2,3-triazine and pyrazolo[3,4-d]-1,2,3-triazine analogues of the potent anticonvul-sant purine, BW 78U79 (9-(2-fluorobenzyl)-6-methylamino-9H-purine, 1), were synthesized and tested for anticonvulsant activity. The imidazo[4,5-d]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6add8bd6229efcb002873fc22829e07
https://doi.org/10.1002/jhet.5570320502
https://doi.org/10.1002/jhet.5570320502
Publikováno v:
Journal of Medicinal Chemistry. 37:2552-2563
A series of novel 4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl) cyclic amides was prepared and evaluated as potential antipsychotic agents. The target compounds were examined in vitro for their binding affinities to the dopamine D2, serotonin 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d4750d965c9a2662d531a0ff71e84a
https://doi.org/10.1021/jm00042a008
https://doi.org/10.1021/jm00042a008
Publikováno v:
Biochemical pharmacology. 23(Suppl 1)
Adult and neonatal rats treated with 6-OHDA to reduce NE, DA or both catecholamines have been used to examine the role of brain catecholamines in several behaviours (Table 1). The data implicated DA-containing fibres in the maintenance of several div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7392498379d689766195f54c910db319
https://pubmed.ncbi.nlm.nih.gov/21394240
https://pubmed.ncbi.nlm.nih.gov/21394240
Autor:
F. E. Soroko, James L. Kelley, Barrett R. Cooper, D. D. Bankston, James A. Linn, Christopher J. Burchall
Publikováno v:
ChemInform. 26
Eleven substituted 8-amino-3-benzyl-1,2,4-triazolo[4,3-a] pyrazines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. The compounds were prepared in four stages from the phenylacetoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f4b73573bb38bcfb3e31f4af899dcf
https://doi.org/10.1002/chin.199552164
https://doi.org/10.1002/chin.199552164